Circular dichroism enhancement device and detection method based on super-chiral light fieldcircular dichroism enhancement device and detection method based on super-chiral light field

Abstract

The invention relates to a circular dichroism enhancement device and a circular dichroism enhancement detection method based on a super-chiral light field. The circular dichroism enhancement device isformed by superposing a silicon dioxide substrate, a gold thin film, a magnesium fluoride nano-cylindrical array and a gold nano-cylindrical array from bottom to top. Vertically incident circularly-polarized light is going to the efficiently coupled into an optical resonant cavity formed by the gold thin film, the magnesium fluoride nano-cylindrical array and the gold nano-cylindrical array, andgenerates a super-chiral light field with the optical chiral density higher than that of ordinary circular polarization. When chiral molecules interact with the super-chiral light field and a resonance peak of the molecules is matched with the resonance wavelength of the resonant cavity, the circular dichroism of the chiral molecules can be greatly improved. In addition, through reducing a gap between the nano-cylindrical arrays, red shift of the resonance peak of the resonant cavity can be caused, thereby being conductive to further enhancing the optical chiral density of the light field in the resonant cavity and circular dichroism signals of the chiral molecules. The circular dichroism enhancement device and the circular dichroism enhancement detection method have the advantages of great circular dichroism signal intensity, high expandability and the like.

Description

technical field [0001] The invention relates to an optical device, in particular to a circular dichroism enhancement device and detection method based on a superchiral light field. Background technique [0002] Chirality refers to the structural property that an object and its mirror image cannot coincide through symmetry operations such as translation and rotation. Groups of structures with such properties are called enantiomers, and they usually have different configurations. Chirality exists in various microstructures, for example, all proteins, nucleic acids, enzymes, nucleosides and a large number of alkaloids are chiral compounds, while DNA double helix, quartz and cholesteric liquid crystals also exist chiral structure. Although chiral molecules with different configurations have the same chemical structure, they often exhibit different chemical properties. If the original chirality of biomolecules changes, it may become inactive or produce cytotoxicity. The config...

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Problems solved by technology

[0005] The present invention is aimed at the traditional circular dichroism enhancement method relying on the three-dimensional metal micro-nano structure that is difficult to prepare or the planar metal micro-nano structure with limited enhancement effect, which greatly limits the application of

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