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Medical transformation formula, kit, transformation method and application of transformation formula

A formula and preparation technology, applied in the field of medical transformation formula

Inactive Publication Date: 2019-07-26
张洁
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, there is no such formula and method in the market now

Method used

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  • Medical transformation formula, kit, transformation method and application of transformation formula
  • Medical transformation formula, kit, transformation method and application of transformation formula
  • Medical transformation formula, kit, transformation method and application of transformation formula

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1-3

[0062]

[0063] In the final formulation of Example 1, about 50% of the lidocaine was present as insoluble granules. In the final formulation of Example 2, about 82% of the tetracaine was present in undissolved (granules or oil droplets) form. In the final formulation of Example 3, about 88% of the tetracaine was present in undissolved (granules or oil droplets) form.

Embodiment 4

[0071] A 50 ml container (kit) contains 30 g of the conversion formula. The transformation formula is a hydrogel containing 0.5% sodium hydroxide, 10% glycerol, 0.8% carbomer 981, 88.7% water, and a pH of approximately 13.

[0072] 10 milliliters of 2% lidocaine hydrochloride injections (initial formulation) are put into above-mentioned container and obtain a new hydrogel (final formula) after stirring rapidly 5 minutes, pH value is about 7, and local anesthetic is in final formula The mass percentage in is 0.5%.

Embodiment 5

[0077] A 60 ml container (kit) contains 38 g of the conversion formula. The transformation formula is a hydrogel containing 0.4% sodium hydroxide, 10% glycerol, 2% hydroxyethylcellulose, 87.6% water, a viscosity of about 10,000 centipoise, and a pH of about 13.

[0078] 5 milliliters of 2% tetracaine hydrochloride injections (initial formulation) are put into above-mentioned container and obtain a new hydrogel (final formula) after stirring rapidly 5 minutes, pH value is about 9, and local anesthetic is in final formula The mass ratio in is 0.15%. In the final formulation of Example 5, about 67% of the tetracaine was present in undissolved (granules or oil droplets) form.

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Abstract

The invention discloses a medical transformation formula, a kit, a transformation method and an application of the transformation formula. The transformation formula is a solution with the pH not lessthan 10 and includes water and an alkaline substance. The final formula is obtained by mixing the transformation formula with a preparation containing local anesthetics, wherein the dosage of the transformation formula makes the pH value of the final formula be 6.5-13, and the mass percentage of amide local anesthetics or ester local anesthetics in the final formula is 0.5% or more or 0.1% or more respectively. The transformation formula can conveniently transform a conventional preparation containing local anesthetics into a transdermal absorption preparation or a sustained-release preparation. The transdermal absorption preparation can anesthetize intact skin in 120 min and anesthetize the whole face skin in 30 min. The sustained-release preparation is directly applied on the human surface without the barrier function the same as the intact skin, the effective ingredients can be released slowly, and thus the duration time of the drug efficacy is prolonged.

Description

technical field [0001] The invention relates to a medical conversion formula, a kit, a conversion method and the application of the conversion formula. Background technique [0002] The injections, gels or powders commonly used in the prior art cannot effectively transmit the active ingredients therein to the skin if they are directly applied to the intact skin. [0003] For example, if 2% lidocaine hydrochloride or lidocaine carbonate injection or 2% lidocaine hydrochloride gel is fixedly applied on the intact skin, the injection and gel will disappear within 120 minutes or even within 180 minutes. Cannot anesthetize intact skin. For another example, putting pure lidocaine hydrochloride powder on the skin surface cannot anesthetize the intact skin. [0004] This is because the traditional and commonly used injections, gels and powders are not administered through transdermal absorption (injections are directly injected into human tissues, gels are generally used on mucous...

Claims

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Application Information

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IPC IPC(8): A61K9/06A61K47/02A61K47/10A61K47/32A61K47/38A61K31/245A61K31/167A61P23/02
CPCA61K9/06A61K9/0014A61K47/02A61K47/10A61K47/32A61K47/38A61K31/245A61K31/167
Inventor 张洁
Owner 张洁
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