Preparation method for homoserine lactone hydrochloride

A technology of homoserine lactone and hydrochloride, which is applied in the chemical industry, can solve the problems of high environmental and on-site operation requirements, non-compliance with green production environmental protection requirements, and high raw material prices, so as to reduce consumption and cost input and yield High, high reaction conversion effect

Active Publication Date: 2019-07-12
ANHUI ANLITAI BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there are three main methods for preparing homoserine lactone hydrochloride: one is the iodomethane-methionine method, which has higher raw material prices, more complicated processes, and more troublesome post-processing. And produce a large amount of inorganic salts; the 2nd, dimethyl sulfate-methionine method, dimethyl sulfate belongs to highly poisonous class, higher to environment and on-the-spot operation requirement; The 3rd, chloroacetate-methionine method, the raw material used in this method is cheap , the product cost is low. But the equipment is complicated, the operation is strict, and because of many side reactions, the product yield is only about 50%, especially in the production, a large amount of water is used, and the waste water output is high, which does not meet the environmental protection requirements of green production

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] Weigh 150.0g of DL-methionine solid and 94.5g of monochloroacetic acid solid, put them into a ball mill at a speed of 1000r / min, grind at normal pressure 25°C for 30min, rinse with ethanol and dry to obtain 135g of white solid powder DL-homoserine Lactone hydrochloride. Detect product by melting point method and calculate product purity and reaction conversion rate: product melting point 216-222.5 ℃ (decomposition) (literature value 220-221 ℃), calculate DL-homoserine lactone hydrochloride content 99.0%, DL-methionine conversion The rate is 98.14%.

Embodiment 2

[0016] Weigh 150.0g of L-methionine solid and 94.5g of monochloroacetic acid solid, put them into a ball mill at a speed of 1000r / min, grind at normal pressure 30°C for 30min, rinse with ethanol and dry to obtain 130g of white solid powder L-homoserine Lactone hydrochloride. The product is detected by the melting point method and the product purity and conversion rate are calculated: the melting point of the product is 219-221°C (literature value 220-221°C), the calculated L-homoserine lactone hydrochloride content is 99.5%, and the L-methionine conversion rate is 94.5% %.

Embodiment 3

[0018] Weigh 150.0g of D-methionine solid and 94.5g of monochloroacetic acid solid, put them into a ball mill at a speed of 1000r / min, grind for 30min at normal pressure 35°C, rinse with ethanol and dry to obtain 132g of white solid powder D-homoserine Lactone hydrochloride. The product is detected by the melting point method and the product purity and reaction conversion rate are calculated: the product melting point is 218-220°C (literature value 220-221°C), the calculated D-homoserine lactone hydrochloride content is 99.3%, and the D-methionine conversion rate is 95.9% %.

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Abstract

The invention belongs to the technical field of chemical technologies, and particularly relates to a preparation method for homoserine lactone hydrochloride. Solid methionine and solid chloroacetic acid are mixed and ground to obtain the product. According to the homoserine lactone hydrochloride by using the method, a solid method is adopted in the reaction, no waste water is discharged, fewer side reactions are generated, and the yield is high. The reaction processes are simple, fewer devices are used, and the investment is low.

Description

technical field [0001] The invention belongs to the technical field of chemical industry, and in particular relates to a preparation method of homoserine lactone hydrochloride. Background technique [0002] As an important intermediate, homoserine lactone hydrochloride is widely used in biomedicine, especially for the synthesis of herbicides. At present, there are three main methods for preparing homoserine lactone hydrochloride: one is the iodomethane-methionine method, which has higher raw material prices, more complicated processes, and more troublesome post-processing. And produce a large amount of inorganic salts; the 2nd, dimethyl sulfate-methionine method, dimethyl sulfate belongs to highly poisonous class, higher to environment and on-the-spot operation requirement; The 3rd, chloroacetate-methionine method, the raw material used in this method is cheap , the product cost is low. But the equipment is complicated, the operation is strict, and because of many side reac...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D307/33
CPCC07D307/33
Inventor 马铭泽马云峰
Owner ANHUI ANLITAI BIOTECH CO LTD
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