Efficient hemostatic material capable of promoting wound healing and preparation method thereof

A hemostatic material and wound healing technology, applied in the field of high-efficiency hemostatic materials and their preparation, can solve the problems of lack of hemostatic efficiency and biocompatibility characteristics, and achieve the effects of promoting wound healing, shortening wound healing time, and high coagulation efficiency

Inactive Publication Date: 2019-03-29
CAPITAL NORMAL UNIVERSITY +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Although the existing inorganic hemostatic materials have good hemostatic properties, they still do not have sufficient hemostatic efficiency and biocompatibility properties

Method used

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  • Efficient hemostatic material capable of promoting wound healing and preparation method thereof
  • Efficient hemostatic material capable of promoting wound healing and preparation method thereof
  • Efficient hemostatic material capable of promoting wound healing and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] (1) Spherical porous CaCO 3 Preparation of powder: Weigh 16.6g CaCl successively 2 , 15.6g Na 2 CO 3 , were fully dissolved in 300mL distilled water. Under vigorous stirring at room temperature, the Na 2 CO 3 Solution (0.1M) was quickly poured into CaCl 2 (0.1M) solution. The resulting precipitate was washed 3 times with distilled water, filtered with suction, and dried in air at room temperature.

[0030] (2) Dissolving of 1% chitosan: Weigh 5g chitosan in 1L flask, add 500mL distilled water, under the condition of magnetic stirring, dropwise add the existing 1wt% CH 3 COOH solution 5g. Continue to stir for 12 hours until the chitosan is fully dissolved and the solution is clear and transparent.

[0031] (3)CaCO 3 Compounding with chitosan: under the effect of magnetic stirring, the CaCO prepared by 10g step (1) 3 The powder was dispersed in 200mL distilled water, then poured into 200mL chitosan solution, and kept stirring until the powder was fully disperse...

Embodiment 2

[0035] (1) Spherical porous CaCO 3 Preparation: Weigh 11.0g CaCl in turn 2 , 10.5g Na 2 CO 3 , were fully dissolved in 300mL distilled water. Under vigorous stirring at room temperature, the Na 2 CO 3 Solution (0.33M) was quickly poured into CaCl 2 (0.33M) solution. The resulting precipitate was washed 3 times with distilled water, filtered with suction, and dried in air at room temperature.

[0036] (2) Dissolution of 1% chitosan: Weigh 5g chitosan in a 1L flask, add 500mL distilled water, and add the existing 1% CH 3 COOH solution 5g. Continue to stir for 12 hours until the chitosan is fully dissolved and the solution is clear and transparent.

[0037] (3)CaCO 3 Compounding with chitosan: under the action of magnetic stirring, 10g CaCO 3 After the powder is decomposed in 200mL distilled water, pour into 200mL chitosan solution. Stir continuously until the powder is well dispersed in the solution and then freeze.

[0038] (4) Processing of the composite material:...

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PUM

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Abstract

The invention discloses an efficient hemostatic material capable of promoting wound healing and a preparation method thereof. The method comprises that a spherical porous CaCO3 powder dispersion liquid and a chitosan solution are mixed, stirred, compounded, then freeze-dried and ground into powder, and then the efficient hemostatic material capable of promoting wound healing is obtained. Porous CaCO3 as a base material is compounded with chitosan and then ground into powder, and excellent hemostatic performance and wound healing promoting effect are achieved. The material achieves high blood coagulation efficiency and shortens the blood coagulation time to 16 s. By timingly spreading an appropriate amount of the powder evenly on a mice wound having 1 cm*1 cm of skin removed, the wound canbe healed in 9 d, and the healing time of the wound is greatly shortened. The prepared efficient hemostatic material capable of promoting wound healing has good biocompatibility, non-toxicity and ideal low-hemolysis performance.

Description

technical field [0001] The invention belongs to the technical field of inorganic material preparation, and in particular relates to a high-efficiency hemostatic material capable of promoting wound healing and a preparation method thereof. The present invention uses porous CaCO 3 As a base material, compounded with chitosan and ground into powder to obtain a highly efficient hemostatic material that can promote wound healing. Background technique [0002] Uncontrolled hemorrhage is the leading cause of death in wars, car accidents, and other accidents. The development of emergency life-saving hemostatic materials that can stop bleeding in a short time can effectively reduce the death caused by bleeding. Therefore, research and development of hemostatic materials with good hemostatic effect and low side effects is an urgent problem to be solved. [0003] Inorganic hemostatic material, with long-term physical and chemical stability, has the effect of accelerating hemostasis ...

Claims

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Application Information

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IPC IPC(8): A61L15/42A61L15/18A61L15/28A61L15/62
CPCA61L15/18A61L15/28A61L15/42A61L15/425A61L15/62A61L2400/04C08L5/08
Inventor 黄潇楠朱悦郝威威赵莉
Owner CAPITAL NORMAL UNIVERSITY
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