Method for preparing integration bone cartilage stent based on 3DP and laser cladding compound process

Abstract

The invention provides a method for preparing an integration bone cartilage stent based on a 3DP and laser cladding compound process. The 3DP technology is adopted for preparing a stent cartilage lower bone layer, the laser cladding technology is adopted for preparing a cartilage layer, the 3DP and laser cladding technology is adopted for preparing a stent calcification layer, the requirement forthe biocompatibility of the bone cartilage is met while precise preparation of the integration bone cartilage stent is achieved, the requirement for the connecting strength and mechanical strength among all layers of tissue of the stent is met, and the integration bone cartilage stent which meets the structural gradient and mechanical gradient bionics is prepared.

Description

technical field [0001] The invention belongs to the technical field of medical biomaterial preparation, relates to a three-dimensional osteochondral scaffold and a preparation method thereof, in particular to a method for preparing an osteochondral integrated scaffold based on a composite process of 3DP and laser cladding. Background technique [0002] Articular cartilage defects caused by trauma, sports injuries, various arthritic diseases and other factors are very common in clinical practice. Osteochondral damage is often irreversible, often causing osteoarthritis, and even life-threatening. Osteochondral composite tissue defects in joints have become one of the main causes of physical disability. At present, articular cartilage lesions are mainly treated by implanting substitutes, which mainly include autologous or allogeneic tissues, artificial cartilage, etc. Among them, there are problems such as limited sources of autologous or allogeneic tissues and difficulty in s...

AI Technical Summary

Problems solved by technology

This method has good biocompatibility and is easy to operate, but there is no transition layer between the cartilage tissue and the hard bone tissue prepared by this method, and a structural mutation occurs at the joint surface of the cartilage and hard bone, which makes it difficult to prevent the implanted cells from developing in the osteogenic state. Migrate between cells and chondrogenic scaffolds, affecting the proliferation and differentiation of cells in specific areas in their respective microenvironments