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Method for extracting and separating sesquiterpene lactone compounds from artemisia sacrorum ledeb

A technology of ester compounds and sesquiterpene, which is applied in the field of compound extraction, can solve the problem of inability to extract sesquiterpene lactone compounds, etc., and achieve the effect of high purity, high extraction efficiency and simple extraction method

Active Publication Date: 2019-11-05
JILIN NORMAL UNIV
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Problems solved by technology

[0005] The purpose of the present invention is to provide a method for extracting and separating sesquiterpene lactones from Artemisia persicae, so as to solve the problem that the existing sesquiterpene lactones cannot be extracted from Artemisia persicae except the above three sesquiterpene lactones. Technical Problems of Semiterpene Lactone Compounds

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  • Method for extracting and separating sesquiterpene lactone compounds from artemisia sacrorum ledeb

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Embodiment Construction

[0022] In order to enable those skilled in the art to better understand the purpose, technical solutions and advantages of the present invention, the present invention will be further described below in conjunction with specific examples, but the given examples are not intended to limit the present invention.

[0023] Instruments and reagents

[0024] INOVA-500MHz-FT nuclear magnetic resonance instrument (U.S. Varian company), TMS is an internal standard; Agilent 6320 mass spectrometer (U.S. Agilent company); Dionex Ultimate 3000 semi-preparative high-performance liquid chromatograph (U.S. Dionex company). Silica gel for thin-layer chromatography and column chromatography (Qingdao Ocean Chemical Factory), octadecylsilane bonded silica gel (ODS) column chromatography material (YMC Company, Japan); semi-preparative chromatography column Eclipse XDB-C18 (250mm×9.4mm, 5μm ) (Agilent Corporation, USA). The chromatographic methanol and acetonitrile used in HPLC were products of Fis...

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Abstract

The invention relates to a method for extracting and separating sesquiterpene lactone compounds from artemisia sacrorum ledeb. The sesquiterpene lactone compounds comprise 1alpha-acetoxyeudesm-4-en-6beta,11betaH-12,6-olide; (11S)-3-oxoeudesma-1,4(15)-dieno-12,6 alpha-lactone; 1-epi-dehydroisoerivanin; 11-epitaurin; chrysanthemolide; 1 alpha-acetyl-gallicadiol; erivanin; 1 alpha,4alpha-dihydroxyeudesm-2-en-5alpha,6beta,11betaH-12,6-olide; vulgarin; (+)-dehydrovomifoliol. The extracting and separating method comprises the steps that by adopting silica gel, an ODS open column and a semi-preparative liquid chromatography and other chromatographic methods, an ethyl acetate extraction part of a 95% ethyl alcohol extract of the artemisia sacrorum ledeb is separated and purified, and the above 10compounds are obtained through separation. The extraction method is simple, the extraction efficiency is high, the number of the extracted compounds is large, and a foundation is laid for the pharmacological study of the sesquiterpene lactone compounds.

Description

technical field [0001] The invention relates to the field of compound extraction, in particular to a method for extracting and separating sesquiterpene lactone compounds from Artemisia persicae. Background technique [0002] Sesquiterpene lactones are the active components of medicinal plants and widely exist in plants such as Euphorbiaceae, Acanthaceae, Umbelliferae, Magnoliaceae, Fangheceae and Compositae. Currently, more than 3000 structures of sesquiterpene lactones have been isolated from Compositae plants. Sesquiterpene lactones have anti-inflammatory, anti-viral and other activities, so how to effectively extract the active components of sesquiterpene lactones in medicinal plants to obtain products with higher purity, for sesquiterpene lactones The in-depth study of these compounds plays an important role. [0003] Since sesquiterpene lactones are chiral compounds, the three-dimensional environment is relatively complicated, and they are obtained by chemical synthes...

Claims

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Application Information

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IPC IPC(8): C07D307/92C07C49/647C07C45/78C07C45/79
CPCC07C45/78C07C45/79C07D307/92C07C2601/16C07C49/647
Inventor 孙艳涛赵磊冯静东张进刘仕聪刘云菲
Owner JILIN NORMAL UNIV
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