Preparation method of medical dressing

A stem cell and solution technology, used in medical science, absorbent pads, bandages, etc., can solve problems such as unsatisfactory effects, and achieve the effects of being conducive to wound repair, avoiding secondary trauma, and reducing the number of dressing changes.

Inactive Publication Date: 2019-11-12
深圳刚华健医疗有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the effect is not ideal

Method used

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  • Preparation method of medical dressing
  • Preparation method of medical dressing
  • Preparation method of medical dressing

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] (1) Preparation of PLGA sustained-release microspheres containing secretin

[0036] S1. Dissolve PLGA in dichloromethane to prepare a PLGA dichloromethane solution with a concentration of 10% (w / v);

[0037] S2. The stem cell secretin powder is dissolved in deionized water to prepare a stem cell secretin solution with a concentration of 2% (w / v). In this embodiment, the stem cell secretin is derived from human subtotipotent stem cells;

[0038] S3. Under the condition of vortexing and shaking, add the stem cell secretin solution dropwise to the PLGA dichloromethane solution and mix, and then phacoemulsify for 10 minutes under ice bath conditions to prepare W / O colostrum;

[0039] S4. Under the condition of vortex shaking, drop the W / O colostrum into the PVA aqueous solution with a concentration of 2.5% (w / v), and then intermittently use ultrasonic treatment under ice bath conditions to prepare W / O / W double breast; ultrasound conditions: 10-38% amplitude (418J), 10s pause every...

Embodiment 2

[0050] (1) Preparation of PLGA sustained-release microspheres containing secretin

[0051] S1. Dissolve PLGA in dichloromethane to prepare a PLGA dichloromethane solution with a concentration of 10% (w / v);

[0052] S2. The stem cell secretin powder is dissolved in deionized water to prepare a stem cell secretin solution with a concentration of 2.5% (w / v). In this embodiment, the stem cell secretin is derived from human subtotipotent stem cells;

[0053] S3. Under the condition of vortexing and shaking, add the stem cell secretin solution dropwise to the PLGA dichloromethane solution and mix, and then phacoemulsify for 10 minutes under ice bath conditions to prepare W / O colostrum;

[0054] S4. Under the condition of vortex shaking, drop the W / O colostrum into the PVA aqueous solution with a concentration of 3% (w / v), and then intermittently use ultrasonic treatment under ice bath conditions to make W / O / W double breast; ultrasound conditions: 10-38% amplitude (418J), 10s pause every 4s...

Embodiment 3

[0065] (1) Preparation of PLGA sustained-release microspheres containing secretin

[0066] S1. Dissolve PLGA in dichloromethane to prepare a PLGA dichloromethane solution with a concentration of 10% (w / v);

[0067] S2. The stem cell secretin powder is dissolved in deionized water to prepare a stem cell secretin solution with a concentration of 3% (w / v). In this embodiment, the stem cell secretin is derived from human subtotipotent stem cells;

[0068] S3. Under the condition of vortexing and shaking, add the stem cell secretin solution dropwise to the PLGA dichloromethane solution and mix, and then phacoemulsify for 10 minutes under ice bath conditions to prepare W / O colostrum;

[0069] S4. Under the condition of vortex shaking, drop the W / O colostrum into the PVA aqueous solution with a concentration of 3.5% (w / v), and then intermittently use ultrasonic treatment under ice bath conditions to make W / O / W double breast; ultrasound conditions: 10-38% amplitude (418J), 10s pause every 4s...

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Abstract

The invention provides a preparation method of a medical dressing, which includes preparation of secreted PLGA sustained-release microspheres, preparation of a hydrogel, preparation of an electrospunmembrane, and preparation of a stem cell secretion medical dressing. In the invention, a combination of sub-totipotent stem cell secretin, PLGA sustained-release microspheres and hyaluronic acid hydrogel is used, and the electrospun membrane is used as a carrier to prepare the medical dressing, the sub-totipotent stem cell secretion is rich in various active factors, and has a good repair effect on wounds; Experiments show that the medical dressing prepared by the invention has a good healing effect on both acute and chronic wounds. The medical dressing can adhere to the wound well, and the sub-totipotent stem cell secretin in the PLGA sustained-release microspheres is slowly released, which greatly improves the utilization rate of the secretion and the durability, the PLGA slow-release microspheres contain a larger amount of subtotipotent stem cell secretions, which reduces the number of dressing changes, avoids secondary trauma during the dressing change, and facilitates wound repair.

Description

Technical field [0001] The invention relates to the field of biotechnology, in particular to a method for preparing a medical dressing. Background technique [0002] Wound healing from wounds, surgery, and chronic diseases affect millions of people around the world every year. Promoting the healing of injuries caused by accidental and deliberate injuries and restoring tissue structure and function are still a difficult challenge in current clinical applications. The causes of poor skin healing are diverse, but generally can be divided into ulcerative skin defects (chronic wounds) and excessive scarring (hypertrophic scars or keloids). Chronic trauma mostly reshapes tissue structure and functional integrity through sequential repair processes, but vascular insufficiency, metabolic diseases and local pressure effects usually hinder this process. Diabetes is the most common metabolic disease, which can cause chronic wound regeneration to be blocked. It is estimated that by 2030, ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/40A61L15/26A61L15/24A61L15/28A61L15/20A61L15/42A61L15/44
CPCA61L15/20A61L15/24A61L15/26A61L15/28A61L15/40A61L15/42A61L15/44A61L2300/412A61L2300/602C08L67/04C08L29/04C08L5/08
Inventor 王彬林思恩李刚
Owner 深圳刚华健医疗有限公司
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