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Rubidium salt hemostatic sponge and application thereof

A technology of hemostatic sponge and rubidium salt, which is applied in the field of medical materials, can solve the problem of not outstanding hemostatic effect of hemostatic materials, and achieve the effects of rapid hemostatic tissue healing, convenient use, good biocompatibility and absorbable degradability

Pending Publication Date: 2019-10-25
易杨华
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Moreover, the hemostatic material composed of collagen and chitosan does not have a prominent hemostatic effect, so it is not suitable for sudden large trauma bleeding

Method used

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  • Rubidium salt hemostatic sponge and application thereof
  • Rubidium salt hemostatic sponge and application thereof
  • Rubidium salt hemostatic sponge and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Embodiment 1. prepare rubidium salt hemostatic sponge

[0026] To make rubidium salt hemostatic sponge, the clean environment is required to meet the national GMP requirements of 1 million grades, and the local ultra-clean workbench must reach 100,000 grades. The specific production method is as follows:

[0027] 1. Put 10 grams of fish skin collagen in a stainless steel container, add 600ml of 0.5M acetic acid solution, and use a homogenizer to homogenize at a high speed, 10,000 rpm for 10-20 minutes.

[0028] 2. Add 0.2 grams of rubidium tetrafluoroborate and 2 grams of glycerol, homogenate for more than 10 minutes, until the solution is completely uniform and translucent colloid.

[0029] 3. Lay out the plate and freeze-dry to form a sponge.

[0030] 4. Cut into slices, pack in medical polyethylene packing box, and sterilize by γ-ray irradiation.

[0031] Preparation of fish skin collagen: fish skin is degreased, decolorized and decellularized by alkali and oxidan...

Embodiment 2

[0032] Embodiment 2. prepare rubidium salt hemostatic sponge

[0033] 1. Put 100 grams of fish skin collagen in a stainless steel container, add 6000ml of 0.5M acetic acid solution, and use a homogenizer to homogenize at a high speed, 10000 rpm, 10-20 minutes.

[0034] 2. Add 2 grams of rubidium tetrafluoroborate and 40 grams of glycerol, homogenate for more than 10 minutes, until the solution is completely uniform and translucent colloid.

[0035] 3. Lay out the plate and freeze-dry to form a sponge.

[0036] 4. Cut into slices, pack in medical polyethylene packing box, and sterilize by γ-ray irradiation.

[0037] The appearance of the rubidium salt hemostatic sponge is white, spongy, and elastic. The proper ratio of rubidium salt, fish collagen and plasticizer is the key to realize the effect of the present invention, and an inappropriate ratio cannot prepare a hemostatic material with good tissue adhesion and rapid hemostasis.

Embodiment 3

[0038] Example 3. Rubidium salt in vitro blood coagulation test

[0039] 1. Materials and Methods

[0040] 1.1 Experimental materials:

[0041] 1.1.1 Experimental animals: rabbits

[0042] 1.1.2 Experimental equipment: syringe, test tube, arterial clamp, arterial cannula, constant temperature water bath, stopwatch.

[0043] 1.1.3 Experimental drugs: rubidium tetrafluoroborate, rubidium nitrate, rubidium carbonate, rubidium sulfate.

[0044] 1.2 Experimental method

[0045] 1.2.1 Anesthetize rabbits by injecting 200g / L ethyl carbamate (urethane) into the ear margin vein at a dose of 5ml / kg body weight, and fix the rabbits supine on the rabbit operating table.

[0046] 1.2.2 After cutting the skin of the neck (remove the rabbit hair on the neck first), separate the external jugular vein, and collect 10ml of blood.

[0047] 1.2.3 Separate the common artery on one side, ligate the head with a thread, and clamp the arterial clip on the centripetal end. Use ophthalmic scissors...

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Abstract

The invention provides a rubidium salt hemostatic sponge and application thereof. The rubidium salt hemostatic sponge comprises rubidium salt, collagen and a plasticizer, and the mass ratio of the rubidium salt, the collagen and the plasticizer is (1-8): 100: (1-5). The rubidium salt hemostatic sponge provided by the invention can be used as a trauma emergency hemostatic material, has good tissueadhesion, can rapidly stop bleeding and promote tissue healing, has no immunogenicity, sterility, no toxicity and no stimulation, has good biocompatibility and absorbability and degradability, and hasno side effect on the body. Meanwhile, the hemostatic wound protection bandage is simple to operate and convenient to use, is suitable for hemostasis of gunshot wounds and explosive wounds of all parts of the chest and abdomen and the whole body, and can also be conveniently used for hemostasis of special parts, such as neck, armpit and groin, of limb joints where a tourniquet is difficult to use.

Description

technical field [0001] The invention relates to the technical field of medical materials, in particular to a rubidium salt rapid hemostasis material and its application. Background technique [0002] At present, trauma rescue has always followed the traditional simple tourniquet, triangular towel and other hemostatic materials. Tourniquets have achieved remarkable results in controlling extremity bleeding, reducing the proportion of massive extremity bleeding in the US military in Afghanistan and Iraq to 2% to 7%. However, non-compressible hemorrhage caused by battle injuries in the trunk and junctional parts, as well as in the thorax and abdomen, has become a major challenge. The U.S. military currently uses CELOX hemostatic dressing made of chitosan, which is used as a hemostatic material for massive bleeding caused by vascular trauma on the battlefields of Afghanistan and Iraq, and has a good hemostatic effect. An American company hopes to use biodegradable materials to...

Claims

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Application Information

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IPC IPC(8): A61L24/10A61L24/02A61L24/00A61L15/18A61L15/32A61L15/42A61L15/62
CPCA61L15/18A61L15/325A61L15/42A61L15/425A61L15/62A61L24/001A61L24/0036A61L24/0042A61L24/02A61L24/102A61L2400/04
Inventor 易杨华
Owner 易杨华
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