50 results about "Disease agent" patented technology

Methods of inducing T cell proliferation and expansion in vivo for treating conditions wherein antigen-specific T cell immune response are therapeutically desirable such as cancer, infection, inflammation, allergy and autoimmunity and for enhancing the efficacy of vaccines are provided. These methods comprise the administration of at least one CD27 agonist, preferably an agonistic CD27 antibody, alone or in association with another moiety such as immune stimulant or immune modulator such as an anti-CD40, OX-40, 4-IBB, or CTLA-4 antibody or an agent that depletes regulatory cells, or a cytokine. These mono and combination therapies may also optionally include the administration of a desired antigen such as a tumor antigen, an allergen, an autoantigen, or an antigen specific to an infectious agent or pathogen against which a T cell response (often CD8+) is desirably elicited.

A method for reducing dental disease in a patient comprises a patient wearing in the patient's mouth an appliance containing an oral care product comprising a carrier and an anti-dental disease agent with a pH above 7.0. The appliance brings the patient's teeth in direct and sustained contact with the product and is custom made for each individual patient. The oral care product is specifically prescribed and formulated for the particular dental disease of that individual patient.

The present invention relates to methods and systems for administering antibody therapeutic agents. The methods include administering one or more (e.g., two or three) binding agents, wherein each of the binding agents has a binding region that is specific to a portion of a disease agent and one or more copies of a tag. The binding agents can be specific to one or more portions of the same or different disease agents. The tag is the same for each of the binding agents. The methods include administering an anti-tag antibody, wherein the anti-tag antibody has an anti-tag region that is specific to the tag, and can have an immunoglobulin (e.g., IgA, IgD, IgE, IgG, and IgM.). Disease agents include bacterial proteins, viral proteins, cancer cells, and proteins or toxins produced therefrom. In particular, the present invention includes methods and systems for binding agents that are specific to neurotoxins that cause botulism.

Agents and methods for imaging a cell and / or a portion of tissue characterized by fibrosis, as well as to agents and methods for determining and / or diagnosing fibrotic diseases are disclosed herein. Also disclosed herein are polymer conjugates that can include a detectable label, a retinoid and a polymer. The polymer conjugates can be used to image a portion of tissue, deliver a detectable label to a portion of tissue or a cell and / or diagnosis a condition or disease.

A system for detecting a disease agent in a sample derived from a patient biofluid may comprise a receiver coupled to a communication network and a controller coupled to the receiver. The controller may comprise a processor and a memory. The controller may be configured to generate an infrared spectrum of the sample. The sample spectrum may comprise one or more sample spectral components, the sample spectral components comprising a sample wavenumber and a sample absorbance value. A set of reference spectral models may comprise one or more reference spectral components. The reference spectral components may comprise a reference wavenumber and a reference absorbance value. The reference spectral components may comprise one or more pathogen characteristics associated with sepsis. The one or more sample spectral components may be classified as pathogenic using the reference spectral models. Pathogen data may be generated using the classified sample spectral components.

The present invention has an object to provide a novel agent for anti-neurodegenerative diseases and solves the object by providing an agent for anti-neurodegenerative diseases containing, as an effective ingredient, the compound(s) represented by the following General formula 1:wherein in General formula 1, R1 through R3 independently represent a hydrogen atom or an appropriate substituent; Z1 represents a heterocyclic ring and Z2 represents the same or different heterocyclic or aromatic ring as in Z1, wherein the heterocyclic and aromatic rings optionally have a substituent; represents an integer of 0, 1 or 2; p represents an integer of 0 or 1, with the proviso that p is 1 when o is 0 or 2, and p is 0 when o is 1; R1 and R2 do not exist when o is 0, while, when p is 0, R3 does not exist and the binding between the carbon atom to which R2 binds and Z2 is a single bond; X1− represents an appropriate counter anion and q represents an integer of 1 or 2.

The invention discloses a method for culturing a special microbial strain for original ecological live pigs, and the method comprises the steps of building a pit or a pond with 60-80cm under or abovethe ground, dividing the height of the pit or the pond into three equal parts, then filling waste plant stems and leaves into the pit or the pond by three times, treading, simultaneously placing the solid microbial strain into the pit or the pond by three times and treading, wherein the using amount of the solid microbial strain is 1kg / square meter; then using 600 times of water for diluting a traditional Chinese medicine anti-disease agent and lactic acid serum and pouring into the pit, wherein the using amount is 0.4kg / square meter; and carrying out fermentation for 5 days and then feeding the pigs. The method can lead the pigs to grow healthily and rapidly, thereby being the novel scientific culture method with no pollution, high efficiency, time-saving, effort-saving and material-saving properties, and situation of hardly using antibiotics. The microbial strain generates biological heat during the fermentation process and can effectively solve the problem of excessively low temperature in winter in Northern China, decompose pig manure and solve environmental protection problem.

