Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Purpose of modified thymosin [beta]4 in treatment of radiation enteritis

A radioactive enteritis and thymosin technology, applied in the field of disease treatment, can solve problems such as poor prognosis and large patient injuries

Active Publication Date: 2019-09-10
BEIJING NORTHLAND BIOTECH
View PDF9 Cites 2 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Once it occurs, the clinical treatment mainly depends on surgery, which not only causes great damage to the patient, but also has many complications, and the prognosis is relatively poor.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Purpose of modified thymosin [beta]4 in treatment of radiation enteritis
  • Purpose of modified thymosin [beta]4 in treatment of radiation enteritis
  • Purpose of modified thymosin [beta]4 in treatment of radiation enteritis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0041] In this example, the effect of the modified recombinant human thymosin β4 on the treatment of radiation enteritis was evaluated through a mouse model of radiation enteritis.

[0042] 1. Materials and Methods

[0043] 1.1 Drugs:

[0044] Modified recombinant human thymosin β4 (hereinafter referred to as rhG-Tβ4 and rhA-Tβ4), provided by Beijing Northland Biotechnology Co., Ltd., the batch number is C-20180101 (its sequence is shown in SEQ ID NO: 1) and C-20180315 (its sequence is shown in SEQ ID NO: 2); specification: 100 μg / bottle. Prepare the required concentration with physiological saline immediately before use.

[0045] The natural structure of human thymosin β4 is chemically synthesized by Shanghai Taishi Biotechnology Co., Ltd. (hereinafter referred to as cTβ4), and it is prepared to the required concentration with normal saline before use.

[0046] instrument:

[0047] EG1160 paraffin embedding machine, a product of Leica, Germany;

[0048] RM2255 slicer, ...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention is entitled as "a purpose of modified thymosin [beta]4 in treatment of radiation enteritis", and relates to the technical field of treatment of radiation enteritis diseases. A technicalproblem to be solved is that: the radiation enteritis is mainly treated by surgery in current clinical treatment, which has a relatively large injury to a patient, as well as has complications, and isalso poor after curing; although studies show that the thymosin [beta]4 with a natural structure has a certain therapeutic effect on colitis, but is higher in dosage, and a structure of the selectedmodified thymosin [beta]4 of the invention is compared with that of natural thymosin [beta]4, a dosage can be significantly reduced, and the modified thymosin [beta]4 is of great significance for thetreatment of the radiation enteritis. Main points of a technical scheme are that: a dosage and a treatment effect are compared by mainly using the structure of the modified thymosin [beta]4 and the natural thymosin [beta]4 and through research of an animal model of the radiation enteritis; and in a primary purpose aspect, the modified thymosin [beta]4of the invention is used for the purpose in treating the radiation enteritis in a subject.

Description

technical field [0001] The present invention relates to the field of disease treatment. Specifically, the present invention relates to the use of modified thymosin β4 for treating radiation enteritis in a subject (for example, a human), and the preparation of a drug for treating radiation enteritis in a subject (for example, a human). Drug use. The present invention also relates to a method for treating radiation enteritis, which includes the step of administering the modified thymosin β4 to a subject in need thereof. Background technique [0002] Statistics from Shadad AK et al. (Gastrointestinal radiation injury: prevention and treatment. World J Gastroenterol, 2013, 19: 199-208) show that radiation therapy plays a key role in the treatment of tumors, and about 70% of tumor patients have received radiation With the popularization of radiation therapy in malignant tumors, the incidence of radiation enteritis (RE) is increasing year by year (Clinical risk factors for late ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K38/22A61K9/08A61K9/19A61P1/00A61P1/12
CPCA61K38/2292A61K9/0019A61K9/08A61K9/19A61P1/00A61P1/12
Inventor 聂李亚许松山马素永马杉姗汤晓闯
Owner BEIJING NORTHLAND BIOTECH
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com