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Nano-vesicle preparation coating vitamin D and vitamin K and application thereof

A technology of nano-vesicles and vitamins, which is applied in the field of drugs for the treatment of osteoarthritis and nano-vesicle preparations coated with vitamin D and vitamin K. It can solve the problems of difficulty entering the blood circulation and low bioavailability, and achieve clinical improvement. Curative effect, simple preparation method, effect of improving drug efficacy

Inactive Publication Date: 2019-10-18
澳汀斯(广州)生物医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The compound preparations of vitamin D and vitamin K are mainly made into ordinary capsules and tablets. However, since both vitamin D and vitamin K are fat-soluble, it is difficult for them to enter the blood circulation, so their bioavailability is low.

Method used

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  • Nano-vesicle preparation coating vitamin D and vitamin K and application thereof
  • Nano-vesicle preparation coating vitamin D and vitamin K and application thereof
  • Nano-vesicle preparation coating vitamin D and vitamin K and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038]In a 250 ml flask, lecithin liposomes (containing 1 g PC), 7.5 mg vitamin K and 3 mg vitamin D were dissolved in 5 ml chloroform, the solvent was removed by rotary evaporation, and acetic acid-sodium acetate at pH=6 was added 99 ml of buffer solution was passed through high-purity nitrogen gas for 20 minutes, and ultrasonically treated with a phacoemulsifier with a frequency of 20KHz and a power of 300W for 10 minutes to obtain light yellow stable vesicle fluid.

Embodiment 2

[0040] In a 250 ml flask, dissolve lecithin liposomes (containing 1 g PC), 50 mg vitamin E, 7.5 mg vitamin K, and 3 mg vitamin D in 5 ml chloroform, remove the solvent by rotary evaporation, and add pH=6 99 ml of acetic acid-sodium acetate buffer solution was passed through high-purity nitrogen for 20 minutes, and ultrasonically treated with a phacoemulsifier with a frequency of 20 KHz and a power of 300 W for 10 minutes to obtain light yellow stable vesicle fluid.

Embodiment 3

[0042] In a 250 ml flask, dissolve lecithin liposomes (containing 1 g PC), 50 mg vitamin E, 7.5 mg vitamin K, and 3 mg vitamin D in 5 ml chloroform, remove the solvent by rotary evaporation, and add pH=8 99 milliliters of tris buffer solution was passed through high-purity nitrogen for 20 minutes, and ultrasonically treated with a phacoemulsifier with a frequency of 20KHz and a power of 300W for 10 minutes to obtain light yellow stable vesicle fluid.

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Abstract

The invention provides a nano-vesicle preparation coating vitamin D and vitamin K and application thereof. The nano-vesicle preparation is prepared from, by mass, 1-3 parts of the vitamin D, 3-7 partsof the vitamin K and 30-100 parts of a vesicle auxiliary material. The preparation process of the nano-vesicle preparation comprises the steps that the vesicle auxiliary material, the vitamin D and the vitamin K are dissolved in a solvent and then uniformly dispersed to obtain a vesicle solution. The nano-vesicle preparation coating the vitamin D and vitamin K and the application thereof have theadvantages that the nano-vesicle preparation is prepared by adopting a vesicle coating technology to coat the vitamin D and the vitamin K, it can be achieved that the vitamin D and the vitamin K aredirectly delivered into the blood, and compared with a traditional oral preparation, the pharmaceutical effect can be improved by at least several times; a new method is provided for osteoarthritis research, and an innovative means is provided for treating and preventing osteoarthritis.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical preparations, and in particular relates to a nanovesicle preparation coated with vitamin D and vitamin K and its application; in particular, it relates to a nanovesicle preparation coated with vitamin D and vitamin K and the preparation of the nanovesicle preparation Use of a drug for the treatment of osteoarthritis. Background technique [0002] Osteoarthritis is the most common form of arthritis, most commonly affecting the knee joint. It can cause pain and disability, seriously affecting people's ability to work and quality of life. According to the World Health Organization, the global prevalence of symptomatic osteoarthritis in people over 60 years old is 9.6% for men and 18% for women. In 2010, there were approximately 251 million knee osteoarthritis patients worldwide, accounting for 3.6% of the total population. Due to the increase in the average human life expectancy and the inc...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/127A61K47/24A61K31/59A61K31/122A61P19/02A61P29/00
CPCA61K47/24A61P19/02A61P29/00A61K9/127A61K31/122A61K31/59A61K2300/00
Inventor 丁长海杨卫东阮光峰韩卫雨朱兆华
Owner 澳汀斯(广州)生物医药科技有限公司
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