Peroxy bond-containing compound Oleracone I in parslane herb as well as extraction and separation method and application of compound

A separation method and compound technology, which can be applied in the directions of organic chemistry, drug combination, non-central analgesics, etc., can solve the problems of low structural novelty, and achieve the effects of environmental protection of the process method, simple and fast operation method

Active Publication Date: 2019-10-01
LIAONING UNIV OF TRADITIONAL CHINESE MEDICINE
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  • Abstract
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Problems solved by technology

[0004] At present, most of the chemical components isolated from purslane are known, and the structural novelty is low. Therefore, the development and isolation of new compounds in purslane are urgently needed

Method used

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  • Peroxy bond-containing compound Oleracone I in parslane herb as well as extraction and separation method and application of compound
  • Peroxy bond-containing compound Oleracone I in parslane herb as well as extraction and separation method and application of compound
  • Peroxy bond-containing compound Oleracone I in parslane herb as well as extraction and separation method and application of compound

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Embodiment Construction

[0030] The present invention provides a new compound with the molecular formula C 18 H 18 O 6 , Named oleracone I, chemical formula:

[0031] .

[0032] The new compound is named oleracone I according to the structure. Table 1 shows the nuclear magnetic data of the new compound: 1 H-NMR and 13 C-NMR in deuterated DMSO.

[0033] Table 1 NMR data of new compounds ( 1 H-NMR and 13 C-NMR in deuterated DMSO).

[0034]

[0035] The structure identification of the compound of the present invention Figure 1-10 .

[0036] Oleracone I: yellow-brown powder, easily soluble in methanol. UV(MeOH)λ max : 284, 214 nm. IR (KBr) v max 2920, 2850, 2360, 1670, 1610, 1460, 1215, 1160, 831, 762 cm -1 . HRESI(+)TOFMS gives m / z: 331.1141 [M + H] + The quasi-molecular ion peak has a molecular weight of 331.1137. Combine 1 H-NMR, 13 C-NMR and DEPT data, speculate that the possible molecular formula of the compound is C 18 H 18 O 6 , The degree of unsaturation is 10. 13 C-NMR spectrum and DEPT spectrum s...

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Abstract

The invention relates to the fields of extraction and separation of traditional Chinese medicines, in particular to a new compound which is extracted, separated out and identified from a medicine-parslane herb, and an extraction and separation method and application of the new compound; the invention in particular provides a peroxy bond-containing compound Oleracone I in the parslane herb as wellas an extraction and separation method and application of the compound. The extraction and separation method of the new compound sequentially adopts water decoction extraction, silica gel column chromatography, polyamide column chromatography, an ODS medium pressure column and Sephadex LH-20, thus successfully extracting and separating the new peroxy bond-containing compound. The structure of thecompound is identified as the new peroxy bond-containing compound by means of mass spectrometry, carbon spectroscopy, hydrogen spectroscopy and two-dimensional magnetic resonance ectroscopy analysis.The new compound has anti-tumor and anti-inflammatory effects, and the new compound and salts or derivatives thereof can be used as primers for synthesizing other compounds, and also can be used as raw materials for new medicine development and pharmacological activity research, thus being used for the preparation of anti-tumor and anti-inflammatory medicines.

Description

Technical field [0001] The present invention relates to the field of extraction and separation of traditional Chinese medicines, and in particular to new compounds extracted, separated and identified from Portulaca oleracea medicinal materials and methods for their extraction and separation, specifically Oleracone I, a peroxy bond-containing compound in Portulaca oleracea and its extraction Separation methods and applications. Background technique [0002] purslane( Portulaca oleracea L.), also known as horse amaranth, longevity vegetable, ant vegetable, is an annual herbaceous plant of the purslane family. Purslane is widely distributed and rich in resources. It is one of 78 wild plants with the same medicine and food as specified by the Ministry of Health. Purslane is included in the 2015 edition of "The Pharmacopoeia of the People's Republic of China". It has the effects of clearing away heat and detoxifying, cooling blood to stop bleeding, and stopping dysentery. It is used...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D323/00A61P35/00A61P29/00
CPCA61P29/00A61P35/00C07D323/00
Inventor 英哲铭英锡相马懿飞赵程程郭胜男
Owner LIAONING UNIV OF TRADITIONAL CHINESE MEDICINE
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