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Sodium alginate microsphere filling material and preparation method thereof

A filling material, sodium alginate technology, applied in the field of biomedicine, can solve the problems of high biotoxicity of cross-linking agents, injection beauty hazards, etc., and achieve the effect of facilitating industrial production, overcoming biotoxicity, and good shaping effect

Inactive Publication Date: 2019-09-20
科先医疗科技(苏州)有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the high biological toxicity of the cross-linking agent, it has caused potential danger to injection cosmetics.

Method used

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  • Sodium alginate microsphere filling material and preparation method thereof
  • Sodium alginate microsphere filling material and preparation method thereof
  • Sodium alginate microsphere filling material and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0033] A sodium alginate microsphere filling material, the filling material is made of raw materials comprising the following parts by weight: 32 parts of sodium alginate, 10 parts of gelatin, 0.6 part of chitosan, 0.2 part of carboxymethyl cellulose, collagen 5 parts protein, 120 parts normal saline, 10 parts polylactic acid.

[0034] The preparation method of the sodium alginate microsphere filling material comprises the following steps: (1) heating and melting the gelatin, adding chitosan therein, and mixing uniformly under stirring at 3000-5000rpm to obtain a premix; (2) mixing Sodium alginate, adsorbent and cross-linking agent were dissolved in physiological saline, and mixed uniformly to obtain a filling solution; (3) adding the premixed solution into liquid paraffin containing 1% Tween 80, stirring and emulsifying for 30 minutes, To obtain a pre-mixed emulsion, add the filling solution to liquid paraffin containing 1% Tween 80, stir and emulsify for 30 minutes to obtain...

Embodiment 2

[0037] A sodium alginate microsphere filling material, the filling material is made of raw materials comprising the following parts by weight: 32 parts of sodium alginate, 15 parts of gelatin, 0.6 part of chitosan, 0.2 part of carboxymethyl cellulose, collagen 5 parts protein, 120 parts normal saline, 10 parts polylactic acid.

[0038] The preparation method of the sodium alginate microsphere filling material comprises the following steps: (1) heating and melting the gelatin, adding chitosan therein, and mixing uniformly under stirring at 3000-5000rpm to obtain a premix; (2) mixing Sodium alginate, adsorbent and cross-linking agent were dissolved in physiological saline, and mixed uniformly to obtain a filling solution; (3) adding the premixed solution into liquid paraffin containing 1% Tween 80, stirring and emulsifying for 30 minutes, To obtain a pre-mixed emulsion, add the filling solution to liquid paraffin containing 1% Tween 80, stir and emulsify for 30 minutes to obtain...

Embodiment 3

[0041] A sodium alginate microsphere filling material, the filling material is made of raw materials comprising the following parts by weight: 32 parts of sodium alginate, 15 parts of gelatin, 3 parts of chitosan, 0.2 part of carboxymethyl cellulose, collagen 5 parts protein, 120 parts normal saline, 10 parts polylactic acid.

[0042] The preparation method of the sodium alginate microsphere filling material comprises the following steps: (1) heating and melting the gelatin, adding chitosan therein, and mixing uniformly under stirring at 3000-5000rpm to obtain a premix; (2) mixing Sodium alginate, adsorbent and cross-linking agent were dissolved in physiological saline, and mixed uniformly to obtain a filling solution; (3) adding the premixed solution into liquid paraffin containing 1% Tween 80, stirring and emulsifying for 30 minutes, To obtain a pre-mixed emulsion, add the filling solution to liquid paraffin containing 1% Tween 80, stir and emulsify for 30 minutes to obtain ...

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Abstract

The invention provides a sodium alginate microsphere filling material. The filling material is prepared from, by weight, 30-50 parts of sodium alginate, 5-15 parts of gelatin, 0.5-5 parts of chitosan, 0.1-3 parts of an adsorbing agent, 5-10 parts of a cross-linking agent and 100-200 parts of normal saline. High biocompatibility and mutual crosslinking of components of the sodium alginate microsphere filling material are realized, degradation of hyaluronic acid is effectively prevented, plasticity stability in body filling is realized, a great plastic effect is achieved, and the defect of proneness to causing biotoxicity in use of cross-linked hyaluronic acid is overcome.

Description

technical field [0001] The invention belongs to the field of biomedicine, and in particular relates to a sodium alginate microsphere filling material and a preparation method thereof. Background technique [0002] In today's society, plastic surgery is not only a patent in the field of damage repair, but also a means for people to pursue beauty. With the improvement of living standards and the development of plastic surgery technology, the way to obtain beauty through plastic surgery has gradually been accepted and trusted by people. The people receiving plastic surgery have also spread from entertainment stars engaged in performing arts to ordinary people. From the huge demand market for plastic surgery materials, we can predict their good development prospects. [0003] Various methods of plastic surgery are springing up like bamboo shoots after the rain, including traditional plastic surgery, microsurgery technology, skin expansion technology and injection transplantatio...

Claims

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Application Information

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IPC IPC(8): A61L27/18A61L27/20A61L27/22A61L27/50
CPCA61L27/18A61L27/20A61L27/222A61L27/50A61L2400/06C08L5/04C08L5/08C08L67/04
Inventor 吕国军
Owner 科先医疗科技(苏州)有限公司
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