Method for separating and purifying temsirolimus

A technology for separation and purification of temsirolimus, applied in the field of separation and purification of generic drugs, can solve the problems of inflammable and explosive, unsuitable for industrialized large-scale production, low boiling point of diethyl ether, etc. Effect
CN109851626AActive Publication Date: 2019-06-07YANGTZE RIVER PHARM GRP SICHUAN HAIRONG PHARM CO LTD
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
YANGTZE RIVER PHARM GRP SICHUAN HAIRONG PHARM CO LTD
Publication Date
2019-06-07

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Abstract

The invention discloses a method for separating and purifying temsirolimus. The method comprises the following steps: (1) synthesis of a crude product; and (2) separation and purification. The specific separation and purification method has the advantages of great improvement of the purity and the yield of temsirolimus, reduction of the cost, and broad market application prospect.
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Description

technical field

[0001] The invention belongs to the field of separation and purification of generic drugs, in particular to a method for separation and purification of temsirolimus. Background technique

[0002] Temsirolimus (Temsirolimus) (Temsirolimus) (Temsirolimus) (Temsirolimus) (Temsirolimus) is an intravenous injection of mTOR inhibitors, approved for the treatment of advanced renal cell carcinoma, is a derivative and prodrug of sirolimus. Tesirolimus uses rapamycin (sirolimus) as a raw material, through esterification, deprotection and other synthetic processes to generate temsirolimus finished product with low purity and high isomer content. Most of the current research reports are the separation and purification methods of rapamycin (sirolimus) (CN104844620A, CN107619413A, etc.). According to reaxys search, there are few reports on the isolation and purification of temsirolimus. Zheng Congshen et al. announced a refinement study of temsirolimus in the "13th Natio...

Claims

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