Method and device for sleep deprivation, computer equipment and storage medium

Abstract

The embodiment of the invention discloses a method and device for sleep deprivation, computer equipment and a storage medium. The method comprises the following steps of introducing set genes to set cells in a target animal body in advance, wherein the set cells are neuron cells participating in a waking-sleeping behavior adjusting and controlling mechanism, and the set genes comprise excited typeprotein genes and inhibitable type protein genes; acquiring a physiological signal of a target animal; and when the situation that the physiological signal is a sleep signal is determined, using a set light adjusting and controlling signal to perform light adjusting and controlling on the set cells, wherein the set light adjusting and controlling signal is a light beam having a set wave length, and is used for activating the set genes. Through the adoption of the method disclosed by the embodiment of the invention, a conventional sleep deprivation method is optimized, the reliability of a sleep deprivation test is improved, and the accuracy of test data is guaranteed.

Description

technical field [0001] Embodiments of the present invention relate to the technical field of sleep deprivation, and in particular, to a sleep deprivation method, device, computer equipment, and storage medium. Background technique [0002] Sleep is a spontaneous and reversible resting state of the brain that occurs periodically in higher vertebrates. It is a decrease in the body's response to external sensory stimuli and a short interruption of consciousness. Studies have shown that sleep is closely related to learning and memory, regulation of the biological clock, metabolism of organisms, immunity, and secretion of hormones. Sleep disorders can affect abnormal changes in brain thinking, memory, emotion, immunity, etc., and are closely related to the occurrence of mental diseases and may also lead to neurometabolic, neuroimmune, and neuroendocrine-related diseases. [0003] At present, in order to study the influence of sleep on organisms, researchers usually deprive exper...

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Problems solved by technology

[0004] The forced exercise method is to force the experimental animals to move continuously through a power device (such as a rotating cage), so as to achieve the purpose of sleep deprivation, but long-term non-stop exercise will cause exercise stress and physical fatigue, which will become factors that interfere with sleep deprivation. Due to the angle defect between the food cage and the rotating cage, sometimes the head of the experimental animal gets stuck between the food cage and the rotating cage, causing injury or death of the experimental animal; the physical stimulation method is that the experimental animal is subjected to physical stimulation to keep awake, and needs to be studied. Personnel perform the operation of applying physical stimulation, but this method can easily lead to sleep deprivation of researchers, resulting in large errors, so it is more suitable for short-term sleep deprivation experiments, and physical stimulation may cause damage to experimental animals, making it impossible to study the natural state The sleep state of the animals, and the electrical stimulation may cause changes in the chemical substances in the brain, resulting in changes in the research baseline, resulting in the inability to accurately obtain the state data of the tested animals; drug stimulation deprivation is to regularly inject some central nervous system stimulants to the experimental animals It can also cause partial or total sleep deprivation, but there are individual differences in experimental animals, and the effect and degree of sleep deprivation are not easy to grasp, so it is often used in pharmacological experiments to study special drugs; when the water platform method uses experimental animals to enter REM sleep, The reduction of muscle tone in the whole body causes rhythmic bowing of the head, and the head touches the water surface to wake up, so as to achieve the purpose of rapid eye movement sleep deprivation. There are many stress factors such as environmental isolation, activity restriction, physical fatigue, and repeated falling into the water, which interfere reliability of results

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