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A kind of preparation method of double-layer silk fibroin film with antibacterial function

A silk film, double-layer technology, applied in the field of medical materials, to achieve the effect of promoting healing

Active Publication Date: 2022-04-01
ZHEJIANG SCI-TECH UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in the prior art, there is no report of compounding the above-mentioned substances as medical materials

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] 1) Take 50g of fresh aloe vera leaves, cut off the moldy part, rinse with distilled water continuously, and grind it into juice with a food grinder after washing. Then add ethanol and glacial acetic acid to the juice to make the solution acidic, then ultrasonically extract the solution, and finally vacuum filter the solution after ultrasonic to obtain the filtrate, wherein the ultrasonic power is 200W during ultrasonication, the ultrasonic time is 40min, and the ultrasonic temperature is 36 Spend. The ethanol concentration used is 75%, and the solid-liquid ratio of juice and ethanol is 1: 2;

[0021] 2) With the help of supercritical fluid extraction technology, using peppermint oil as a raw material, extract menthol at a pressure of 9.0 MPa and a temperature of 35 degrees;

[0022] 3) Mix 10 g of menthol obtained by extraction with 20 g of aloe juice to obtain a solution;

[0023] 4) Soak the mulberry silk in the prepared degumming solution (sodium carbonate solution...

Embodiment 2

[0027] 1) Take 50g of fresh aloe vera leaves, after cutting off the mildew spots, rinse them continuously with distilled water, and grind them into juice with a food grinder after washing. Then add a certain amount of ethanol and glacial acetic acid to the juice to make the solution acidic, then perform ultrasonic extraction on the solution, and finally vacuum filter the solution after ultrasonic to obtain the filtrate, wherein the ultrasonic power is 200W during ultrasonic, and the ultrasonic time is 50min. Ultrasonic temperature 40 degrees. The used ethanol concentration is 75%, and the solid-liquid ratio of juice and ethanol is 1: 2.5;

[0028] 2) With the help of supercritical fluid extraction technology, using peppermint oil as a raw material, extract menthol at a pressure of 9.5 MPa and a temperature of 40 degrees;

[0029] 3) Mix 10 g of menthol obtained by extraction with 20 g of aloe juice to obtain a solution;

[0030] 4) Soak the mulberry silk in the prepared degu...

Embodiment 3

[0034] 1) Take 50g of fresh aloe vera leaves, after cutting off the mildew spots, rinse them continuously with distilled water, and grind them into juice with a food grinder after washing. Then add a certain amount of ethanol and glacial acetic acid to the juice to make the solution acidic, then perform ultrasonic extraction on the solution, and finally vacuum filter the solution after ultrasonic to obtain the filtrate, wherein the ultrasonic power is 200W during ultrasonic, and the ultrasonic time is 50min. The ultrasonic temperature is 35 degrees. The used ethanol concentration is 75%, and the solid-liquid ratio of juice and ethanol is 1: 2.6;

[0035] 2) With the help of supercritical fluid extraction technology, using peppermint oil as a raw material, extract menthol at a pressure of 9.0 MPa and a temperature of 35 degrees;

[0036] 3) Mix 10 g of menthol obtained by extraction with 20 g of aloe juice to obtain a solution;

[0037]4) Soak the mulberry silk in the prepare...

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PUM

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Abstract

The invention relates to the field of medical materials, and discloses a preparation method of a double-layer silk film with antibacterial function, comprising: 1) preparation of aloe juice; 2) preparation of menthol; 3) preparation of menthol-aloe mixture ; 4) Preparation of silk fibroin liquid; 5) Preparation of menthol-aloe silk fibroin base film; 6) Preparation of double-layer silk fibroin film. The double-layer silk fibroin film obtained by the present invention has an outer layer of silk fibroin base film containing nano-magnesium oxide, and an inner layer of silk fibroin base film containing menthol-aloe vera. The outer film can effectively prevent bacteria and avoid nano-oxidation Magnesium is potentially harmful in direct contact with human skin. The inner film contains natural antibacterial agents, which are non-toxic and harmless. In addition to the antibacterial effect, it also has the functions of promoting healing and moisturizing the skin.

Description

technical field [0001] The invention relates to the field of medical materials, in particular to a preparation method of a double-layer silk fibroin film with antibacterial function. Background technique [0002] Silk fibroin has good biocompatibility, degradability, and non-toxic and non-irritating properties to the body. It can be used as a wound covering material. However, since it does not have antibacterial properties, it is necessary to add antibacterial agents. Aloe vera, also known as slaves, is a miraculous plant that integrates medical treatment, beauty and health care. It is known as a "plant doctor". Among them, aloe vera contains aloin, which is an anthraquinone extract , has sun protection, antibacterial, anti-inflammatory and other effects, and is naturally environmentally friendly and safe. Menthol, an organic compound extracted from peppermint and peppermint essential oil, has cooling and anti-itch properties. Nano-magnesium oxide has attracted more and mo...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08J5/18C08L89/00C08K13/02C08K5/1545C08K5/05C08K3/22
CPCC08J5/18C08J2389/00C08K13/02C08K5/1545C08K5/05C08K2003/222C08K2201/011Y02P20/54
Inventor 王秉郑浩然朱诚翟雨洁胡智文万军民
Owner ZHEJIANG SCI-TECH UNIV