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Drug-carrying small-caliber intravascular stent and preparation method thereof

A vascular stent and a small-caliber technology are applied in the field of drug-loaded small-caliber vascular stents and their preparation, which can solve problems such as weight loss and drug effectiveness limitation, and achieve the advantages of promoting cell proliferation and migration, good application prospect and simple preparation method. Effect

Inactive Publication Date: 2019-11-05
DONGHUA UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the drug effectiveness of RM is limited by the blood-brain barrier; moreover, systemic administration of high doses of RM can lead to certain side effects, such as reduced food intake and concomitant weight loss, etc.

Method used

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  • Drug-carrying small-caliber intravascular stent and preparation method thereof
  • Drug-carrying small-caliber intravascular stent and preparation method thereof
  • Drug-carrying small-caliber intravascular stent and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0031] 1. Dethinning Treatment and Characterization of Rat Abdominal Aorta

[0032] (1) After SD rats (8 weeks old) were given intraperitoneal anesthesia with 2% pentobarbital 40mg / kg (0.2ml / 100g), the thoracic aorta was completely removed to the level of the descending aorta above the bifurcation of the iliac artery, and placed Rinse repeatedly in sterile normal saline to remove blood clots in the aorta, and remove extravascular fat and connective tissue to obtain natural non-decellularized rat aorta (Native rataortas, NRA).

[0033] (2) Treat NRA in decellularized solution, which is: PBS solution containing 0.5% Triton-X100, 0.5% sodium deoxycholate (SD) and 0.5% sodium dodecylsulfonate (SDS) And PBS solution containing 20 μg / ml RNAse and 200 μg / ml DNAse. Finally, the decellularized aorta was washed and shaken in PBS solution containing 1× penicillin-streptomycin double antibody solution to obtain decellularized rat aorta (Decellularized rat aortas, DRA).

[0034] The bloo...

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Abstract

The invention relates to a drug-carrying small-caliber intravascular stent and a preparation method thereof. The stent is of a double-layer structure, wherein the outer layer is drug-carrying electrostatic spinning nanofibers, and the inner layer is an accellular blood vessel layer. According to the inner accellular blood vessel layer, while antigenicity is eliminated, a natural porous microstructure of an original blood vessel is reserved, a proper microenvironment can be provided, and thus cell proliferation and migration are promoted; and the external drug-carrying nanofiber layer can remarkably improve the lost mechanical strength of accellular blood vessels and has a local drug sustained release function, and meanwhile, the whole body side effects of drugs are limited to the minimum extent.

Description

technical field [0001] The invention belongs to the field of tissue engineering stents, in particular to a drug-loaded small-caliber vascular stent and a preparation method thereof. Background technique [0002] Small-bore artery disease, especially coronary artery occlusion, is associated with high morbidity and mortality worldwide. Coronary artery bypass grafting (CABG) and percutaneous coronary intervention (PCI) are routine therapeutic strategies for the treatment of coronary artery disease. Traditional saphenous vein grafts are prone to intimal hyperplasia after CABG, leading to atherosclerosis and occlusion of the grafts; meanwhile, in-stent restenosis and thrombosis after PCI are also the main reasons that affect the prognosis of interventional therapy. In the field of surgical treatment of coronary artery disease, renal artery stenosis, and other peripheral vascular diseases, there is always a significant need for small diameter (inner diameter <6 mm) vascular gr...

Claims

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Application Information

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IPC IPC(8): A61L31/12A61L31/06A61L31/00A61L31/16A61L31/14D01D5/00D04H1/4382D04H1/728
CPCA61L31/005A61L31/06A61L31/12A61L31/146A61L31/16A61L2400/12D01D5/003D01D5/0061D01D5/0069D01D5/0092D04H1/4382D04H1/728
Inventor 游正伟叶晓峰赵强雷东杨阳
Owner DONGHUA UNIV
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