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Method for constructing organic-inorganic hybrid functional coating on the surface of degradable absorbing metal base

A technology of metal base layer and inorganic coating, applied in the direction of metal material coating process, etc., can solve the problems of lack of biocompatibility, insufficient corrosion degradation control, etc., achieve good biocompatibility, promote osteoblast adhesion, The effect of promoting the growth of osteoblasts

Active Publication Date: 2020-05-19
SOUTHWEST JIAOTONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] The purpose of the present invention is: the present invention provides a method for constructing organic-inorganic hybrid functional coating on the surface of degradable absorbing metal base, by constructing hybrid coating on the surface of degradable metal substrate, to solve the problems in the existing technology Insufficient control of the corrosion degradation of the substrate and lack of biocompatibility of the coating to achieve the dual purpose of simultaneously taking into account the control of corrosion degradation of the substrate and improving its biocompatibility

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  • Method for constructing organic-inorganic hybrid functional coating on the surface of degradable absorbing metal base
  • Method for constructing organic-inorganic hybrid functional coating on the surface of degradable absorbing metal base
  • Method for constructing organic-inorganic hybrid functional coating on the surface of degradable absorbing metal base

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Embodiment 1

[0041] A preferred embodiment of the present invention provides a method for constructing an organic-inorganic hybrid functional coating on the surface of a degradable absorbing metal base, the steps of which are as follows:

[0042] S1. Grinding and polishing the zinc metal sheet with sandpaper, ultrasonic cleaning with deionized water and absolute ethanol respectively, and then vacuum drying;

[0043] S2. Zn(NO 3 ) 2 solution and Na at a concentration of 0.15mol / L 2 HPO 4 solution, and then mix the two solutions in a ratio of 1.0:1 to prepare an inorganic mixed solution, and adjust the pH value of the inorganic mixed solution to 3.2 with NaOH solution;

[0044] S3. Another alendronic acid solution with a concentration of 0.08mol / L was prepared, and the pH value of the alendronic acid solution was adjusted to 3.2 with NaOH solution;

[0045] S4. The zinc metal sheet treated in step S1 is placed in the inorganic mixed solution of step S2 and soaked for 5 minutes at 40° C. ...

Embodiment 2

[0049] A preferred embodiment of the present invention provides a method for constructing an organic-inorganic hybrid functional coating on the surface of a degradable absorbing metal base, the steps of which are as follows:

[0050] S1. Grinding and polishing the zinc metal sheet with sandpaper, ultrasonic cleaning with deionized water and absolute ethanol respectively, and then vacuum drying;

[0051] S2. Zn(NO 3 ) 2 solution and a concentration of 0.18mol / L Na 2 HPO 4 solution, and then the two solutions were mixed in a ratio of 1.2:1 to prepare an inorganic mixed solution, and the pH value of the inorganic mixed solution was adjusted to 3.8 with NaOH solution;

[0052] S3. Prepare an alendronic acid solution with a concentration of 0.10 mol / L, and adjust the pH value of the alendronic acid solution to 3.8 with NaOH solution;

[0053] S4. The zinc metal sheet treated in step S1 is placed in the inorganic mixed solution of step S2 and soaked for 5 minutes at 42° C. to ob...

Embodiment 3

[0057] A preferred embodiment of the present invention provides a method for constructing an organic-inorganic hybrid functional coating on the surface of a degradable absorbing metal base, the steps of which are as follows:

[0058] S1. Grinding and polishing the zinc metal sheet with sandpaper, ultrasonic cleaning with deionized water and absolute ethanol respectively, and then vacuum drying;

[0059] S2. Zn(NO 3 ) 2 solution and Na at a concentration of 0.20mol / L 2 HPO 4 solution, and then mix the two solutions in a ratio of 1.1:1 to prepare an inorganic mixed solution, and adjust the pH value of the inorganic mixed solution to 3.5 with NaOH solution;

[0060] S3. Another alendronic acid solution with a concentration of 0.13mol / L was prepared, and the pH value of the alendronic acid solution was adjusted to 3.5 with NaOH solution;

[0061] S4. The zinc metal sheet treated in step S1 is placed in the inorganic mixed solution of step S2 and soaked for 4 minutes at 45° C. ...

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Abstract

The invention discloses a method for constructing an organic-inorganic hybrid functional coating on the surface of a degradable absorbing metal base, and belongs to the field of surface modification of biological materials. The present invention constructs a hybrid coating on the surface of a zinc-based degradable metal substrate to solve the problems of insufficient corrosion degradation control and lack of biocompatibility of the coating on the substrate in the existing technology, and simultaneously achieves the degradation regulation of the substrate And the dual purpose of improving its biocompatibility.

Description

technical field [0001] The invention belongs to the field of surface modification of biological materials, and in particular relates to a method for constructing an organic-inorganic hybrid functional coating on the surface of a degradable absorbing metal base. Background technique [0002] Degradable metal materials combine the good mechanical properties of traditional metal materials and the characteristics of being absorbed and metabolized by human tissues, and are expected to become a new generation of "revolutionary" biomedical materials. Due to its own characteristics, zinc-based metals in degradable metals can theoretically have a relatively ideal degradation rate in vivo, so they are gradually attracting the attention of researchers. However, the uneven corrosion of zinc-based metal substrates will lead to excessive local zinc ion concentration and cytotoxicity, which affects the biocompatibility of materials, which is a great challenge for the application of zinc-ba...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C23C22/13C23C22/06
CPCC23C22/06C23C22/13
Inventor 万国江莫小山钱军余张文泰鲜鹏唐帅黄楠
Owner SOUTHWEST JIAOTONG UNIV