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Spectroscopic systems and methods for the identification and quantification of pathogens

A pathogen and spectral technology, applied in the field of spectroscopy systems and methods for the identification and quantification of pathogens, can solve the problem of inability to quantify the pathogenic load of serum and achieve high sensitivity

Inactive Publication Date: 2019-06-07
MONASH UNIV
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  • Claims
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Problems solved by technology

The techniques described above do not quantify the pathogenic load in serum

Method used

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  • Spectroscopic systems and methods for the identification and quantification of pathogens
  • Spectroscopic systems and methods for the identification and quantification of pathogens
  • Spectroscopic systems and methods for the identification and quantification of pathogens

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Embodiment Construction

[0063] Direct detection and identification of pathogens

[0064] In some variations, pathogens in a sample can be detected and identified based on their IR / Raman spectroscopic features representative of their particular molecular phenotype. Pathogens can be separated from biological fluids by filtration and then pre-concentrated on the surface of an ATR crystal or substrate for infrared and / or Raman spectroscopy.

[0065] The method may include the steps of collecting whole blood into a serum separation tube and generating serum by, for example, centrifugation (eg, 100-10000 RCF, 1-20 minutes). The serum is filtered using a filtration system having a selectable pore size between about 0.015 micron to 1 micron pore size which allows the filtration system to retain any pathogens of the serum sample on the filter surface. Filter materials can be selected based on the need for hydrophobic or hydrophilic filtration characteristics. The filter may be washed using, for example, u...

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Abstract

A system for detecting a disease agent in a sample derived from a patient biofluid may comprise a receiver coupled to a communication network and a controller coupled to the receiver. The controller may comprise a processor and a memory. The controller may be configured to generate an infrared spectrum of the sample. The sample spectrum may comprise one or more sample spectral components, the sample spectral components comprising a sample wavenumber and a sample absorbance value. A set of reference spectral models may comprise one or more reference spectral components. The reference spectral components may comprise a reference wavenumber and a reference absorbance value. The reference spectral components may comprise one or more pathogen characteristics associated with sepsis. The one or more sample spectral components may be classified as pathogenic using the reference spectral models. Pathogen data may be generated using the classified sample spectral components.

Description

[0001] Cross References to Related Applications [0002] This application claims priority to Australian Provisional Patent Application No. 2016903287, entitled Spectroscopic Method and Device for Diagnosis of Pathogens causing Sepsis, filed 19 August 2016 rights, the contents of said Australian Provisional Patent Application are hereby incorporated by reference in their entirety. Background technique [0003] sepsis [0004] Sepsis is caused by a patient's immune response triggered by infection with a pathogen. The infection is most often bacterial, but can also be of fungal, viral or parasitic origin. Sepsis can be life-threatening when a patient's response to infection damages his own tissues and organs. Common signs and symptoms include fever, increased heart rate, increased respiratory rate, and confusion. But in the very young, the elderly, and people with weakened immune systems, there may be no specific symptoms of infection and the temperature may be low or normal ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12M1/00C12M1/36C12M1/34C12Q1/04G01N21/35G01N21/65
CPCC12Q1/04G01N21/552G01N21/65G01N21/3577G01N2021/3595G01N21/35G16B5/00G01N2800/26
Inventor 拜登·罗伯特·伍德菲利普·罗伯特·赫奥德大卫·佩雷斯·古埃塔卡米拉·纳塔利娅·科汉
Owner MONASH UNIV
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