New galangin compound and its preparation method and application

A compound and extract technology, applied in the field of drug preparation, can solve the problems of undisclosed anti-cancer active ingredients and extract research, and achieve the effect of not demanding preparation conditions, significant effect, and high purity

Active Publication Date: 2021-07-13
董玉
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Although the Chinese patent document CN104398950B discloses a calamus four-flavored anti-cancer extract and its preparation method and application, no in-depth research has been carried out on the extract, especially the active ingredients with anti-cancer effects in the extract have not been disclosed

Method used

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  • New galangin compound and its preparation method and application
  • New galangin compound and its preparation method and application
  • New galangin compound and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0048] This example provides a (3,5,7-trihydroxy-2-phenyl-8-[1'S-(2",4",5"-trimethoxy-phenyl)-propyl]-color The preparation method of the original -4-ketone) compound, specifically comprising:

[0049] Shudage-4 includes galangal, asteria, woody and calamus with masses of 8kg, 4kg, 2kg, and 2kg respectively;

[0050] Grind 20kg of the above-mentioned Mongolian medicine compound Shudage-4 medicinal material into coarse powder, 10BV of 50% ethanol, reflux extraction twice, each time for 2h, filter with gauze and combine the filtrate, concentrate until it has no alcohol smell, and dilute to 20L with water get liquid medicine;

[0051] Put the above 20L medicinal solution on the AB-8 macroporous adsorption resin column. After all the sample solution flows out, wash 2BV with water and discard the eluent; 10BV of 50% ethanol is eluted to remove impurities; Elute with 95% ethanol, concentrate the solvent, and dry into a paste to obtain the flavonoid extract of Shudage-4, which is t...

Embodiment 2

[0085]This example provides a (3,5,7-trihydroxy-2-phenyl-8-[1'S-(2",4",5"-trimethoxy-phenyl)-propyl]-color The preparation method of the original -4-ketone) compound, specifically comprising:

[0086] Shudage-4 includes galangal, asteria, woody and calamus with masses of 4kg, 2kg, 1kg, and 1kg respectively;

[0087] Grind 10kg of the Mongolian medicine compound Shudage-4 medicinal material into a coarse powder, reflux extract 12BV of 70% ethanol twice, each time for 2h, filter with gauze, combine the filtrate, concentrate until it has no alcohol smell, and dilute to 12L with water to obtain liquid medicine;

[0088] Put the above-mentioned medicinal solution on a D101 macroporous adsorption resin column, and after the above-mentioned medicinal solution flows out completely, wash 2BV with water, discard the eluent; then use 10BV of 50% ethanol to elute for impurity removal, and then use 8BV of 95 % ethanol was eluted, the solvent was concentrated, and dried into a paste to ob...

Embodiment 3

[0092] This example provides a (3,5,7-trihydroxy-2-phenyl-8-[1'S-(2",4",5"-trimethoxy-phenyl)-propyl]-color The preparation method of the original -4-ketone) compound, specifically comprising:

[0093] Shudage-4 includes galangal, asteria, woody and calamus with masses of 4kg, 2kg, 1kg, and 1kg respectively;

[0094] Grind 10 kg of the above-mentioned Mongolian medicine compound Shudage-4 medicinal material into coarse powder, reflux extract 2 times with 95% ethanol of 12BV, each time for 2 hours, filter with gauze and combine the filtrate, concentrate until it has no alcohol smell, and dilute it with water to 12L to obtain liquid medicine;

[0095] Put the above-mentioned medicinal solution on a D101 macroporous adsorption resin column, and after the above-mentioned medicinal solution flows out completely, wash 2BV with water, discard the eluent; then use 10BV of 50% ethanol to elute for impurity removal, and then use 8BV of 95 % ethanol was eluted, the solvent was concentr...

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Abstract

The invention belongs to the technical field of medicine preparation, and specifically relates to a (3,5,7-trihydroxy-2-phenyl-8-[1'S-(2", 4", 5"-trimethoxy-phenyl)- Propyl]-chromogen-4-ketone) compound and its preparation method and application. (3,5,7-trihydroxy-2-phenyl-8-[1'S-(2",4",5"-trimethyl Oxygen-phenyl)-propyl]-chromogen-4-ketone) compound is yellow needle crystal, easily soluble in solvents such as methanol and chloroform, not easily soluble in water, showing yellow fluorescence under ultraviolet light, and showing yellow fluorescence in iodine Appears yellowish-brown under steam. In addition, the compound has good anticancer activity and can be used in anticancer therapeutic drugs.

Description

technical field [0001] The invention belongs to the technical field of medicine preparation, and specifically relates to a (3,5,7-trihydroxy-2-phenyl-8-[1'S-(2",4",5"-trimethoxy-phenyl)- Propyl]-chromogen-4-one) compound and its preparation method and application. Background technique [0002] Calamus Four Flavors (Shudage-4) is composed of galangal, purple sand, woody, and stone calamus four traditional Chinese medicines, which are commonly used in Mongolian medicine. Traditional Mongolian medicine theory believes that the four flavors of calamus have the functions of relieving asthma and relieving pain, and suppressing "Badaganheyi". For the treatment of diaphragm spasm, chest tightness, shortness of breath, sternocostal tingling, indigestion. [0003] Among the four flavors of calamus, galangal is the dry rhizome of Zingiberaceae. Its main chemical components include flavonoids, diphenylheptanes, volatile oils, glycosides and phenylpropanoids. Stomach meridian, has the...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07D311/30C07D311/40A61P35/00C09K11/06A61K31/352
CPCA61P35/00C07B2200/13C07D311/30C07D311/40C09K11/06C09K2211/1007C09K2211/1088
Inventor 董玉信莎莎王玥璇贾鑫杜银飞朱小玲
Owner 董玉
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