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Method for detecting content of tranexamic acid preparation

A technology of tranexamic acid and determination method, applied in the field of chemical analysis, can solve the problems of low detection efficiency, cumbersome steps, complicated experimental methods and the like

Pending Publication Date: 2021-08-20
SHANGHAI SINE WANXIANG PHARMA +1
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] The present invention proposes a method for measuring the content of tranexamic acid preparations in order to solve the defects of complex experimental methods, cumbersome steps and low detection efficiency in the existing detection methods

Method used

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  • Method for detecting content of tranexamic acid preparation

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Experimental program
Comparison scheme
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Embodiment

[0019] A method for determining the content of the main drug in tranexamic acid preparations is provided, comprising the steps of:

[0020] (1) Preparation of the test solution: take the tranexamic acid crude drug, approximately equivalent to 50 mg of tranexamic acid, accurately weigh it, put it in a 25ml measuring bottle, add water to dissolve and dilute to the mark, shake well, and filter;

[0021] (2) Preparation of control solution: take 25 mg of tranexamic acid reference substance, weigh it accurately, put it in a 25 ml measuring bottle, dissolve it in water and dilute to the mark, and shake well;

[0022] (3) Take the above-mentioned test solution and control solution, measure the absorbance at a wavelength of 220 nm by ultraviolet photometry, and calculate the content by the external standard method.

[0023] In this embodiment, the ultraviolet spectrophotometry method is: referring to the ultraviolet-visible spectrophotometry method (Chinese Pharmacopoeia 2015 Edition ...

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Abstract

The invention discloses a method for detecting the content of a main drug in a tranexamic acid preparation.Water is taken as a solution, the absorbance of a sample is detected at the wavelength of 220 nm by adopting an ultraviolet spectrophotometric method, and the content of the main drug in the tranexamic acid preparation is calculated by adopting an external standard method. According to the detection method disclosed by the invention, the tranexamic acid content is detected by adopting the ultraviolet spectrophotometric method and the external standard method, verification proves that the tranexamic acid content is good, and the result is accurate and reliable; and when multiple batches need to be detected at the same time, the detection cost can be greatly reduced, the detection time can be shortened, errors caused by complex and tedious steps of an existing experiment method in the experiment process are reduced, and the detection efficiency is improved.

Description

technical field [0001] The invention relates to the technical field of chemical analysis, in particular to a method for determining the content of main ingredients in tranexamic acid preparations. Background technique [0002] Tranexamic acid is a synthetic amino acid antifibrinolytic drug, and its main mechanism of action is to achieve hemostatic effect by inhibiting the activation of proteolysin and plasminogen. Clinical drugs include tranexamic acid tablets, tranexamic acid injections and tranexamic acid capsules. In addition, studies have found that tranexamic acid can inhibit pigmentation caused by ultraviolet radiation, and achieve the effect of whitening and freckle removal. At present, tranexamic acid has been used as a drug for the treatment of chloasma clinically. As a freckle removing agent, tranexamic acid can be added to freckle removing and whitening cosmetics. Tranexamic acid is also an illegal additive in health foods that claim to remove chloasma. Tranex...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N21/33
CPCG01N21/33
Inventor 胡岩高静倪晓兰王艳黄孝俊
Owner SHANGHAI SINE WANXIANG PHARMA