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3D printing microfluidic device and large-flux monodisperse emulsion preparation method based on same

A 3D printing and microfluidic technology, applied in the field of microfluidics, can solve the problems of microfluidic chip preparation of droplets in small quantities, rough structure of microfluidic chips, and difficult industrial production, etc., and achieves excellent monodispersity, Simple structure and easy operation

Active Publication Date: 2019-08-02
绍兴钠钇光电有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The microfluidic chips used today are less able to prepare a large number of droplets, the structure is complex, and it is difficult to realize industrial production. The ladder emulsification structure is relatively simple, but the structure of the microfluidic chip generated by the common method is relatively rough, and the generated droplets are larger. Therefore, the application of 3D printers to the production of microfluidic chips can avoid the above shortcomings, and can make the entire detection integration miniaturized and automated, with high throughput, low consumption of detection reagents, small sample volume requirements, and less pollution. Capable of rapid mass production of microfluidic chips with finer structures

Method used

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  • 3D printing microfluidic device and large-flux monodisperse emulsion preparation method based on same
  • 3D printing microfluidic device and large-flux monodisperse emulsion preparation method based on same
  • 3D printing microfluidic device and large-flux monodisperse emulsion preparation method based on same

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Experimental program
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Effect test

Embodiment 1

[0038] The channels and slits are printed as a whole to form a sheet-like rectangular structure with two rows and 6 channels. The dispersed phase distribution device is a thicker shell structure, and then the two are combined with AB glue. The dispersed phase is injected using a syringe pump. The resulting microfluidic device is shown in Figure (1). The dispersed phase used is water, the total pipe flow rate is 30ml / h, and the continuous phase is dimethyl oil bath silicone oil. Since the viscosity of silicone oil is 50cs. The syringe pump uses the laboratory micro-syringe pump LSP01-1A of LongerPump Company. , Dowcorning 749 was added as a surfactant in the oil phase, its mass concentration was 5wt%, and a monodisperse emulsion with uniform and controllable size could be obtained.

Embodiment 2

[0040]The shape of the device is circular pie, and there is a cylindrical liquid storage tank with a diameter of 24mm and a height of 3mm inside. The device has 12 channels evenly arranged, the central angle between each channel is 30°, and the slit is on the side of the device. The microfluidic device is shown in Figure (2), and the specific structural parameters are shown in Figure (4). The dispersed phase used is water, the total pipe flow rate is 30ml / h, and the continuous phase is dimethyl oil bath silicone oil. Since the viscosity of silicone oil is 50cs. The syringe pump uses the laboratory micro-syringe pump LSP01-1A of LongerPump Company. , added Dowcorning 749 as a surfactant in the oil phase, and its mass concentration was 5wt%. Under the above conditions, experiment with this microfluidic device, the device produces continuous droplets with uniform size, and more than 90% of the droplets have a diameter distribution of 0.8-1.2m and uniform size, as shown in Figu...

Embodiment 3

[0042] The shape of the device is circular pie, and there is a cylindrical liquid storage tank with a diameter of 24mm and a height of 3mm inside. This device has 6 channels evenly arranged, and the central angle between each channel is 60°. The slit is on the side of the device, and the corresponding inclination angle is set in the slit area, that is, the top and bottom walls of the slit An inclination angle of α is opened from the connecting channel to the outside to control the size of the generated droplets. The microfluidic device is shown in Figure (3). The dispersed phase used is water, the total pipe flow rate is 30ml / h, and the continuous phase is dimethyl oil bath silicone oil. Since the viscosity of silicone oil is 50cs. The syringe pump uses the laboratory micro-syringe pump LSP01-1A of LongerPump Company. , added Dowcorning 749 as a surfactant in the oil phase, and its mass concentration was 5wt%. Under the above conditions, the microfluidic device is used for...

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Abstract

The invention provides a 3D printing microfluidic device and a large-flux monodisperse emulsion preparation method based on the same. The microfluidic device is produced by 3D printing, the device iscylindrical, the center is a cylindrical channel, the central channel is connected with multiple radially distributed micro-channels, and outlets of the radial micro-channels are of flat wedge structures. A disperse phase is injected from the cylinder center to enter the central channel and flows into the radially distributed micro-channels from the central channel. When a fluid enters flat narrowareas from the micro-channels, the Laplace pressure is higher under extrusion of flat outlets, and meanwhile, the wedge structures cause inner and outside Laplace pressure difference to extrude droplets into a collecting tank. The sizes of generated droplets can be controlled by changing structural parameters of the channels, and prepared droplets have uniform sizes, so that large-scale preparation of monodisperse emulsion with uniform and controllable sizes is realized. The method has the advantages of production simplicity and low cost and can realize industrial production.

Description

technical field [0001] The invention provides a three-dimensional microfluidic device designed and manufactured based on 3D printing technology, and a large flux of monodisperse emulsion is prepared by a step emulsification method. It belongs to the field of microfluidic technology. Background technique [0002] Microfluidic technology integrates the functions of biochemical laboratories into a chip with a size of a few centimeters, which can effectively realize the miniaturization, automation, integration and portability of various functions such as analysis, detection and reaction. Now it has become a new research field interdisciplinary of biology, chemistry, medicine, electronics, machinery and materials. [0003] The microfluidic chip is an important platform for the realization of microfluidic technology. The main feature of the microfluidic chip is its internal microchannels, and the structural dimensions of the reaction chamber and capture chamber are all on the mic...

Claims

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Application Information

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IPC IPC(8): B01L3/00
CPCB01L3/502707B01L3/502784
Inventor 何赛灵陈东王行政陈飞鸿
Owner 绍兴钠钇光电有限公司
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