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Method for verifying suitability of nutrient to personalized patient

A nutrient and patient technology, applied in the field of biomedicine, to achieve the effect of easy implementation, high efficiency and solid theoretical basis

Inactive Publication Date: 2019-07-09
武汉百药联科科技有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, traditional epidemiological studies still cannot avoid the influence of various confounding factors, such as occupational and environmental exposures, diet and supplement use

Method used

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  • Method for verifying suitability of nutrient to personalized patient
  • Method for verifying suitability of nutrient to personalized patient
  • Method for verifying suitability of nutrient to personalized patient

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0052] Using the method of the present invention to carry out vitamin D precision nutrition therapy for gout disease includes the following steps:

[0053] 1. Obtaining summary data of nutrient samples and disease samples through GWAS

[0054] We obtained vitamin D-related GWAS pooled data and only selected those strongly associated with vitamin D (P value-8 ), independent inheritance and no linkage disequilibrium effect (r 2 x , the standard error SE corresponding to the effect value, with β x Effect SNP alleles. The genetic data of gout come from the Global Urate Genetics Consortium (GUGC, http: / / www.gwas.eu / gugc / ), which is the result of meta-analysis of 2115 patients and 67,259 normal people from 14 European studies, corresponding The necessary variables about gout disease include SNP ID, effect size β y , the standard error SE corresponding to the effect value, with β y Effect SNP alleles.

[0055] 2. Using Mendelian randomization method to calculate the causal rela...

Embodiment 2

[0062] Using the method of the present invention to treat osteoporosis and rheumatoid arthritis with mineral magnesium precise nutritional therapy, the specific steps are as follows:

[0063] 1. Obtaining summary data on the nutrient magnesium and osteoporosis and rheumatoid arthritis diseases through GWAS

[0064] From the NHGRI-EBI GWAS and PhenoScanner websites, we obtained the GWAS summary data related to the mineral magnesium, and selected those strongly related to magnesium (P value-8 ), independent inheritance and no linkage disequilibrium effect (r 2 <0.01) SNPs were used as instrumental variables (5 effective SNPs related to magnesium were rs11144134, rs13146355, rs3925584, rs4072037 and rs7965584). Data on the genetics of osteoporosis were obtained from the GEFOS consortium (http: / / www.gefos.org), which covered 508,253 patients with osteoporotic fractures of European ancestry and 53,236 patients of European ancestry in the general population, analyzed Approximately ...

Embodiment 3

[0071] Using the method of the present invention for precise nutrition therapy of mineral copper for Alzheimer's disease, the specific steps are as follows:

[0072] 1. Summary data on the nutrient copper and Alzheimer's disease obtained through GWAS

[0073] From the NHGRI-EBI GWAS and PhenoScanner websites, we obtained the GWAS summary data related to mineral copper, and only selected those strongly related to mineral copper (P value-8 ), independent inheritance and no linkage disequilibrium effect (r 2 <0.01) SNPs were used as instrumental variables (two effective SNPs related to copper were rs1175550 and rs2769264). Genetic data for AD were obtained from the Alzheimer's International Genome Project (IGAP), which consisted of 17,18 patients and 37,154 control individuals of European ancestry from 4 GWAS, including the AD Genetics Consortium (ADGC), cardiac and The Cohort Consortium for the Epidemiology of Aging Genomes (CHARGE), the European Alzheimer's Disease Initiative ...

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Abstract

The invention relates to a method for verifying suitability of a nutrient to a personalized patient, wherein the method belongs to the field of biomedicine. The method comprises the following steps of(1), selecting the nutrition which is related with a disease, and according to a genetics analysis method, acquiring genetics association gathering total data between the nutrition and the disease; (2), calculating a cause-and-effect relation between the nutrition and the disease by means of a Mendelian randomization method; (3), acquiring an SNP which is same with the cause-and-effect relation between the nutrition and the disease and is substantially related with the cause effect as a biological marker, and finding out an allele site which corresponds with the biological marker; and (4), performing gene testing on the personalized patient with the disease, and investigating the gene condition of the patient at the biological marker site, if the mutation of the patient at the biologicalmarker site is the allele site of the step (3), determining a fact that the nutrition is suitable for the patient, and otherwise, determining unsuitability of the nutrition to the patient. The methodof the invention can efficiently determine whether the nutrition is suitable for the personalized patient and is easy to realize.

Description

technical field [0001] The invention relates to a method for verifying whether nutrients are suitable for individualized patients, and belongs to the field of biomedicine. Background technique [0002] Former U.S. President Barack Obama launched the Precision Medicine Initiative in 2015, a bold new initiative to support researchers, patients and providers working together to develop medicines that take people into account. Personalized medicine with unique characteristics (Loos, RJF. (2019). From nutrigenomics to personalizing diets: are we ready for precision medicine? Am J Clin Nutr. 109:1-2.). Nutrigenomics can be considered an extension of precision medicine, which aims to prevent, treat, and manage disease through targeted nutritional therapies formulated from an individual's genetic makeup (Bahcall, O. (2015) Precision medicine. Nature.526 :335.). It includes the study of the bidirectional relationship between genes and diet: 1) how genetic variation affects the body...

Claims

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Application Information

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IPC IPC(8): G16H20/60
CPCG16H20/60
Inventor 张红雨程文文朱强全源黄清
Owner 武汉百药联科科技有限公司
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