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A rare earth-doped hydroxyapatite/titanium oxide composite fluorescent coating material and its preparation method and application

A technology of hydroxyapatite and rare earth doping, which is applied in luminescent materials, chemical instruments and methods, and pharmaceutical formulations, and can solve the problems of large amount of rare earth doping, high cost, and poor compatibility

Active Publication Date: 2022-03-25
SHAANXI UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

The development of fluorescence imaging is restricted by the performance of fluorescent materials. The bioluminescent materials used today have poor compatibility between the matrix and the human body, high excitation energy, low fluorescence intensity and fluorescence efficiency, large amount of rare earth doping, complex preparation process, and high cost. higher question

Method used

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  • A rare earth-doped hydroxyapatite/titanium oxide composite fluorescent coating material and its preparation method and application
  • A rare earth-doped hydroxyapatite/titanium oxide composite fluorescent coating material and its preparation method and application
  • A rare earth-doped hydroxyapatite/titanium oxide composite fluorescent coating material and its preparation method and application

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] (1) At room temperature, 11.81 g of Ca(NO 3 ) 2 ·4H 2 O, 0.13g Sm (NO 3 ) 3 and 0.5g Na 3 C 6 H 5 O 7 ·2H 2 O was mixed and dissolved in 50 mL of deionized water, adjusted to pH=9, and mixed solution A was obtained; 4 ) 2 HPO 4 Dissolve in deionized water to prepare a diammonium hydrogen phosphate solution, slowly drop the diammonium hydrogen phosphate solution into the above mixed solution, continue to stir vigorously for 4 hours, and adjust pH=9 with ammonia water to obtain translucent rare earth doped hydroxyapatite sol;

[0038] (2) The rare earth-doped hydroxyapatite sol obtained in step (1) was evenly coated on the quartz glass sheet, and then placed in a constant temperature drying oven at 60°C for 2 hours, and then calcined at 800°C for 3 hours and then followed by drying. The furnace is cooled to room temperature to obtain rare earth-doped hydroxyapatite fluorescent coating material, denoted as Sm 0.01 HA.

[0039] The composition and structure of...

Embodiment 2

[0041] (1) At room temperature, 11.81 g of Ca(NO 3 )2 ·4H 2 O, 0.13g Sm (NO 3 ) 3 and 0.5g Na 3 C 6 H 5 O 7 ·2H 2 O was mixed and dissolved in 50 mL of deionized water, adjusted to pH=9, to obtain a mixed solution; 3.69 g (NH 4 ) 2 HPO 4 Dissolve in deionized water to prepare a diammonium hydrogen phosphate solution, slowly drop the diammonium hydrogen phosphate solution into the above mixed solution, continue to vigorously stir for 4 hours, and adjust pH=9 with ammonia water to obtain translucent rare earth-doped hydroxyapatite Sol, denoted as sol A;

[0042] (2) At room temperature, 17 mL of butyl titanate (C 16 H 36 O 4 Ti) and 83 mL of absolute ethanol (CH 3 CH 2 OH) mixed evenly, and continued stirring for 2h to obtain a light yellow transparent titanium oxide sol, denoted as sol B;

[0043] (3) According to the volume ratio of sol A:sol B=1:1, measure 30 mL of each of sol A and sol B, then mix, stir for 2 hours and then let stand to obtain a rare earth-do...

Embodiment 3

[0047] (1) At room temperature, 11.81 g of Ca(NO 3 ) 2 ·4H 2 O, 0.39g Sm (NO 3 ) 3 and 0.5g Na 3 C 6 H 5 O 7 ·2H 2 O was mixed and dissolved in 50 mL of deionized water, adjusted to pH=9, to obtain a mixed solution; 3.69 g (NH 4 ) 2 HPO 4 Dissolve in deionized water to prepare a diammonium hydrogen phosphate solution, slowly drop the diammonium hydrogen phosphate solution into the above mixed solution, continue to stir vigorously for 4 hours, and adjust pH=9 with ammonia water to obtain translucent rare earth doped hydroxyapatite Stone sol, denoted as sol A;

[0048] (2) At room temperature, 17 mL of butyl titanate (C 16 H 36 O 4 Ti) and 83 mL of absolute ethanol (CH 3 CH 2 OH) and mix evenly, and continue to stir for 2 h to obtain a light yellow transparent titanium oxide sol, which is denoted as sol B;.

[0049] (3) According to the volume ratio of sol A:sol B=1:1, measure 30 mL of each of sol A and sol B, then mix, stir for 2 hours and then let stand to obt...

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Abstract

The invention discloses a rare earth-doped hydroxyapatite / titanium oxide composite fluorescent coating material, which is prepared by mixing rare earth-doped hydroxyapatite sol and titanium oxide sol, and introduces rare earth samarium element to realize photoluminescent emission. After excitation by 406nm light source, the sample has a fluorescence emission peak at 610nm; with the help of the special energy level structure after the compound of hydroxyapatite and titanium oxide, the energy level transition of doped ions can be changed, thereby enhancing its luminous intensity and adjusting its fluorescence lifetime. The invention also discloses a preparation method of the material, the synthesis process is simple, easy to realize, and suitable for mass production, and the material is applied in biological fluorescence imaging.

Description

technical field [0001] The invention relates to a composite fluorescent coating material, in particular to a rare earth-doped hydroxyapatite / titanium oxide composite fluorescent coating material and a preparation method and application thereof. Background technique [0002] With the development of life sciences, biofluorescence imaging technology has attracted more and more attention due to its advantages of less destructiveness, high sensitivity and good selectivity. However, the development of fluorescence imaging is restricted by the properties of fluorescent materials. The bioluminescent materials used today have poor compatibility with the human body, high excitation energy, low fluorescence intensity and fluorescence efficiency, large amount of rare earth doping, complicated preparation process, and high cost. higher issues. Therefore, it is urgent to develop a new fluorescent material. SUMMARY OF THE INVENTION [0003] One of the objectives of the present inventio...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C09K11/81A61K49/00
CPCC09K11/776A61K49/0019
Inventor 乔荫颇陈璞殷海荣白建光
Owner SHAANXI UNIV OF SCI & TECH
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