Purpose of modified thymosin [beta]4 in treatment of radiation enteritis

A radioactive enteritis and thymosin technology, applied in the field of disease treatment, can solve problems such as poor prognosis and large patient injuries

Active Publication Date: 2019-09-10
BEIJING NORTHLAND BIOTECH
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Problems solved by technology

Once it occurs, the clinical treatment mainly depends on surgery, which not only causes great

Method used

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  • Purpose of modified thymosin [beta]4 in treatment of radiation enteritis
  • Purpose of modified thymosin [beta]4 in treatment of radiation enteritis
  • Purpose of modified thymosin [beta]4 in treatment of radiation enteritis

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Example Embodiment

[0040] Example

[0041] In this example, a mouse radiation enteritis model was used to evaluate the effect of modified recombinant human thymosin β4 on the treatment of radiation enteritis.

[0042] 1. Materials and Methods

[0043] 1.1 Drugs:

[0044] Modified recombinant human thymosin β4 (hereinafter referred to as rhG-Tβ4 and rhA-Tβ4), provided by Beijing Northland Biotechnology Co., Ltd., batch number C-20180101 (the sequence is shown in SEQ ID NO: 1) And C-20180315 (the sequence is shown in SEQ ID NO: 2); Specification: 100μg / piece. Use normal saline to make the required concentration before use.

[0045] The natural structure of human thymosin β4 was chemically synthesized by Shanghai Peptix Biotechnology Co., Ltd. (hereinafter referred to as cTβ4), and it was prepared to the required concentration with normal saline before use.

[0046] instrument:

[0047] EG1160 paraffin embedding machine, a product of Leica, Germany;

[0048] RM2255 slicer, a product of Leica, Germany;

[0049...

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Abstract

The invention is entitled as "a purpose of modified thymosin [beta]4 in treatment of radiation enteritis", and relates to the technical field of treatment of radiation enteritis diseases. A technicalproblem to be solved is that: the radiation enteritis is mainly treated by surgery in current clinical treatment, which has a relatively large injury to a patient, as well as has complications, and isalso poor after curing; although studies show that the thymosin [beta]4 with a natural structure has a certain therapeutic effect on colitis, but is higher in dosage, and a structure of the selectedmodified thymosin [beta]4 of the invention is compared with that of natural thymosin [beta]4, a dosage can be significantly reduced, and the modified thymosin [beta]4 is of great significance for thetreatment of the radiation enteritis. Main points of a technical scheme are that: a dosage and a treatment effect are compared by mainly using the structure of the modified thymosin [beta]4 and the natural thymosin [beta]4 and through research of an animal model of the radiation enteritis; and in a primary purpose aspect, the modified thymosin [beta]4of the invention is used for the purpose in treating the radiation enteritis in a subject.

Description

technical field [0001] The present invention relates to the field of disease treatment. Specifically, the present invention relates to the use of modified thymosin β4 for treating radiation enteritis in a subject (for example, a human), and the preparation of a drug for treating radiation enteritis in a subject (for example, a human). Drug use. The present invention also relates to a method for treating radiation enteritis, which includes the step of administering the modified thymosin β4 to a subject in need thereof. Background technique [0002] Statistics from Shadad AK et al. (Gastrointestinal radiation injury: prevention and treatment. World J Gastroenterol, 2013, 19: 199-208) show that radiation therapy plays a key role in the treatment of tumors, and about 70% of tumor patients have received radiation With the popularization of radiation therapy in malignant tumors, the incidence of radiation enteritis (RE) is increasing year by year (Clinical risk factors for late ...

Claims

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Application Information

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IPC IPC(8): A61K38/22A61K9/08A61K9/19A61P1/00A61P1/12
CPCA61K38/2292A61K9/0019A61K9/08A61K9/19A61P1/00A61P1/12
Inventor 聂李亚许松山马素永马杉姗汤晓闯
Owner BEIJING NORTHLAND BIOTECH
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