New galangin compound and its preparation method and application
A compound and extract technology, applied in the field of drug preparation, can solve the problems of undisclosed anti-cancer active ingredients and extract research, and achieve the effect of not demanding preparation conditions, significant effect, and high purity
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Embodiment 1
[0048] This example provides a (3,5,7-trihydroxy-2-phenyl-8-[1'S-(2",4",5"-trimethoxy-phenyl)-propyl]-color The preparation method of the original -4-ketone) compound, specifically comprising:
[0049] Shudage-4 includes galangal, asteria, woody and calamus with masses of 8kg, 4kg, 2kg, and 2kg respectively;
[0050] Grind 20kg of the above-mentioned Mongolian medicine compound Shudage-4 medicinal material into coarse powder, 10BV of 50% ethanol, reflux extraction twice, each time for 2h, filter with gauze and combine the filtrate, concentrate until it has no alcohol smell, and dilute to 20L with water get liquid medicine;
[0051] Put the above 20L medicinal solution on the AB-8 macroporous adsorption resin column. After all the sample solution flows out, wash 2BV with water and discard the eluent; 10BV of 50% ethanol is eluted to remove impurities; Elute with 95% ethanol, concentrate the solvent, and dry into a paste to obtain the flavonoid extract of Shudage-4, which is t...
Embodiment 2
[0085]This example provides a (3,5,7-trihydroxy-2-phenyl-8-[1'S-(2",4",5"-trimethoxy-phenyl)-propyl]-color The preparation method of the original -4-ketone) compound, specifically comprising:
[0086] Shudage-4 includes galangal, asteria, woody and calamus with masses of 4kg, 2kg, 1kg, and 1kg respectively;
[0087] Grind 10kg of the Mongolian medicine compound Shudage-4 medicinal material into a coarse powder, reflux extract 12BV of 70% ethanol twice, each time for 2h, filter with gauze, combine the filtrate, concentrate until it has no alcohol smell, and dilute to 12L with water to obtain liquid medicine;
[0088] Put the above-mentioned medicinal solution on a D101 macroporous adsorption resin column, and after the above-mentioned medicinal solution flows out completely, wash 2BV with water, discard the eluent; then use 10BV of 50% ethanol to elute for impurity removal, and then use 8BV of 95 % ethanol was eluted, the solvent was concentrated, and dried into a paste to ob...
Embodiment 3
[0092] This example provides a (3,5,7-trihydroxy-2-phenyl-8-[1'S-(2",4",5"-trimethoxy-phenyl)-propyl]-color The preparation method of the original -4-ketone) compound, specifically comprising:
[0093] Shudage-4 includes galangal, asteria, woody and calamus with masses of 4kg, 2kg, 1kg, and 1kg respectively;
[0094] Grind 10 kg of the above-mentioned Mongolian medicine compound Shudage-4 medicinal material into coarse powder, reflux extract 2 times with 95% ethanol of 12BV, each time for 2 hours, filter with gauze and combine the filtrate, concentrate until it has no alcohol smell, and dilute it with water to 12L to obtain liquid medicine;
[0095] Put the above-mentioned medicinal solution on a D101 macroporous adsorption resin column, and after the above-mentioned medicinal solution flows out completely, wash 2BV with water, discard the eluent; then use 10BV of 50% ethanol to elute for impurity removal, and then use 8BV of 95 % ethanol was eluted, the solvent was concentr...
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