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Effective part of syzygium jambos fruit and preparation method thereof and application of effective part in preparing medicine or food with hypoglycemic effect

A technology of effective parts and fruits, applied to the effective parts of rose apple fruit and its preparation, the application field of medicine or food, can solve the problems of unclear scientific connotation of diabetes, insufficient research work on rose apple fruit, etc., and achieve significant hypoglycemia and the effect of protecting the liver

Active Publication Date: 2019-07-02
JIAYING UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, according to the existing literature, the current research work on apple apple fruit is not deep enough, and most of the modern studies on chemical components and pharmacological activities focus on the three medicinal parts of rose apple branches, leaves and stems, especially for rose apple fruit. Systematic research on the material basis and mechanism of hypoglycemic efficacy has not been reported, and the scientific connotation of its traditional effect of treating diabetes is still unclear

Method used

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  • Effective part of syzygium jambos fruit and preparation method thereof and application of effective part in preparing medicine or food with hypoglycemic effect
  • Effective part of syzygium jambos fruit and preparation method thereof and application of effective part in preparing medicine or food with hypoglycemic effect
  • Effective part of syzygium jambos fruit and preparation method thereof and application of effective part in preparing medicine or food with hypoglycemic effect

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Embodiment 1 Preparation of effective parts of rose apple fruit

[0031] (1) Alcoholic extraction step: take the dried apple apple fruit, heat and reflux extract 2 times with an ethanol solution with a volume fraction of 75%, each time for 1 hour, combine the extracts to concentrate and dry to obtain the apple apple fruit alcohol extract; The dosage ratio of rose apple fruit and ethanol solution is 1g: 12mL;

[0032] (2) Extraction step: Suspend the alcoholic extract of roseberry fruit with water, then extract twice with ethyl acetate, and combine the extracts to concentrate and dry to obtain the extraction part of ethyl acetate; the amount of the alcoholic extract of roseberry fruit and water The ratio is 1g:25mL; the volume ratio of ethyl acetate to water in each extraction process is 1:1;

[0033] (3) ODS column chromatography step: put the ODS chromatography column on the ethyl acetate extraction part (the weight consumption of the ODS filler in the ODS column is 3...

Embodiment 2

[0034] Embodiment 2 Preparation of effective parts of rose apple fruit

[0035] (1) Alcoholic extraction step: take the dried apple apple fruit, heat and reflux extract 3 times with a volume fraction of 95% ethanol solution, each time for 0.5h, and combine the extracts to concentrate and dry to obtain the apple apple fruit alcohol extract; The dosage ratio of rose apple fruit and ethanol solution is 1g: 10mL;

[0036] (2) Extraction step: Suspend the alcoholic extract of roseberry fruit with water, then extract 3 times with ethyl acetate, and combine the extracts to concentrate and dry to obtain the extraction part of ethyl acetate; the amount of alcohol extract of roseberry fruit and water The ratio is 1g:20mL; the volume ratio of ethyl acetate to water in each extraction process is 0.6:1;

[0037] (3) ODS column chromatography step: put the ODS chromatography column on the ethyl acetate extraction part (the weight consumption of the ODS filler in the ODS column is 20 times ...

Embodiment 3

[0038] Embodiment 3 Preparation of effective parts of rose apple fruit

[0039] (1) Alcoholic extraction step: take the dried apple apple fruit, heat and reflux extract 3 times with a volume fraction of 50% ethanol solution, each time for 0.8h, and combine the extracts to concentrate and dry to obtain the apple apple fruit alcohol extract; The dosage ratio of rose apple fruit and ethanol solution is 1g: 15mL;

[0040] (2) Extraction step: Suspend the alcoholic extract of roseberry fruit with water, then extract 3 times with ethyl acetate, and combine the extracts to concentrate and dry to obtain the extraction part of ethyl acetate; the amount of alcohol extract of roseberry fruit and water The ratio is 1g:30mL; the volume ratio of ethyl acetate to water in each extraction process is 0.8:1;

[0041](3) ODS column chromatography step: put the ODS chromatography column on the ethyl acetate extraction part (the weight consumption of the ODS filler in the ODS column is 40 times o...

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Abstract

The invention relates to the technical field of natural medicinal chemistry, and particularly discloses an effective part of a syzygium jambos fruit and a preparation method thereof and an applicationof the effective part in preparing a medicine or a food with hypoglycemic effect. The preparation method of the effective part of the syzygium jambos fruit comprises the following steps: an alcohol extraction step: taking the dried syzygium jambos fruit, and extracting an ethanol extract of the syzygium jambos fruit with an ethanol solution; an extraction step: extracting the ethanol extract of the syzygium jambos fruit with ethyl acetate to obtain an ethyl acetate extraction part; an ODS column chromatography step: extracting the ethyl acetate extract onto the ODS chromatography column, firstly eluting the material with a solvent A and performing removal of impurities; eluting the material with a solvent, and collecting the elution part of the solvent B, and performing concentration anddrying to obtain the effective part of the syzygium jambos fruit.

Description

technical field [0001] The invention relates to the technical field of natural medicine chemistry, in particular to an effective part of rose apple fruit, a preparation method thereof and an application in preparing medicine or food with hypoglycemic effect. Background technique [0002] Diabetes is a metabolic disease characterized by chronic hyperglycemia caused by a variety of etiologies. The metabolic disorder of sugar, fat and protein in diabetic patients can lead to a series of chronic complications such as hypertension, kidney disease and vascular disease. Diabetes has become a A worldwide public health problem that seriously threatens human health. According to the latest 8th edition of Diabetes Atlas released by the International Diabetes Federation (IDF), about 425 million adults around the world suffer from diabetes in 2017. 1 diabetes patient dies, and the number of people who die from diabetes in the world exceeds the sum of the deaths from malaria, tuberculosi...

Claims

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Application Information

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IPC IPC(8): A61K36/61A61P3/10A61P1/16A23L33/105A61K131/00
CPCA23V2002/00A61K36/61A61K2236/33A61K2236/333A61K2236/39A61K2236/55A23L33/105A61P1/16A61P3/10A23V2200/32A23V2200/328A23V2250/21A23V2300/14
Inventor 张声源凌梅娣庄远杯林大都张超潘增烽魏爱红
Owner JIAYING UNIV
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