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Dry eye symptom moisturizing spray and preparation method thereof

A moisturizing spray and dry eye technology, applied in the field of dry eye moisturizing spray and preparation thereof, can solve problems such as poor patient compliance, and achieve the effects of relieving discomfort symptoms, scientific prescription ratio, and easy popularization and application.

Active Publication Date: 2019-10-15
WENZHOU MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] Patent CN1456167A provides an artificial tear containing phospholipids, and patent CN1651090A provides an ocular drug delivery system containing trehalose and hyaluronic acid. The above treatment strategies are all effective by dripping into the patient's eyes, but in actual operation many The patient has obvious discomfort in the process of adding eye drops and artificial tears, and the patient's compliance is poor
In addition, many ocular medications currently available for dry eye lack the effectiveness of simultaneously keeping the eye moist while treating the ocular damage caused by dry eye

Method used

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  • Dry eye symptom moisturizing spray and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] A preparation method of a dry eye moisturizing spray, which comprises hyaluronic acid, aloe extract, allantoin, sodium chloride, and phosphate buffer.

[0046] To prepare 100g of the spray, weigh the components according to the following weight:

[0047] Hyaluronic acid: 0.01g

[0048] Aloe extract: 0.2g

[0049] Allantoin: 0.25g

[0050] Sodium chloride: 0.9g

[0051] Add pure water to 100g,

[0052] And use an appropriate amount of phosphate buffer to adjust the pH to 7.0~7.5.

[0053] The preparation process is as follows:

[0054] A. Pre-sterilize all containers used to prepare moisturizing sprays,

[0055] B. Weigh and mix the above raw materials,

[0056] C. Add ultrapure water to a total mass of 100g, use phosphate buffer to adjust the pH to 7.0~7.5, and fully stir to dissolve under normal temperature and pressure.

Embodiment 2

[0058] A dry eye moisturizing spray, which comprises dextran 70, dipotassium glycyrrhizinate, allantoin, sodium chloride, and phosphate buffer.

[0059] To prepare 100g of the spray, weigh the components according to the following weight:

[0060] Dextran 70: 0.03g

[0061] Dipotassium Glycyrrhizinate: 0.3g

[0062] Allantoin: 0.2g

[0063] Sodium chloride: 0.7 parts

[0064] Add pure water to 100g, and use an appropriate amount of phosphate buffer to adjust the pH to 7.0~7.5.

[0065] The preparation process is as follows:

[0066] A. Pre-sterilize all containers used to prepare moisturizing sprays,

[0067] B. Weigh and mix the above raw materials,

[0068] C. Add ultrapure water to a total mass of 100g, use phosphate buffer to adjust the pH to 7.0~7.5, and fully stir to dissolve under normal temperature and pressure.

Embodiment 3

[0070] A dry eye moisturizing spray, which includes hyaluronic acid, dipotassium glycyrrhizinate, allantoin, sodium chloride, potassium chloride, calcium chloride, and phosphate buffer.

[0071] To prepare 100g of the spray, weigh the components according to the following weight:

[0072] Hyaluronic acid: 0.08g

[0073] Dipotassium Glycyrrhizinate: 0.1g

[0074] Allantoin: 0.3g

[0075] Sodium chloride: 0.6g

[0076] Potassium chloride: 0.02g

[0077] Calcium chloride: 0.03g

[0078] Add pure water to 100g, and use an appropriate amount of phosphate buffer to adjust the pH to 7.0~7.5.

[0079] The preparation process is as follows:

[0080] A. Pre-sterilize all containers used to prepare moisturizing sprays,

[0081] B. Weigh and mix the above raw materials,

[0082] C. Add ultrapure water to a total mass of 100g, use phosphate buffer to adjust the pH to 7.0~7.5, and fully stir to dissolve under normal temperature and pressure.

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Abstract

The present invention provides a dry eye symptom moisturizing spray. The moisturizing spray mainly comprises a water-supplementing and moisturizing ingredient, an inflammation inhibitor, an ulcer repairing component, an osmotic adjusting agent and a pH buffering agent. Every 100 parts by weight of the moisturizing spray comprises the following components in parts by weight: 0.01 part-0.1 part of the water-supplementing and moisturizing ingredient, 0.1 part-0.3 part of the inflammation inhibitor, 0.15 part-0.3 part of the ulcer repairing component, 0.6 part-0.9 part of the osmotic adjusting agent and the balance ultrapure water, and the pH buffering agent is used to adjust pH value into 7.0-7.5. The present invention also provides a preparation method of the moisturizing spray. The moisturizing spray is specially used for relieving and treating related symptoms of dry eye syndromes, a special atomized moisturizing device generates micron-sized atomized droplets to warm and moist eyeballparts, wherein the water-supplementing and moisturizing component can maintain moisture for a long time and relieve the dry eye syndromes of eyeballs, and the dry eye symptom moisturizing spray is safe and non-toxic in ingredients, low in irritation and relatively high in user compliance.

Description

Technical field [0001] The invention relates to the field of eye health care, in particular to a dry eye syndrome moisturizing spray and a preparation method thereof. Background technique [0002] Dry eye syndrome is a general term for a variety of diseases that are caused by a variety of reasons to decrease the stability of the tear film, accompanied by ocular discomfort and / or ocular surface tissue lesions. The main symptoms of dry eye include dry eyes and fatigue, strong foreign body sensation in the eyes, pain and burning sensation, fear of wind, photophobia, and sensitivity to external stimuli. In more serious cases, the eyes will be red and swollen, congested, keratinized, and corneal epithelium broken. Filaments are attached to the skin. This damage can cause keratoconjunctival lesions over time and affect vision. [0003] In general, the treatment strategies for dry eye are: [0004] 1. Elimination of incentives: Long-term use of computers should be avoided, and less exposu...

Claims

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Application Information

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IPC IPC(8): A61K36/886A61K36/896A61K9/12A61K47/02A61P27/02A61K31/4166A61K31/704A61K31/721A61K31/728A61K33/14
CPCA61K9/0048A61K9/12A61K31/4166A61K31/704A61K31/721A61K31/728A61K33/14A61K36/886A61K36/896A61K47/02A61P27/02A61K2300/00
Inventor 周铁丽方人驰曹建明陈涛张秀彩
Owner WENZHOU MEDICAL UNIV
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