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Method for screening and verifying taurine being molecular marker of low-dose ionizing radiation injury of human body

A technology of molecular markers and radiation damage, applied in the direction of measuring devices, material separation, and analysis of materials, can solve the problems that animals cannot be fully applied to humans, and achieve the effects of low environmental risk, short time, and high reliability

Pending Publication Date: 2019-09-20
NANHUA UNIV
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Problems solved by technology

However, there are certain differences in the metabolism of different species, so the relevant research results on animals cannot be fully applied to humans.

Method used

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  • Method for screening and verifying taurine being molecular marker of low-dose ionizing radiation injury of human body

Examples

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Embodiment 1

[0038] In a uranium mine in a certain province, 32 front-line workers exposed to radiation were used as the exposure group, and 32 office workers who did not receive radiation exposure were used as the control group by reviewing the mine records. The age and gender composition of the two groups were similar. Inclusion criteria: ①All staff members of the uranium mine; ②Those who have completed the questionnaire on the health information form of uranium mine workers (see attached table 1); ③Those who have collected blood samples. Exclusion criteria: ①those with diabetes; ②those with severe hematological diseases; ③those with long-term medication history. A centrifuge tube filled with heparin sodium anticoagulant was used for fasting sampling, and 2 ml of whole blood was collected. The collected blood sample was centrifuged at room temperature for 5 min (3000 rpm), and 0.2 ml of the supernatant was taken into a centrifuge tube. A total of 4 tubes were packed and stored in a -80°C...

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Abstract

The invention relates to a method for screening and verifying taurine being a molecular marker of a low-dose ionizing radiation injury of a human body. A first-line worker is used as a low-dose radiation exposure group, office personnel are used as a control group, and the screening of low-dose radiation injury molecular markers is performed on low-dose radiation occupational exposure people based on a non-targeted metabonomics method. It is screened and verified that the taurine can be used as a molecular marker of low-dose radiation injury of a human body, and compared with other molecular markers of radiation injury, the taurine can reflect the biological injury effect of professional people under low-dose radiation irradiation more systematically; samples used for taurine detection, such as blood, urine and the like, are easy to obtain, and therefore, the method has practical significance in application, and has the multiple advantages of short required time, strong specificity, high reliability, low environmental risk and the like.

Description

technical field [0001] The invention belongs to the technical field of low-dose radiation damage evaluation, and in particular relates to a screening and verification method for taurine, a molecular marker of low-dose ionizing radiation damage. Background technique [0002] Ionizing radiation directly or indirectly damages cells and tissues by generating free radicals, and has adverse effects on the body, causing inflammation, cancer and even death. With the wide application of nuclear power, isotopes and radiotherapy, people have more and more opportunities to be exposed to low-dose ionizing radiation. Since the Fukushima nuclear accident in 2011, the impact of low-dose radiation on human health has attracted widespread attention. [0003] The health effects of high-dose ionizing radiation have been relatively clear, but the biological effects and damage markers caused by low-dose radiation have not yet been ascertained. Individuals exposed to low doses of ionizing radiati...

Claims

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Application Information

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IPC IPC(8): G01N30/06G01N30/88G01N30/86
CPCG01N30/06G01N30/88G01N30/8696
Inventor 丁德馨胡南奉水东龙鼎新刘良丽陈香兰
Owner NANHUA UNIV
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