Method for extracting and separating lignans from Artemisia persicae

A technology for lignans and compounds, applied in chemical instruments and methods, organic chemistry, sugar derivatives, etc., can solve problems such as inability to extract lignans, and achieve the effects of low cost, large quantity and high purity

Inactive Publication Date: 2020-09-29
JILIN NORMAL UNIV
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Problems solved by technology

[0004] The purpose of the present invention is to provide a method for extracting and separating lignans from Artemisia persicae, in order to solve the existing technical problem that lignans cannot be extracted from Artemisia persicae

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  • Method for extracting and separating lignans from Artemisia persicae

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Embodiment Construction

[0019] In order to enable those skilled in the art to better understand the purpose, technical solutions and advantages of the present invention, the present invention will be further described below in conjunction with specific examples, but the given examples are not intended to limit the present invention.

[0020] Instruments and reagents

[0021] INOVA-500MHz-FT nuclear magnetic resonance instrument (U.S. Varian company), TMS is an internal standard; Agilent 6320 mass spectrometer (U.S. Agilent company); Dionex Ultimate 3000 semi-preparative high-performance liquid chromatograph (U.S. Dionex company). Silica gel for thin-layer chromatography and column chromatography (Qingdao Ocean Chemical Factory), octadecylsilane bonded silica gel (ODS) column chromatography material (YMC Company, Japan); semi-preparative chromatography column Eclipse XDB-C18 (250mm×9.4mm, 5μm ) (Agilent Corporation, USA). The chromatographic methanol and acetonitrile used in HPLC were products of Fis...

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Abstract

The invention relates to a method for extracting and separating a lignans compound from artemisia sacrorum. The lignans compound comprises (+)-epipinoresinol, lariciresinol-4'-O-beta-D-glucoside and lariciresinol-4-O-beta-D-glucoside. The extraction and separation method comprises carrying out separating purification on an ethyl acetate extraction part of a 95% ethanol extract of artemisia sacrorum by adopting a plurality of chromatographic methods such as silica gel chromatography, ODS open column chromatography, semi-preparative liquid chromatography and the like, and the three compounds areobtained by separation for the first time. The extraction method is simple, extraction efficiency is high, the amount of the extracted compounds is large, and a foundation is laid for physical research of lignans compounds. Meanwhile, chemical components of artemisia sacrorum medicinal materials are enriched, and the medicinal material basis of the artemisia sacrorum medicinal materials is further clarified.

Description

technical field [0001] The invention relates to the field of compound extraction, in particular to a method for extracting and separating lignan compounds from Artemisia permanensis. Background technique [0002] Lignans have a wide range of biological activities, such as anti-tumor, anti-oxidation, antihypertensive, sedative and hepatoprotective, and can be used as plant germination inhibitors, growth inhibitors and fungicides; therefore, how to effectively use The extraction of lignans from medicinal plants to obtain products with higher purity plays an important role in the in-depth study of lignans. [0003] Artemisia sacrorum Ledeb. is a semi-shrub herbaceous plant of the genus Artemisia in the Compositae family. It grows in hillsides, roadsides, shrublands and forest grasslands in low- and middle-altitude areas. Its dry aboveground parts It is a commonly used medicinal material of the Korean nationality, which is recorded in the 1977 edition of "Jilin Provincial Drug ...

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07D493/04C07H1/08C07H15/26
CPCC07D493/04C07H1/08C07H15/26
Inventor 孙艳涛赵磊冯静东于国强赵国升
Owner JILIN NORMAL UNIV
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