Manufacturing method and application of 3D printing hollow microneedles

Abstract

The invention discloses a manufacturing method and application of 3D printing hollow microneedles, and belongs to the field of biological materials. Through the micro stereoscopic photocuring formingtechnology in the 3D printing technology, a light-sensitive material with good biocompatibility serves as a printing material, and a Form 2 photocuring printing machine is utilized for printing out hollow microneedle arrays of different needle point structures and different parameters. Through parameter analog computation and optimization, the hollow microneedle arrays high in mechanical performance and high in agent discharge rate are selected out to be used for experiments. Inner hole diameters of the optimized 3D printing hollow microneedle arrays can be observed under a microscopic device,and mouse skins can be punctured successfully. The 3D printing hollow microneedles, a piezoelectric micropump and the like are packaged and integrated into a minimally invasive insulin infusion system, the minimally invasive insulin infusion system is used for intelligent in-vivo blood glucose regulation, the 3D printing hollow microneedle arrays can achieve controllable insulin release under theaction of the piezoelectric micropump, and in-vivo blood glucose is successfully regulated.

Description

technical field [0001] The invention belongs to the field of biological materials, and more specifically relates to a method for manufacturing 3D printed hollow microneedles and its application. Background technique [0002] Diabetes mellitus is a common endocrine and metabolic disease. The main cause is insufficient insulin secretion, or some factors that resist insulin affect its physiological function, causing metabolic disorders of glucose in the blood. The traditional way of treating diabetes is to use finger blood sampling and blood sugar detection, and perform subcutaneous insulin injection to control blood sugar. The traditional method of using a needle to inject insulin subcutaneously has many disadvantages. Needling requires special skills and techniques, and it is extremely painful for diabetic patients who are faint of needles and afraid of needles. The microneedle technology emerging in recent years is expected to solve this problem, and has gradually become a ...

AI Technical Summary

Problems solved by technology

[0004] Aiming at the above defects or improvement needs of the prior art, the present invention proposes a manufacturing method and application of 3D printed hollow microneedles, thereby solving the problem of biocompatibility and safety of existing silicon microneedles and metal microneedles. The problem

Images