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A multimodal imaging device combining photoacoustic and fiber laser speckle

A multi-modal imaging and laser speckle technology, which is applied in medical science, diagnosis, catheterization, etc., can solve problems such as no structural parameters, and achieve the effect of reducing measurement steps and time, and reducing size

Active Publication Date: 2021-07-09
NANJING UNIV OF AERONAUTICS & ASTRONAUTICS
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Problems solved by technology

[0005] At present, although photoacoustic imaging and laser speckle imaging have been realized, due to the limitation of operating equipment, there is no multi-modal non-invasive method that can not only measure the structural parameters of tissues and cells in blood vessels, but also measure blood oxygen parameters. imaging device

Method used

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  • A multimodal imaging device combining photoacoustic and fiber laser speckle
  • A multimodal imaging device combining photoacoustic and fiber laser speckle
  • A multimodal imaging device combining photoacoustic and fiber laser speckle

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Embodiment Construction

[0024] Such as figure 1 with figure 2 As shown, taking the experimental detection of mouse brain tissue as an example, the device of the present invention includes: a light source module 1 , a motor control module 2 , and a data acquisition module 3 .

[0025] The host computer 30 first controls the pulse laser 10 to set parameters such as the output power, pulse repetition frequency, and pulse width of the pulse laser. The trigger signal for acoustic signal acquisition; the other part of the laser light is transmitted to the dichroic mirror 13. The dichroic mirror can allow the 532nm laser to penetrate, but block the vertical reflection of the laser emitted by the 632.8nm He-Ne laser source 11, so as to realize the fusion of the two laser beams. The fused laser light is transmitted to the plane mirror 14 and sent to the motor control module 2 through the vertical reflection of the plane mirror.

[0026] The vertically reflected laser beam is expanded and diverged by the p...

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Abstract

The invention discloses a multi-mode imaging device combining photoacoustic and fiber laser speckle, comprising: a light source module, a motor control module and a data acquisition module. The invention has reasonable structure and simple structure, realizes real-time synchronous detection of blood vessel structure, blood flow and blood oxygen in the same field of view, effectively combines high-resolution photoacoustic imaging technology with endoscopic laser speckle imaging technology, greatly improves The measurement steps and time of different parameters are shortened, which provides a strong support for the clinical diagnosis and treatment of tumors and vascular diseases in the future.

Description

technical field [0001] The invention relates to the technical field of multimodal non-invasive imaging, in particular to a multimodal imaging device combining photoacoustic and fiber laser speckle. Background technique [0002] Photoacoustic imaging technology is a new type of non-invasive imaging technology that has developed rapidly in recent years. Based on the principle of photoacoustic effect, this technology is a non-invasive high-resolution imaging method that obtains two-dimensional tomography or three-dimensional stereoscopic tissue. The photoacoustic effect refers to the phenomenon that after an object is subjected to light with periodically changing intensity, it will expand with heat and contract with cold due to the periodic temperature change inside the object, thereby generating ultrasonic waves. Photoacoustic imaging technology combines the characteristics of optical imaging and acoustic imaging technology, and has the characteristics of high resolution, high...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61B5/02A61B5/026A61B5/00
CPCA61B5/0035A61B5/0095A61B5/02028A61B5/0261
Inventor 李韪韬王康张欢冯宇赵月梅
Owner NANJING UNIV OF AERONAUTICS & ASTRONAUTICS
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