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Honeysuckle flower and radix scutellariae solution preparation for inhalation and preparing method thereof

A preparation and solution technology, applied in the field of preparation, can solve problems such as easy explosion, lack of suitable dosage form, failure, etc., and achieve the effects of high bioavailability, low dosage and good curative effect

Inactive Publication Date: 2019-10-11
BEIJING INCREASE INNOVATIVE DRUG RESEARCH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The preparation operation is troublesome; ③Aerosol has a certain internal pressure, and it is easy to explode when heated or impacted; ④The aerosol works by the vapor pressure of the propellant, which can be invalidated by the leakage of the propellant
[0005] However, the Yinqin preparations in the prior art are all oral dosage forms, and there is no clinical use of atomized inhalation preparations.
At the same time, traditional Chinese medicine has a good effect on cough, phlegm, dyspnea, dry mouth, hoarseness, sore throat, etc., but because there is no suitable dosage form, it can better exert its effect

Method used

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  • Honeysuckle flower and radix scutellariae solution preparation for inhalation and preparing method thereof
  • Honeysuckle flower and radix scutellariae solution preparation for inhalation and preparing method thereof
  • Honeysuckle flower and radix scutellariae solution preparation for inhalation and preparing method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Embodiment 1 inhales Yinqin solution

[0034]

[0035] (1) Take honeysuckle, Panax notoginseng, Houttuynia cordata and add 13 times the amount of water to soak for 30 minutes, decoct for 1 hour, add 10 times the amount of water for the second time, decoct for 1 hour, filter in stages, combine the filtrates, and concentrate to The relative density is 1.20~1.25 (measured at 70~80°C), let it cool to 40°C, slowly add ethanol to make the alcohol content reach 75%, stir well, let it stand for 12 hours, filter the supernatant, and recover the ethanol to nothing For mellow taste, add 3 to 4 times the amount of water, adjust the pH value to 7.0, stir well and heat to boiling, let stand for 48 hours, filter the supernatant, concentrate to a relative density of 1.10 to 1.15 (measured at 70 to 80°C) , let it cool to 40°C, add ethanol to make the alcohol content reach 85%, let it stand for 12 hours, filter the supernatant, recover the ethanol until it has no alcohol smell, add wa...

Embodiment 2

[0038] Embodiment 2 inhales Yinqin solution

[0039]

[0040] (1) Take honeysuckle, Panax notoginseng, Houttuynia cordata and add 13 times the amount of water to soak for 30 minutes, decoct for 1 hour, add 10 times the amount of water for the second time, decoct for 1 hour, filter in stages, combine the filtrates, and concentrate to The relative density is 1.20~1.25 (measured at 70~80°C), let it cool to 40°C, slowly add ethanol to make the alcohol content reach 75%, stir well, let it stand for 12 hours, filter the supernatant, and recover the ethanol to nothing For mellow taste, add 3 to 4 times the amount of water, adjust the pH value to 7.0, stir well and heat to boiling, let stand for 48 hours, filter the supernatant, concentrate to a relative density of 1.10 to 1.15 (measured at 70 to 80°C) , let it cool to 40°C, add ethanol to make the alcohol content reach 85%, let it stand for 12 hours, filter the supernatant, recover the ethanol until it has no alcohol smell, add wa...

Embodiment 3

[0043] Embodiment 3 inhales Yinqin solution

[0044]

[0045] (1) Take honeysuckle, Panax notoginseng, Houttuynia cordata and add 13 times the amount of water to soak for 30 minutes, decoct for 1 hour, add 10 times the amount of water for the second time, decoct for 1 hour, filter in stages, combine the filtrates, and concentrate to The relative density is 1.20~1.25 (measured at 70~80°C), let it cool to 40°C, slowly add ethanol to make the alcohol content reach 75%, stir well, let it stand for 12 hours, filter the supernatant, and recover the ethanol to nothing For mellow taste, add 3 to 4 times the amount of water, adjust the pH value to 7.0, stir well and heat to boiling, let stand for 48 hours, filter the supernatant, concentrate to a relative density of 1.10 to 1.15 (measured at 70 to 80°C) , let it cool to 40°C, add ethanol to make the alcohol content reach 85%, let it stand for 12 hours, filter the supernatant, recover the ethanol until it has no alcohol smell, add wa...

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PUM

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Abstract

The invention belongs to the field of the pharmaceutics technology, and particularly relates to a honeysuckle flower and radix scutellariae solution preparation for inhalation and a preparing method thereof. The honeysuckle flower and radix scutellariae solution preparation for inhalation comprises a first extract, a second extract, an auxiliary and a solvent. The first extract is prepared by extracting honeysuckle flower, leaves of panax notoginseng and houttuynia cordata, and the second extract is prepared by extracting radix scutellariae. The honeysuckle flower and radix scutellariae solution preparation for inhalation is safe, effective, high in bioavailability, small in use dosage, rapid in effect, good in treatment effect and free of other toxic and side effects; the preparation is given to a patient through atomized inhalation, the medicine is directly transmitted to a respiratory tract, absorption is rapid, and acting is rapid; the first-pass effect and gastrointestinal tract degradation can be avoided, the medicine concentration of a focus part is increased, the dosage of administration is reduced, the distribution of the medicine in other tissue is reduced, and side effects of the medicine are reduced.

Description

technical field [0001] The invention belongs to the field of pharmacy, and in particular relates to a silver bain solution preparation for inhalation and a preparation method thereof. Background technique [0002] The "Yinqin" prescription is composed of four traditional Chinese medicines: honeysuckle, scutellaria, notoginseng, and houttuynia cordata, which have the effects of clearing away heat and detoxification, and clearing away wind-heat. Honeysuckle in this prescription is cold in nature and sweet in taste, and has the effect of relieving heat and wind toxin; Scutellaria baicalensis is cold in nature and bitter in taste, which helps honeysuckle to play the role of relieving heat, wind and toxin, pouring fire and poison to reduce heat and phlegm; Houttuynia cordata is cool in nature, It has a bitter taste and a fishy smell, and it is specially used in the upper burner to resolve the wind-heat toxins in the upper body, and to reduce heat and phlegm, and to help the upper...

Claims

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Application Information

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IPC IPC(8): A61K36/78A61K9/72A61K9/08A61P29/00A61P31/00A61P11/00A61P11/04A61P11/14
CPCA61K9/0078A61K9/08A61K36/258A61K36/355A61K36/539A61K36/78A61K47/02A61K2236/331A61K2236/39A61K2236/53A61K2300/00
Inventor 张保献胡杰王志华
Owner BEIJING INCREASE INNOVATIVE DRUG RESEARCH CO LTD
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