Wind-dispelling stagnation-eliminating traditional Chinese medicine composition and application thereof

A composition and technology of traditional Chinese medicine, applied in the field of medicine, can solve the problems of bone erosion with no definite curative effect, difficulty in achieving the effect, erosion, etc., and achieve the effect of improving bone erosion, relieving joint swelling and inflammation, and slowing down bone erosion

Active Publication Date: 2019-08-16
JIANGSU PROVINCE INST OF TRADITIONAL CHINESE MEDICINE
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Problems solved by technology

In the inflammatory state of RA, the release of various inflammatory factors such as TNF-a, IL-6, and IL-17 increases, which promotes the differentiation of osteoclasts, enhances the activity of osteoclasts, and limits the activity of osteoblasts, resulting in Bone metabolism disorder, leading to bone erosion (1.Abdel Meguid MH, etal.Relation of interleukin-6 in rheumatoid arthritis patients to systemic bone loss and structural bone damage.Rheumatol Int.2013Mar;33(3):697-703.2.Luo G, et al. TNF-a and RANKL promote osteoclastogenesis by upregulating RANK via the NF kappaB pathway. Molecular medicine reports 2018; 17:6605-6611.3. Ganesan R, et al. Interleukin 17 regulates SHP-2 and IL-17RA/STAT-3 dependent Cyr61 ,IL-23 and GM-CSF expression and RANKL mediatedosteoclastogenesis by fibroblast-like synoviocytes in rheumatoidarthri

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  • Wind-dispelling stagnation-eliminating traditional Chinese medicine composition and application thereof
  • Wind-dispelling stagnation-eliminating traditional Chinese medicine composition and application thereof
  • Wind-dispelling stagnation-eliminating traditional Chinese medicine composition and application thereof

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Embodiment Construction

[0024] The present application will be described in detail below in conjunction with specific embodiments.

[0025] Drug sources: methotrexate, scorpion and centipede decoction pieces are all from the pharmacy of Jiangsu Provincial Hospital of Integrated Traditional Chinese and Western Medicine.

[0026] Preparation of Soufeng Sanjie Recipe: Take whole scorpion decoction pieces, pulverize them into coarse powder, dry at 50-60°C, then pulverize, pass through an 80-mesh sieve, and take 1.5g for later use; take centipede decoction pieces, remove head and feet, pulverize, pass through 80 mesh sieve, take 1.5g for later use; take the above-mentioned scorpion and centipede crushed through 80 mesh, the weight ratio is 1:1, and mix well. 20 grams of astragalus and 30 grams of black bean coat are decocted and then added with scorpion and centipede powder, mixed evenly, and prepared into a drug for animal experiments of corresponding concentration. Modeling of mouse RA model

[0027] ...

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Abstract

The invention discloses a wind-dispelling stagnation-eliminating traditional Chinese medicine composition which is formed by compatibility of whole scorpion, centipede, radix astragali and black beancoat. The invention also discloses an application of the composition in preparation of drugs for treating rheumatoid arthritis bone erosion and rheumatoid arthritis. The wind-dispelling stagnation-eliminating traditional Chinese medicine composition is found out to inhibit the expression of IL-6 and RANKL in various cells of CIA mice joint parts, increase the expression of osteoprotegerin OPG, reduce the number of osteoclasts, increase bone density, alleviate bone erosion in CIA mice, and effectively alleviate CIA mice joint bone swelling and reduce injury of synovium of joint, and has pharmaceutical application prospect for related diseases.

Description

technical field [0001] The invention belongs to the technical field of medicine, in particular to a Soufeng Sanjie traditional Chinese medicine composition and its pharmaceutical application. Background technique [0002] Rheumatoid arthritis (RA) is known as "undead cancer" (Luo Anming et al. On the category of cancer belonging to "blocking phlegm" in traditional Chinese medicine. Chinese Journal of Basic Medicine of Traditional Chinese Medicine 2015,21(01):14-15 ), is a systemic autoimmune disease with erosive polyarthritis as the main manifestation. RA manifests as symmetrical arthritis in the early stage, and joint stiffness and deformity in the late stage. It is a common disease with high disability rate and great harm. difficult disease. It occurs in 0.5-1% of adults worldwide, and the incidence rate is higher in women than in men (Chung IM, et al. Rheumatoid Arthritis: The Stride from Research to Clinical Practice. International journal of molecular sciences, 2016; 1...

Claims

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Application Information

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IPC IPC(8): A61K36/481A61P19/02A61P29/00A61K35/646A61K35/648
CPCA61K35/646A61K35/648A61K36/48A61K36/481A61P19/02A61P29/00A61K2300/00
Inventor 曹鹏胡春萍杨杰蔡雪婷凌媛媛华迪
Owner JIANGSU PROVINCE INST OF TRADITIONAL CHINESE MEDICINE
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