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Thin-payer identification method for effective components of panax notoginseng in musk blood circulation promoting and blood stasis removing paste

A technology for promoting blood circulation and removing blood stasis and thin-layer identification, which is applied in the field of active ingredients of medicines and can solve problems such as inability to obtain

Inactive Publication Date: 2019-08-30
GUIZHOU LIANSHENG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The present invention is aimed at the Chinese and Western medicine plaster combined with traditional Chinese medicine and Western medicine. The sample coating is carried out at high temperature, and all effective substances are in the colloid. It is difficult to pass the existing thin-layer identification and determination method when analyzing the active ingredients of the medicine. Extracting the active ingredients of Panax notoginseng from it alone leads to the problem that more accurate results cannot be obtained. A thin-layer identification method for the active ingredients of Panax notoginseng in Musk Huoxue Huayu Ointment is provided

Method used

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  • Thin-payer identification method for effective components of panax notoginseng in musk blood circulation promoting and blood stasis removing paste
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Effect test

Embodiment 1

[0034] The thin-layer identification method of the active ingredient of Panax notoginseng in the Musk Huoxue Huayu Ointment comprises the preparation of a control group reagent, the preparation of a test group reagent and the TLC identification test, and the preparation of the control group reagent includes the following steps:

[0035] S1, taking notoginseng as a reference medicinal material, adding an extraction reagent, and impregnating to prepare an impregnating solution;

[0036] S2, take the impregnation solution prepared in S1, filter, and the filtrate is the reagent of the control group;

[0037] The reagent preparation of assay group comprises the following steps:

[0038] S1, take musk promoting blood circulation and removing blood stasis ointment, add dissolving reagent, wash off the ointment, and prepare dissolving reagent;

[0039] S2, taking the dissolving reagent prepared in S1, and slowly adding the precipitation reagent until the precipitation is separated ou...

Embodiment 2

[0049] The thin-layer identification method of the active ingredient of Panax notoginseng in the Musk Huoxue Huayu Ointment comprises the preparation of a control group reagent, the preparation of a test group reagent and the TLC identification test, and the preparation of the control group reagent includes the following steps:

[0050] S1, take 0.25 g of the reference medicinal material of notoginseng, add 5 mL of ethanol, and soak for 24 hours to prepare the soaking solution;

[0051] S2, take the impregnation solution prepared in S1, filter, and the filtrate is the reagent of the control group;

[0052] The reagent preparation of assay group comprises the following steps:

[0053] S1, take 4 tablets of Shexiang Huoxuehuayu ointment, add 20mL of chloroform, wash off the ointment, and prepare the dissolving reagent;

[0054] S2, taking the dissolving reagent prepared in S1, and slowly adding ethanol until precipitation occurs to obtain a mixed reagent;

[0055] S3, taking t...

Embodiment 3

[0064] In order to ensure the effect of the present invention, the applicant has carried out corresponding experimental research and demonstration on the identification method of the active ingredient of Panax notoginseng and diphenhydramine hydrochloride in the preparation, as follows:

[0065] TLC Identification and Determination Method for Active Components of Panax notoginseng

[0066] (1) Reagents and reagents

[0067] Musk activating blood circulation and removing blood stasis ointment was provided by Guizhou Liansheng Pharmaceutical Co., Ltd.; the control medicinal materials of Panax notoginseng active ingredients were provided by China Institute for the Control of Pharmaceutical and Biological Products; silica gel G thin-layer board: silica gel G thin-layer board produced by Qingdao Ocean Chemical Factory Branch, Reagents: Chloroform, ethanol, n-butanol and ethyl acetate are of analytical grade.

[0068] (2) Specificity

[0069] Take Musk Huoxue Huayu Ointment, and p...

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Abstract

The present invention relates to the technical field of medicinal effective ingredients, in particular to a thin layer identification method for effective ingredients of Panax notoginseng in musk blood circulation promoting and blood stasis removing paste. The method comprises: a thin layer identification method for atropine sulfate and a thin layer identification method for diphenhydramine hydrochloride. Through characteristics of each pharmaceutical ingredient in the musk blood circulation promoting and blood stasis removing paste, and based on thin layer identification characteristics of the effective ingredients of the Panax notoginseng, the method provides a suitable extraction preparation process and required preparations, thereby being able to separate and extract the ingredients tobe measured from the effective pharmaceutical ingredients of the musk blood circulation promoting and blood stasis removing paste to complete the thin layer identification measurement; and the methodsolves the problem that the musk blood circulation promoting and blood stasis removing paste is emplastrum in combination of Chinese and western medication, that sample coating is carried out at a high temperature, that all effective substances are in colloid, and that more accurate results can not be obtained caused by difficulties to separately extract the effective ingredients from the Panax notoginseng through the existing thin layer identification method in analysis of the effective pharmaceutical ingredients.

Description

technical field [0001] The invention relates to the technical field of active ingredients of medicines, in particular to a method for thin-layer identification of the active ingredients of Panax notoginseng in Musk Huoxue Huayu ointment. Background technique [0002] Musk Huoxue Huayu Ointment is a common Chinese patent medicine, which contains musk, Panax notoginseng, safflower, salvia, boric acid, camphor, dried blood, urea, belladonna liquid extract, diphenhydramine hydrochloride, procaine hydrochloride composition. It has the effects of promoting blood circulation and removing blood stasis, reducing inflammation and relieving pain. For joint sprains, soft tissue contusions, acute lumbar sprains, lumbar muscle strain, frozen shoulder, frostbite without ulceration, and nodular erythema. [0003] Since Musk Huoxuehuayu Plaster is a combination plaster of traditional Chinese medicine and western medicine, the sample coating is carried out at high temperature, and all the a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N30/90
CPCG01N30/90
Inventor 周英徐会罗玉江
Owner GUIZHOU LIANSHENG PHARMA
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