A biomarker metabolic pathway and its analysis method and application

A technology of biomarkers and pathways, which is applied in the field of functional analysis of metabolic biomarkers of diseases, can solve problems such as incompletely clear functions of metabolic biomarkers of depression, and achieve the effect of optimized diagnosis

Active Publication Date: 2021-07-27
SHANXI UNIV
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Problems solved by technology

However, the function of metabolic biomarkers in depression is not fully understood

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  • A biomarker metabolic pathway and its analysis method and application
  • A biomarker metabolic pathway and its analysis method and application
  • A biomarker metabolic pathway and its analysis method and application

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[0022] In order to further describe the present invention in detail, the following specific examples are given, but only to illustrate the present invention, not to limit the scope of the present invention.

[0023] 1. Metabolic biomarkers-enzyme network analysis of depression

[0024] Information and structures of identified metabolic biomarkers of depression were obtained from the Human Metabolomics Database (HMDB), and the structures of these compounds were downloaded from PubChem. HMDB also collected enzymes related to metabolic biomarkers, and the functional categories of these proteins were extracted from the UniProt database. Use the network analysis module of Cytoscape to calculate the network centrality of nodes, and nodes represent metabolic markers and enzymes; in undirected networks, centrality is defined as the number of adjacent nodes, and centrality is used to evaluate the importance of nodes in the network . For example, the centrality of an enzyme node is th...

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Abstract

The invention belongs to the technical field of functional analysis methods of disease metabolic biomarkers, and provides a biomarker metabolic pathway and an analysis method. The metabolic biomarkers are: stearic acid, phytosphingosine, glycine, glutamine and phospholipids; the targets of the metabolic biomarkers are targets related to the nervous system, immune response and endocrine of depression disease protein; the metabolic pathway is PI3K-Akt signaling pathway, mTOR signaling pathway, MAPK signaling pathway, erbB signaling pathway, neurotrophin signaling pathway, Rap1 signaling pathway and Ras signaling pathway. A functional network analysis method suitable for the characteristics of depression was established. The clinical application of these biomarkers can help optimize the diagnosis of depression and provide some valuable clues for subsequent research on the network function of depression.

Description

technical field [0001] The invention belongs to the technical field of functional analysis methods of disease metabolic biomarkers, and relates to a biomarker metabolic pathway and its analysis method and application, in particular to a depression metabolic biomarker metabolic pathway and analysis method based on network pharmacology. Background technique [0002] Metabolomics is a rapidly developing omics technology following genomics, transcriptomics and proteomics, and is an important part of systems biology. Integrality is the basic point of view of metabolomics theory, which mainly uses nuclear magnetic resonance, mass spectrometry and other technical means to study the changes and laws of metabolites after biological systems are stimulated or disturbed. Changes in the levels of these metabolites are closely related to related metabolic pathways. By studying the changes in metabolite levels and related metabolic pathways, we can understand the changes in the body as a w...

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N33/68
CPCG01N33/6893G01N2800/304
Inventor 高耀秦雪梅田俊生令狐婷
Owner SHANXI UNIV
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