Composite stent and preparation method thereof

Abstract

The invention discloses a composite stent and a preparation method thereof. The composite stent consists of a silk fibroin three-dimensional micropore stent and hydroxylapatite, wherein the hydroxylapatite is uniformly deposited on the surface of the silk fibroin stent. The preparation method of the composite stent comprises the following steps of (1) preparing the silk fibroin three-dimensional micropore stent; and (2) preparing a fibroin / hydroxylapatite composite stent by a microwave-assisted alternate mineralization method. According to the preparation method disclosed by the invention, a microwave-assisted technique is adopted, so that the mineralization time is shortened, the mineralization efficiency is improved, and a composite stent material excellent in properties is prepared; through the adoption of the preparation method disclosed by the invention, the dosage of mineralizing solutions is also reduced, and the preparation cost is reduced; besides, through the adoption of thepreparation method disclosed by the invention, harmful organic solvents are not used, so that environment pollution is prevented from appearing; and moreover, the preparation method is simple to operate, and large-scale industrial production is facilitated.

Description

technical field [0001] The invention relates to the field of biological material preparation, in particular to a composite scaffold and a preparation method thereof. Background technique [0002] Bone is an important organ of the human body. Bone defects caused by trauma, disease or congenital osteogenesis imperfecta seriously affect human health. So far, more than 4 million bone defect operations each year require bone grafting or bone substitutes for repair. However, the source of bone grafting is limited, and it is prone to postoperative infection and various complications, seriously affecting the quality of life of patients. With the continuous development of the field of biomedical materials, various metals, metal alloys, and ceramic stents are widely used in actual treatment, but these materials have general biocompatibility and insufficient mechanical properties, and cannot be implanted into the human body. Satisfactory treatment effect. Therefore, in recent years, ...

AI Technical Summary

Problems solved by technology

The reaction process of preparing composite scaffold materials by direct mixing is complicated and difficult to mix evenly, which seriously affects the forming quality of composite scaffolds; while traditional biomimetic mineralization mainly undergoes mineralization reactions through repeated long-term soaking processes, although composite scaffolds with excellent performance can be prepared. Scaffold material, but its reaction cycle is long, the synthesis efficiency is low, it cannot be used for large-scale preparation and production, and it cannot meet the needs of the market

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