Application of Qingre Qushi Huoxue Decoction in the Preparation of Drugs for Inhibiting Esophageal Cancer Cells

Abstract

The invention relates to a prescription for clearing away heat, dispelling dampness and promoting blood circulation and its disassembled prescriptions in the preparation of drugs for inhibiting esophageal cancer cells, which can effectively solve the problem of preparing drugs for inhibiting esophageal cancer cells EC9706, ECa109, EC‑1 and TE‑1. The heat-clearing, damp-dispelling and blood-activating prescription is made of Mianxiu 9‑20g, white hair rattan 15‑30g, black bone rattan 9‑24g, and Xiawu 6‑15g. The wet formula is made of 9-20g of Mianzixie and 15-30g of white hair rattan, the blood-activating formula is made of 9-24g of black bone rattan, and 6-15g of Xia Wu. Huoxue recipes were soaked in ethanol with a volume concentration of 95% and soaked for 7 days. The amount of ethanol added was 5 times the weight of the medicine in each prescription, shaken once a day in the morning and evening, vacuum filtered, and the filtrate was dried at a constant temperature of 58°C to obtain ethanol extraction dry matter respectively. Store at ‑20°C. The invention has abundant raw materials, simple preparation method, easy production and preparation, opens up new uses of the prescription for clearing away heat, dispelling dampness and promoting blood circulation and its disassembled prescriptions, and improves the medicinal value and commercial value.

Description

technical field [0001] The invention relates to medicine, in particular to a prescription for clearing heat, dispelling dampness and promoting blood circulation and the application of its disassembled prescription in the preparation of medicines for inhibiting esophageal cancer cells. Background technique [0002] Esophageal cancer is a malignant tumor that originates in the esophagus, and its morbidity and mortality rank fifth among malignant tumors in the world. According to research statistics, the 5-year survival rate of esophageal cancer is only about 13%. my country is a country with a high incidence of esophageal cancer and one of the countries with the highest mortality rate from esophageal cancer in the world. Esophageal cancer is divided into esophageal squamous cell carcinoma and esophageal adenocarcinoma. In my country, esophageal squamous cell carcinoma is the main type. Smoking, drinking, eating pickled vegetables, eating too fast, psychological factors, and fa...

AI Technical Summary

Problems solved by technology

The purpose of this study is to study the inhibitory effect of some traditional Chinese medicines that are not commonly used in clinical practice on esophageal cancer cells, and to screen out Chinese medicines that have a strong inhibitory effect on esophageal cancer cells. The impact of biological behaviors such as migration and invasion, research on the effects of prescriptions on the expression of EGFR and PI3K proteins, and explore the relationship between esophageal cancer, traditional Chinese medicine prescriptions, and traditional Chinese medicines, expect to provide new prescriptions and references for the clinical treatment of esophageal cancer in traditional Chinese medicine, and more To further tap the great potential of traditional Chinese medicine in the treatment of esophageal cancer, but there has been no public report so far

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