Methods, compositions and kits are provided for treating a subject exposed to or at risk for exposure to a disease agent using a pharmaceutical composition including at least one recombinant heteromultimeric neutralizing binding protein including two or multiple binding regions, such that the binding regions are not identical, and each binding region specifically binds a non-overlapping portion of the disease agent, thereby treating the subject for exposure to the disease agent. In a related embodiment, the heteromultimeric neutralizing binding protein includes two or multiple binding regions that neutralize a plurality of disease agents. In certain embodiments, the disease agent includes a bacterium, a bacterial protein, a virus, a viral protein, a cancer cell, and a protein or molecule produced therefrom. In certain embodiments, the disease agent is a plurality of different disease agents.

The invention discloses a nanometer antibacterial agent for preventing and controlling plant fungal diseases. The nanometer antibacterial agent is composed of the suspending liquid formed by nanometercopper oxide and water, wherein the concentration of nanometer copper oxide is 50-200mg / L. The efficient plant antibacterial agent prepared according to the invention has obvious effects of promotingthe pathogen resistance of plants and restraining the fungus infection of plant blades and is capable of effectively preventing and restraining the fungus infection of plant blades.

Techniques for applying torque to microscopic paramagnetic structures in a body includes exposing a body simultaneously to a first magnetic field oscillating at a first frequency in a first direction and a different second magnetic field oscillating at a second frequency in a second direction. The body includes a plurality of microscopic paramagnetic structures for which magnetic susceptibility to the first magnetic field is different from magnetic susceptibility to the second magnetic field. Such techniques are effective for ameliorating a symptom of a disease in an animal in which disease agents or diseased cells selectively include microscopic paramagnetic structures, including malaria.

The present invention provides DNA vaccines comprising an antibiotic resistance gene-free plasmid, methods of generating same, and methods for treating a disease agent, comprising same.

The present invention relates to methods and systems for administering antibody therapeutic agents. The methods include administering one or more (e.g., two or three) binding agents, wherein each of the binding agents has one or more monomers that have a binding region that is specific to a portion of a disease agent and one or more copies of a tag. The binding agents can be specific to one or more portions of the same or different disease agents. The tag is the same for each of the binding agents. The methods include administering an anti-tag antibody, wherein the anti-tag antibody has an anti-tag region that is specific to the tag, and can have an immunoglobulin (e.g., IgA, IgD, IgE, IgG, and IgM.). Disease agents include bacteria, bacterial proteins, viruses, viral proteins, cancer cells, and proteins or toxins produced therefrom or from other sources such as snakes, insects, plants, etc. In particular, the present invention includes methods and systems for binding agents having one or more monomers that are specific to neurotoxins that cause botulism.

A system for detecting a disease agent in a sample derived from a patient biofluid may comprise a receiver coupled to a communication network and a controller coupled to the receiver. The controller may comprise a processor and a memory. The controller may be configured to generate an infrared spectrum of the sample. The sample spectrum may comprise one or more sample spectral components, the sample spectral components comprising a sample wavenumber and a sample absorbance value. A set of reference spectral models may comprise one or more reference spectral components. The reference spectral components may comprise a reference wavenumber and a reference absorbance value. The reference spectral components may comprise one or more pathogen characteristics associated with sepsis. The one or more sample spectral components may be classified as pathogenic using the reference spectral models. Pathogen data may be generated using the classified sample spectral components.

The invention discloses a cultivation method for preventing a grass carp enteritis disease. The cultivation method for preventing the grass carp enteritis disease comprises the following steps that firstly, a cultivation pond is managed, wherein a 70-80 degree angle is formed on the straight bottom face of the cultivation pond and the side face where a water outlet is located, a U-shaped groove with the diameter being 20-30 cm is deep excavated in the joint of the bottom face of the cultivation pond and the side face where the water outlet is located, a double-layer filter screen is arranged on a water inlet, and a herb medicine bag with the weight being 200-300 g is placed in the middle of the double-layer filter screen; secondly, mixed cultivation management is performed, wherein 6000-8000 aquatic plants are grown at the bottom of the cultivation pond, flowing water with the height being 1.8-2.2 m is injected into the pond 42-50 days after growth of the aquatic plants, 10000 to 20000 grass carp fry is bred in the pond, 5-10 kg of a composite anti-disease agent is sprayed in the pond every other 20-25 days, and grass carps are driven for 30-45 min every day with a fish driving device; and thirdly, diseased fish is managed. The cultivation method for the grass carps can enhance the immunity and disease resistance of the grass carps, and therefore the enteritis disease is effectively prevented and treated.

A chemical for the plant to resist against diseases and increase yield is prepared through preparing culture medium from chitosan, glucose, NH4NO3, yeast extract, K2HPO4, KH2PO4, NaCl, MgSO4.7H2O and water, fermentive culture of the bacteria able to generate chitosanase, preparing the fermented liquid containing chitosanase, enzymolizing chitosan to obtain enzymolized product, and proportionally mixing it with composite amino acid solution.

Agents for treating Alzheimer's disease comprising a peptide according to sequence no. 1 which binds to Aβ oligomers and thus results in the healing or alleviation of Alzheimer's disease. In further embodiments peptides are provided which contain a sequence no. 1, but have preceding sequence sections which allow the peptide to be secreted. For the purpose of gene therapy, corresponding DNA sequences and vectors, in particular according to sequences 3 to 6, are provided.

