Drug-carrying small-caliber intravascular stent and preparation method thereof
A vascular stent and a small-caliber technology are applied in the field of drug-loaded small-caliber vascular stents and their preparation, which can solve problems such as weight loss and drug effectiveness limitation, and achieve the advantages of promoting cell proliferation and migration, good application prospect and simple preparation method. Effect
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[0030] Example 1
[0031] 1. Definement processing and characterization of rat abdominal aorta
[0032] (1) SD rats (8 weeks old) were given 2% pentobarbital 40mg / kg (0.2ml / 100g) abdominal cavity anesthesia, the thoracic aorta was completely removed to the level above the iliac artery bifurcation and the descending aorta was placed Rinse repeatedly in sterile normal saline to remove blood clots in the aorta, and remove extravascular fat and connective tissue to obtain a natural undecellularized rat aorta (Native rataortas, NRA).
[0033] (2) Put the NRA in the decellularization solution, the decellularization solution is: PBS solution containing 0.5% Triton-X100, 0.5% sodium deoxycholate (SD) and 0.5% sodium dodecyl sulfonate (SDS) And PBS solution containing 20μg / ml RNAse and 200μg / ml DNAse. Finally, the decellularized aorta was placed in a PBS solution containing 1× penicillin-streptomycin double antibody solution to wash and shake to obtain decellularized rat aortas (DRA).
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