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Method of measuring primary drug content of Azasetron HCI

A technology for the determination of azasetron hydrochloride and its determination method, which is applied in the field of determination of the main drug content of azasetron hydrochloride, can solve the problems of artificial pressure and high labor cost, unclear titration end point, and impact on detection efficiency, etc., achieving efficiency and The effect of obvious cost, avoiding human error, and accurate results

Inactive Publication Date: 2019-09-10
SHANGHAI SINE WANXIANG PHARMA +1
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] At present, for the determination of the main drug content of azasetron hydrochloride, the current implementation standard is still the WS1-(X-319)-2004Z ministerial standard nearly 20 years ago. Due to the long history of the standard, manual titration is still used, and the titration end point Not obvious, artificial judgment of the titration end point requires a high concentration of thought, which will inevitably lead to the risk of misjudgment; and the human pressure and labor cost are high, which seriously affects the detection efficiency

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  • Method of measuring primary drug content of Azasetron HCI
  • Method of measuring primary drug content of Azasetron HCI

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Embodiment

[0019] A method for determining the content of azasetron hydrochloride main drug is provided. Water is used as a dissolution medium, and the absorbance of a sample is measured by ultraviolet spectrophotometry at a wavelength of 305 nm, and the content of azasetron hydrochloride main drug is calculated by an external standard method.

[0020] Specifically, the assay method of the main drug content of azasetron hydrochloride comprises the following steps:

[0021] (1) Preparation of the test solution: get the main drug of azasetron hydrochloride, which is approximately equivalent to 20 mg of azasetron hydrochloride, accurately weighed, placed in a 200ml measuring bottle, dissolved in water and diluted to the mark, shaken up, filter

[0022] (2) Preparation of reference solution: Take 20 mg of azasetron hydrochloride reference substance, weigh it accurately, place it in a 200ml measuring bottle, dissolve it in water and dilute to the mark, and shake well.

[0023] (3) Take the a...

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Abstract

The present invention discloses a method of measuring primary drug content of Azasetron HCI. With water as a dissolution medium, UV spectrophotometry is adopted at 305nm wavelength for measuring absorbance of a sample and the primary drug content of Azasetron HCI is calculated with an external standard method. The present invention is a method of calculating the primary drug content of Azasetron HCI with the external standard method by adopting the UV spectrophotometry. Via verification, the method is currently good, and its measuring results are accurate and reliable. When simultaneous measurement is required for multiple batches, the method can greatly reduce the cost of measurement and shorten the time of measurement. Since instrumental analysis is adopted, the method can decrease deviations caused by inaccurate artificial judgment of an end point in an experimental process.

Description

technical field [0001] The invention relates to the technical field of chemical analysis, in particular to a method for determining the content of azasetron hydrochloride main drug. Background technique [0002] Azasetron hydrochloride, alias N-(1-azabicyclo2.2.2oct-8-yl)-6-chloro-4-methyl-3-oxo-3,4-dihydro-2H-1, 4-Benzoxazine-8-carboxamide hydrochloride is a colorless or almost colorless clear aqueous solution, which is an auxiliary anticancer drug, with the molecular formula: Cl7H20ClN303·HCI. Azasetron hydrochloride is a potent, highly selective, safe to use, and low side effect 5-HT3 receptor antagonist, which is used for the prevention and treatment of nausea and vomiting caused by tumor chemotherapy, radiotherapy and surgery. The drug is characterized by Not only can it effectively suppress acute nausea and vomiting, but it also has a better effect on delayed nausea and vomiting. [0003] At present, for the determination of the main drug content of azasetron hydroch...

Claims

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Application Information

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IPC IPC(8): G01N21/33
CPCG01N21/33
Inventor 胡岩钱磊高静
Owner SHANGHAI SINE WANXIANG PHARMA