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A photothermal nanomaterial capable of responding to temperature and its preparation method

A nanomaterial, photothermal technology, applied in the field of medical materials, can solve the problem of lack of anti-cancer efficiency, biocompatibility, etc., and achieve good photothermal effect and good biocompatibility.

Active Publication Date: 2022-02-18
CAPITAL NORMAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Although the existing temperature-responsive materials already have a good therapeutic effect, they still do not have sufficient anti-cancer efficiency and good biocompatibility properties.

Method used

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  • A photothermal nanomaterial capable of responding to temperature and its preparation method
  • A photothermal nanomaterial capable of responding to temperature and its preparation method
  • A photothermal nanomaterial capable of responding to temperature and its preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] 1) Synthesis of photothermal nanomaterial polydopamine (PDA-NPs): Weigh 0.05g dopamine (DA) powder and disperse it in a mixed solvent of 10mL distilled water and 4mL alcohol. After fully stirring and mixing, add 0.1mL ammonia water dropwise, Protect from light, stir well, carry out oxidative self-polymerization at room temperature for 20 hours, centrifuge the reaction solution at a speed of 12000r / min, pour off the supernatant, add alcohol and ultrasonically disperse and clean, repeat three times. The final product was obtained after vacuum drying at 60°C for 12 hours.

[0027] 2), Copolymerization of temperature-responsive monomers and modified monomers with polydopamine: disperse 0.004g polydopamine (PDA-NPs) in 2mL distilled water, ultrasonically disperse for 30min; weigh 0.5420g 3-[N,N-di Methyl-[2-(2-methylprop-2-enoyloxy)ethyl]ammonium]propane-1-sulfonic acid inner salt (SBMA), 0.0188g dimethylaminoethyl methacrylate (DMAEMA) and 0.011g N,N'-methylenebisacrylamid...

Embodiment 2

[0029] 1) Synthesis of photothermal nanomaterial polydopamine (PDA-NPs): Weigh 0.05g dopamine (DA) powder and disperse it in a mixed solvent of 10mL distilled water and 4mL alcohol. After fully stirring and mixing, add 0.1mL ammonia water dropwise, Protect from light, stir well, carry out oxidative self-polymerization at room temperature for 20 hours, centrifuge the reaction solution at a speed of 12000r / min, pour off the supernatant, add alcohol and ultrasonically disperse and clean, repeat three times. The final product was obtained after vacuum drying at 60°C for 12 hours.

[0030] 2), Copolymerization of temperature-responsive monomers and modified monomers with polydopamine: disperse 0.004g polydopamine (PDA-NPs) in 2mL distilled water, ultrasonically disperse for 30min; weigh 0.5313g 3-[N,N-di Methyl-[2-(2-methylprop-2-enoyloxy)ethyl]ammonium]propane-1-sulfonic acid inner salt (SBMA), 0.0162g dimethylaminoethyl methacrylate (DMAEMA) and 0.011g N,N'-methylenebisacrylamid...

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Abstract

The invention discloses a photothermal nanometer material capable of responding to temperature and a preparation method thereof. The present invention uses nano-material polydopamine (PDA‑NPs) as a base material, and 3‑[N, N‑dimethyl‑ [2‑(2‑methylacryl‑2‑alkenoyloxy)ethyl]ammonium]propane‑1‑sulfonic acid inner salt (SBMA) is copolymerized and chemically cross-linked to form a gel. The temperature-responsive photothermal nanomaterial prepared by the present invention has sensitive response performance of ambient temperature value, good photothermal effect, self-healing ability and cell / tissue adhesion, and can be applied to control drug delivery, sensor and tissue Engineering and other fields.

Description

technical field [0001] The invention belongs to the technical field of medical materials, and in particular relates to a photothermal nanometer material capable of responding to temperature and a preparation method thereof. Background technique [0002] Temperature-responsive smart hydrogels can respond to external stimuli and change their structures or properties according to environmental changes; thus, these materials hold great promise for a wide range of applications, such as controlled drug delivery, sensors, and tissue engineering. Among these stimuli, near-infrared light has remarkable deep tissue penetrating ability with little damage to biological specimens, and has been reported to be suitable for biological applications and living tissues. Furthermore, light can be applied instantaneously, making light-responsive hydrogels extremely advantageous in various applications. [0003] Although the existing temperature-responsive materials already have good therapeutic...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08F283/00C08F220/34C08F220/38C08F222/38
CPCC08F283/00
Inventor 黄潇楠朱悦
Owner CAPITAL NORMAL UNIVERSITY
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