Argon-containing compound, preparation method and uses thereof

A technology for compounds and drugs, applied in the field of medicine, to achieve the effects of small molecular weight, good druggability, and easy quality control

Active Publication Date: 2019-08-16
杨建中
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The present invention provides the preparation method and application of the natural inorganic sulfur-argon compound extracted from the subclass Crustacea of ​​Arthropoda, and there is no related report about the compound in the prior art

Method used

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  • Argon-containing compound, preparation method and uses thereof
  • Argon-containing compound, preparation method and uses thereof
  • Argon-containing compound, preparation method and uses thereof

Examples

Experimental program
Comparison scheme
Effect test

preparation Embodiment 1

[0040] Raw materials: wet insects, after drying and crushing, take 12 kg of fine powder, add it to the extraction tank, add 8-10 times the amount of dilute sulfuric acid prepared with pure water to make the pH value to 1-3, stir and heat to 50-60 °C , After 1 hour, centrifuge for centrifugal filtration, then carry out paper membrane or microporous membrane suction filtration, the suction filtrate is poured into the extraction tank and stirred slowly, adding sodium hydroxide aqueous solution to make the pH value to 8-10; after filtration, wash with pure water until the pH is neutral; stir the filtered solid with 2 times the amount of ethanol and disperse it in a liquid separator at room temperature for 2 hours, then filter it, then wash it with 4 times the amount of pure water, put the solid in a drying oven at 70-80°C for vacuum drying, crush Get raw materials. After testing, its main component is H4 ArO 6 S.

preparation Embodiment 2

[0042] Raw materials: crab shell, after drying and crushing, take 12 kg of fine powder, add it to the extraction tank, add 8-10 times the amount of dilute sulfuric acid prepared with pure water to make the pH value to 1-3, stir and heat to 50-60 ℃, after 1 hour, centrifuge for centrifugal filtration, and then carry out paper membrane or microporous membrane suction filtration, the suction filtrate is poured into the extraction tank and stirred slowly, adding sodium hydroxide aqueous solution to make the pH value to 8-10; after filtration, pump with pure water Wash until the pH value is neutral; stir and disperse the filtered solid matter in a liquid separator at room temperature for 2 hours with 2 times the amount of ethanol, then filter it, then wash it with 4 times the amount of pure water, and vacuum dry the solid matter in a drying oven at 70-80°C. Crushed to obtain raw materials. After testing, its main component is H 4 ArO 6 S.

preparation Embodiment 3

[0044] Raw materials: whole body of hairy shrimp, after drying and crushing, take 12 kg of fine powder, add it to the extraction tank, add 8-10 times the amount of dilute hydrochloric acid prepared with pure water to make the pH value to 1-3, stir and heat to 50-60 ℃, after 1 hour, centrifuge for centrifugal filtration, and then carry out paper membrane or microporous membrane suction filtration, the suction filtrate is poured into the extraction tank and stirred slowly, adding sodium hydroxide aqueous solution to make the pH value to 8-10; after filtration, pump with pure water Wash until the pH is neutral; stir and disperse the filtered solids in a separator at room temperature for 2 hours with 2 times the amount of ethanol, then filter them, then wash them with 4 times the amount of pure water, put the solids in a drying oven for vacuum drying at 70-80°C, and pulverize That is the raw material. After testing, its main component is ArS.

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Abstract

The invention belongs to the technical field of medicine, and relates to an argon-containing compound, a preparation method and uses thereof, wherein the argon-containing compound is ArS or H4ArO6S. The preparation method comprises: extracting Arthropoda Crustacea Malacostraca animal with an acid to obtain an acid extraction liquid, adding an alkali liquid to the acid extraction liquid, carrying out alkali precipitation to obtain a settling product, and purifying the settling product. According to the present invention, the test results prove that the argon-containing compound has remarkable anti-inflammatory and / or analgesic effects, has low side effects, cannot cause addiction property, and is expected to be a drug for preventing and / or treating inflammations or acute and chronic painfuldiseases.

Description

technical field [0001] The invention belongs to the technical field of medicine, and relates to an argon-containing compound and its preparation method and application; specifically, it relates to an argon-containing compound extracted from animals, its preparation method and application. Background technique [0002] Natural products are substances that are produced by metabolism or are biologically active in the process of survival and evolution of living organisms in nature, and are one of the main sources of drug leads. [0003] At the 2004 International Pain Research (IASP) Congress, participating experts reached a consensus: chronic pain is a disease. Pain was recognized as the "fifth vital sign of human beings" after breathing, pulse, body temperature and blood pressure. As for the etiology of chronic pain, research has basically revealed that it is closely related to inflammation, and there are more than 100 kinds of common diseases that can cause pain in varying de...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C01B23/00A61K33/04A61P29/00
CPCA61K33/04C01B23/0005C01P2002/72C01P2002/77A61P29/00C01B23/00
Inventor 杨建中
Owner 杨建中
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