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Degradable elastic stent material for tissue repair and preparation method of degradable elastic stent material

A tissue repair and elastic scaffold technology, applied in the field of degradable elastic scaffold materials and their preparation, can solve the problems of inability to apply in time, limited application scope, complicated steps, etc., achieve excellent biocompatibility, improve clinical applicability, The effect of improving biocompatibility

Inactive Publication Date: 2019-07-16
HUAZHONG UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The source of autologous tissue is limited, and it is easy to cause defects in the donor site. Allogeneic tissue transplantation will cause immune rejection, resulting in cell death and loss of function, and will be limited by quality and ethics, and the scope of application is limited.
Synthetic repair materials with good biocompatibility can solve the above problems, but further research is needed on specific properties such as strength and toughness
At the same time, there are certain differences in the regeneration ability of various parts of the human body, and the degradation rate of the material is too fast or too slow, which will cause secondary damage to the repaired part.
The currently reported method of using stromal cells, chondrocytes and other seed cells in vitro to culture and amplify materials in tissue engineering has long amplification time, complicated steps, high cost, and cannot be applied in time, so there are certain limitations.

Method used

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  • Degradable elastic stent material for tissue repair and preparation method of degradable elastic stent material
  • Degradable elastic stent material for tissue repair and preparation method of degradable elastic stent material
  • Degradable elastic stent material for tissue repair and preparation method of degradable elastic stent material

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Mix 23.618g of succinic acid, 11.6848mL of glycerin and 2.2304mL of ethylene glycol (molar ratio: 1:0.8:0.2), stir and react at 150°C for 1.5 hours, continue to react for 6 hours under vacuum at -85kPa, and collect products, poured into molds. The mixture was placed in an environment of 150° C. to continue cross-linking for 96 hours, taken out, demolded, finally washed and freeze-dried to obtain the desired non-porous elastic scaffold. The surface of the material is smooth, transparent, and has certain elasticity and tensile strength. For photos of its samples see figure 1 .

Embodiment 2

[0036] Mix 23.618g of succinic acid, 10.2242mL of glycerol and 3.3456mL of ethylene glycol, stir and react at 170°C for 1 hour, and continue to react for 6 hours at a vacuum of -80kPa. Collect the obtained product and pour it into a mold. The mixture was placed in an environment of 140° C. to continue cross-linking for 120 hours, taken out, demoulded, finally washed and freeze-dried to obtain the desired non-porous elastic scaffold.

Embodiment 3

[0038] Mix 23.618g of succinic acid, 11.6848mL of glycerin and 2.2304mL of ethylene glycol, stir and react at 150°C for 1.5 hours, and continue to react for 6 hours at a vacuum of -85kPa. Collect the obtained product and pour it into a selected mold. Add HA powder accounting for 25% of the mass of the prepolymer into the mold, place it at 80° C. and mix thoroughly for 6-12 hours. The mixture was placed in an environment of 150° C. to continue cross-linking for 96 hours, taken out, demolded, finally washed and freeze-dried to obtain the desired non-porous elastic hydroxyapatite scaffold.

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Abstract

The invention discloses a degradable elastic stent material for tissue repair and a preparation method. According to the method disclosed by the invention, succinic acid, glycerine and ethylene glycolare used as basic raw materials, cross-linking and synthesis are performed, and a degradable multi-hole elastic stent material is obtained. The problems of source limit, time tension, rejection and the like of autologous tissue transplantation and variant tissue transplantation can be solved, the intensity is high, hardness, degradation rate, porosity and the like can also be adjusted and controlled according to specific requirements for material application positions, and the degradable elastic stent material has elasticity, easy moulding properties and biodegradability, has favorable biocompatibility, has potential of repair materials for soft tissue of cartilage, skin, muscle and the like of human bodies, and can be used as a tissue repair material.

Description

[0001] Technical field: [0002] The invention belongs to the field of biological materials and tissue engineering, and in particular relates to a degradable elastic support material for tissue repair and a preparation method thereof. [0003] Background technique: [0004] With the continuous development and progress of medical technology and scientific research, human tissue repair materials have attracted great attention. Tissue repair materials are used to repair and replace diseased or damaged tissues in the body, and restore or partially restore the original tissue shape and function. Good tissue repair materials must not only have good biocompatibility, but also be compatible with the tissue at the repair site. The mechanical properties are similar and have a degradation rate that matches the regeneration rate of the tissue. [0005] Take cartilage as an example. Healthy cartilage acts as a shock absorber for the human body and can promote joint sliding. After long-term...

Claims

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Application Information

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IPC IPC(8): A61L27/60A61L27/50A61L27/56A61L27/12A61L27/18C08G63/20
CPCA61L27/12A61L27/18A61L27/50A61L27/56A61L27/60A61L2430/06A61L2430/30C08G63/20C08L67/02
Inventor 张胜民姜雨晴蔡明乐
Owner HUAZHONG UNIV OF SCI & TECH