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Preparation method and application of chiral helical polyaniline@MOF nano composite material

A nanocomposite material, polyaniline technology, which is applied in the direction of material analysis, material analysis, material electrochemical variables, etc. by electromagnetic means, can solve the problems of small number of chiral MOFs, complex synthesis of chiral ligands, and slow research progress. , to achieve the effect of easy operation, simple preparation method, simple and controllable process

Active Publication Date: 2019-10-22
UNIV OF JINAN
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, compared with a large number of reported achiral MOFs materials, the number of chiral MOFs is small, and the research progress is slow.
An important reason is that the synthesis of chiral ligands is complex, costly, and low in yield. Therefore, it is of great significance to synthesize chiral MOFs composites from achiral MOFs raw materials.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Example 1 A preparation method of chiral helical polyaniline@MOF nanocomposite

[0033] (1) Preparation of helical polyaniline supported Co 2+ Intermediate

[0034] Dissolve 1 mmol cobalt nitrate, 40 µL aniline and 6 mL isopropanol in 8 mL dilute sulfuric acid solution with a concentration of 0.01-1.0 mmol / L, and stir for 5-10 min to obtain a clear mixed solution of aniline-cobalt nitrate;

[0035] Dissolve 0.8 mmol of ammonium persulfate in 2 mL of water to obtain a clear ammonium persulfate solution;

[0036] Add the ammonium persulfate solution to the mixed solution of aniline-cobalt nitrate, mix well, and immediately place the reaction solution at a constant temperature of 20°C. After reacting overnight, filter it with suction and dry it at room temperature to obtain a helical polyaniline-loaded Co 2+ intermediates;

[0037] (2) Preparation of chiral helical polyaniline@MOF nanocomposites

[0038] 0.5 g helical polyaniline was loaded with Co 2+ The intermediate...

Embodiment 2

[0041] Example 2 Preparation method of a chiral helical polyaniline@MOF nanocomposite

[0042] (1) Preparation of helical polyaniline supported Co 2+ Intermediate

[0043] Dissolve 1.5 mmol cobalt nitrate, 50 µL aniline and 7 mL isopropanol in 10 mL dilute hydrochloric acid with a concentration of 0.05-2 mmol / L, and stir for 8 min to obtain a clear mixed solution of aniline-cobalt nitrate;

[0044] Dissolve 0.9 mmol of ammonium persulfate in 2.5 mL of water to obtain a clear ammonium persulfate solution;

[0045] Add the ammonium persulfate solution to the mixed solution of aniline-cobalt nitrate, mix well, and immediately place the reaction solution at a constant temperature of 20°C. After reacting overnight, filter it with suction and dry it at room temperature to obtain a helical polyaniline-loaded Co 2+ intermediates;

[0046] (2) Preparation of chiral helical polyaniline@MOF nanocomposites

[0047] 0.65 g helical polyaniline was loaded with Co 2+ The intermediate was...

Embodiment 3

[0050] Example 3 Preparation method of a chiral helical polyaniline@MOF nanocomposite

[0051] (1) Preparation of helical polyaniline supported Co 2+ Intermediate

[0052] Dissolve 2 mmol cobalt nitrate, 60 µL aniline and 8 mL isopropanol in 12 mL dilute nitric acid with a concentration of 1.0 mmol / L, and stir for 10 min to obtain a clear mixed solution of aniline-cobalt nitrate;

[0053] Dissolve 01.0 mmol of ammonium persulfate in 3 mL of water to obtain a clear ammonium persulfate solution;

[0054] Add the ammonium persulfate solution to the mixed solution of aniline-cobalt nitrate, mix well, and immediately place the reaction solution at a constant temperature of 20°C. After reacting overnight, filter it with suction and dry it at room temperature to obtain a helical polyaniline-loaded Co 2+ intermediates;

[0055] (2) Preparation of chiral helical polyaniline@MOF nanocomposites

[0056] 0.8 g helical polyaniline was loaded with Co 2+ The intermediate was ultrasonica...

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Abstract

The invention discloses a preparation method of a chiral helical polyaniline@MOF nano composite material and the application of the composite material to the detection of chiral drug enantiomers and belongs to the technical field of nano composite material and chiral electrochemical sensing detection. The preparation method comprises the following main steps that: cobalt nitrate is mixed with a precursor solution for preparing helical polyaniline; the cobalt nitrate reacts with the precursor solution at a constant temperature of 20 DEG G overnight; an obtained product is added into a 2-methylimidazole solution; a self-assembly reaction is carried out under a normal temperature condition, so that the chiral helical polyaniline@MOF nano composite material can be prepared. A chiral sensor constructed by adopting the composite material is used for sensitively detecting the content of L-tyrosine and D-tyrosine enantiomers. The chiral sensor can be prepared by a simple method; the chiral sensor is easy to operate; and the chiral detection effect of the chiral sensor is remarkable.

Description

technical field [0001] The invention relates to a chiral helical polyaniline@MOF nanocomposite material and its preparation method and application, belonging to the technical fields of nanomaterials, metal organic framework nanomaterials and chiral electrochemistry. Background technique [0002] Chirality exists widely in nature. For example, amino acids in human body are all in L configuration, and glucose in plants in nature is in D configuration. Many pharmaceuticals, nutraceuticals, and pesticides have a set of enantiomers that are mirror images, but these enantiomers often exhibit different biological activities and pharmacological responses. The composition, function and safety of drugs, nutraceuticals and pesticides are related to the content of amino acids in a certain configuration. Therefore, how to identify chiral substances has always been one of the difficult problems that must be solved in the production and development of many chiral products. [0003] Chira...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N27/30G01N27/48
CPCG01N27/308G01N27/48
Inventor 刘昭轩匡轩刘彪
Owner UNIV OF JINAN
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