A heating assembly designed for reducing foodborne pathogens in bagged food products comprises a heat insulated treatment chamber, multiple high temperature natural gas fired furnaces, multiple insulated ductworks further comprising multiple sets of intake ducts and multiple sets of exhaust ducts, a cooling system that allows air to be controlled and supplied into the treatment chamber, multiple temperature sensor probes placed in the treatment chamber, the natural gas fired furnaces, and the bagged food products, a digital control system, and a computer program that monitors the temperature of each probe. A specially designed racking system with multiple levels allows multiple dry bags containing the food products to be stacked in a manner that rapidly and uniformly heat the food products.

A recombineered Salmonella typhi Ty21a, compositions and vaccines comprising such a Ty21a, and a method for recombineering comprising inserting a large antigenic region into a bacterial chromosome for the purpose of making multivalent vaccines to protect against one or more disease agents are described herein.

Disclosed are novel primers for use in the molecular detection of food-threat agents and food-borne pathogens. The primers may be used in combination for the rapid, high-throughput screening PCR-based techniques to simultaneously detect multiple food safety biothreat agents. The multiplex-detection methods have improved sensitivity and specificity for the detection of multiple high-impact food-borne pathogens simultaneously. Real-time PCR assaying techniques using such primers include microarrays and multiplex single-tube arrays, the latter optionally simultaneously with TaqMan probes.

The invention provides compositions, methods, and kits for the diagnosis or detection of infection by a pathogen that causes Lyme disease in a subject.

The present invention relates to methods and systems for administering antibody therapeutic agents. The methods include administering one or more (e.g., two or three) binding agents, wherein each of the binding agents has a binding region that is specific to a portion of a disease agent and one or more copies of a tag. The binding agents can be specific to one or more portions of the same or different disease agents. The tag is the same for each of the binding agents. The methods include administering an anti-tag antibody, wherein the anti-tag antibody has an anti-tag region that is specific to the tag, and can have an immunoglobulin (e.g., IgA, IgD, IgE, IgG, and IgM.). Disease agents include bacterial proteins, viral proteins, cancer cells, and proteins or toxins produced therefrom. In particular, the present invention includes methods and systems for binding agents that are specific to neurotoxins that cause botulism.

The invention provides konjak plantation fertilizer with the effect of preventing plant diseases and insect pests. The konjak plantation fertilizer comprises urea, potassium chloride, composite amino acids, potassium dihydrogen phosphate, trace elements, a plant growth promoter, an anti-disease agent and a soil modifier. The konjak plantation fertilizer with the effect of preventing plant diseases and insect pests can provide various nutrients for konjak growth, improve a konjak growth soil environment and accelerate a konjak growth rate. The konjak plantation fertilizer can improve disease and insect pest resistance of plants, improve immunity, reduce konjak morbidity, effectively improve konjak crop quality and improve a yield.

The invention discloses a method for improving the egg laying quality of laying hens, and relates to the technical field of laying hen breeding, wherein the method includes the following steps: adjustment of an environment: controlling the temperature of a henhouse at 15-25 DEG C, controlling the humidity of the henhouse at 60%-75%, illuminating the henhouse for 15-18 h daily, and spraying the interior of the henhouse with a disinfectant daily; laying hen breeding: during breeding of the laying hens, feeding the laying hens for 4 times daily, and changing drinking water for 3 times daily; andenhancement of the disease resistance of the laying hens: starting from 5-15 days before egg laying of the laying hens to the end of the egg laying period, and adding an anti-disease agent to drinkingwater daily, wherein the addition amount of the anti-disease agent is 0.05%-0.1% of the amount of the drinking water. Probiotics and other microorganisms are added to disinfectants, drinking water and feeding feeds; the transformation of proteogen is promoted through the interaction of different microorganisms; protease, amylase, lipase and other digestive enzymes can be produced through microbial metabolism, and act on a body together to improve the egg laying quality of the laying hens.

The invention provides compositions, methods, and kits for the diagnosis or detection of infection by a pathogen that causes Lyme disease in a subject.

The present invention discloses a novel method for diagnosing or differentially diagnosing disease mediators and second disease mediators. The disclosed method uses a novel amplification strategy called TemPCR to allow sensitive and specific amplification of target sequences from any disease agent and / or secondary disease agent whose nucleic acid sequence is known. The TemPCR method uses at least one set of target enrichment primers (present in low concentration) specific to the disease agent or secondary disease agent to be detected and at least one pair of common target amplification primers (present in high concentration). At least one pair of said target enrichment primers includes binding sequences for target amplification primers. Thus, the use of the TemPCR method allows multiplex amplification reactions to be performed without the need for empirical optimization of multiplex amplification parameters. Methods for nucleic acid isolation and target sequence detection for use with the TemPCR method are also disclosed.

Agents and methods for imaging a cell and / or a portion of tissue characterized by fibrosis, as well as to agents and methods for determining and / or diagnosing fibrotic diseases are disclosed herein. Also disclosed herein are polymer conjugates that can include a detectable label, a retinoid and a polymer. The polymer conjugates can be used to image a portion of tissue, deliver a detectable label to a portion of tissue or a cell and / or diagnosis a condition or disease.