Application of tanshinone IIA derivative in preparation of ischemic stroke drugs

A technology for ischemic stroke and tanshinone, applied in the field of medicine, can solve the problems of low bioavailability, insignificant protective effect of cerebral infarction and cerebral edema, poor water solubility of tanshinone IIA, etc., so as to improve water solubility and increase bioavailability. Effect
CN109908154AActive Publication Date: 2019-06-21CHINA PHARM UNIV
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
CHINA PHARM UNIV
Publication Date
2019-06-21

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Abstract

The invention relates to application of tanshinone IIA derivative in the preparation of ischemic stroke drugs and belongs to the field of medicine. The high-molecular tanshinone IIA derivative is synthesized herein; pharmacological experiment studies on animals are carried out; experimental results show that the high-molecular tanshinone IIA derivative can well protect cerebral ischemia-reperfusion injury in MCAO (middle cerebral artery occlusion) animal model of an SD (Sprague Dawley) rat; compared with positive controls, the high-molecular tanshinone IIA derivative can evidently improve neurological behaviors, cerebral infarction area and encephaledema of the rat with focal cerebral ischemia. The high-molecular tanshinone IIA derivative provided by the invention helps provide a new ideafor treating ischemic stroke, and has the potential of being developed into drugs to treat ischemic stroke.
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Description

technical field

[0001] The invention relates to the field of medicine, in particular to the application of a tanshinone IIA derivative in the preparation of ischemic stroke medicine, and the compound has a protective effect on cerebral ischemia-reperfusion injury. Background technique

[0002] In recent years, with the acceleration of the aging population in my country, the incidence of cerebrovascular diseases has been increasing year by year. The vast majority of cerebrovascular diseases are strokes caused by ischemia, which seriously endanger human health. At present, the main clinical treatment principles for ischemic stroke are: timely restore the blood flow and reperfusion of blood vessels, improve the blood circulation of the brain, and increase the supply of blood and oxygen in the ischemic area. The main purpose is to save the ischemic penumbra The surviving neurons in the zone reduce the size of the cerebral infarction. (Appelboom G, Strozyk D, Meyers PM, Higashi...

Claims

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