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Benzoisofuran compound, preparation method and applications thereof

A technology of benzoisofuran and compound is applied in the field of benzoisofuran compound and preparation thereof, can solve problems such as no reports, and achieve the effects of simple preparation process, easy realization and good anti-tobacco black stem disease activity

Active Publication Date: 2019-11-19
YUNNAN ACAD OF TOBACCO AGRI SCI +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Based on the above considerations, we studied the chemical constituents of the dried whole plant of Phyllostachys chinensis from Yunnan, and isolated a new benzisofuran compound, which has not been reported so far

Method used

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  • Benzoisofuran compound, preparation method and applications thereof
  • Benzoisofuran compound, preparation method and applications thereof
  • Benzoisofuran compound, preparation method and applications thereof

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preparation example Construction

[0036] The preparation method of the benzoisofuran compounds described in the present invention is based on the lentil lentils as raw material, and is subjected to extraction from extract, silica gel column chromatography and high-pressure liquid chromatography separation and purification steps, specifically comprising:

[0037] A. Extraction: Grind and sieve the lentil lentils, use 3 to 10 times the weight of lentil lentils for ultrasonic extraction 3 to 5 times, 30 to 60 minutes each time, combine the extracts and concentrate to obtain a flowable viscous Thick extract a;

[0038] B. Silica gel column chromatography: use 160-300 mesh silica gel dry method packing 2-8 times the weight of extract a for extract a to carry out silica gel column chromatography, and the volume ratio is 1:0, 20:1, 9 :1, 8:2, 7:3, 6:4, 1:1 and 1:2 chloroform-acetone solutions for gradient elution, collect the gradient elution, concentrate, and combine the same parts;

[0039] C. High pressure liquid...

Embodiment 1

[0049] The preparation of embodiment 1-compound

[0050] The samples of lentil lentils were from Honghe, Yunnan. Sampling 2.5 kg of dried lentil lentils was crushed and extracted 5 times with 95% methanol for 45 minutes each time. The extracts were combined, filtered, concentrated under reduced pressure to obtain an extract, and 165 g of extract was obtained. The extract was dissolved in pure methanol with a weight ratio of 2.0 times, and then mixed with 180 g of 100-mesh crude silica gel, and 1.2 kg of 160-mesh silica gel was packed into a column for silica gel column chromatography, and the volume ratio was 1:0, 20:1 , 9:1, 8:2, 7:3, 6:4, 1:1, 1:2 chloroform-acetone gradient elution, TLC monitoring and merging the same parts to obtain 8 parts, wherein the volume ratio is 9 The chloroform-acetone elution part of :1 is separated by Agilent 1100 semi-preparative high-performance liquid chromatography, with 68% methanol as mobile phase, Zorbax SB-C18 (21.2 250mm,5 ) The pr...

Embodiment 2

[0051] The preparation of embodiment 2-compound

[0052] The lentil lentil sample comes from Baise, Guangxi. The dried lentil lentil sample was crushed to 30 mesh, 4.2 kg was sampled, and extracted 4 times with 95% ethanol for 40 minutes each time. The extracts were combined, filtered, and decompressed. Concentrate into an extract to obtain 302 g of extract. The extract was dissolved in pure methanol with a weight ratio of 2.0 times, and then mixed with 320 g of 80-mesh crude silica gel, and 2.2 kg of 200-mesh silica gel was packed into a column for silica gel column chromatography, and the volume ratio was 1:0, 20:1. , 9:1, 8:2, 7:3, 6:4, 1:1, 1:2 chloroform-acetone gradient elution, TLC monitoring and merging the same parts to obtain 8 parts, wherein the volume ratio is 9 The chloroform-acetone elution part of :1 is separated by Agilent 1100 semi-preparative high-performance liquid chromatography, with 68% methanol as mobile phase, Zorbax SB-C18 (21.2 250 mm, 5 ) The pr...

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Abstract

The invention discloses a benzoisofuran compound, a preparation method and applications thereof, wherein the benzoisofuran compound is separated from Cassia pumila Lam, is named 9-(2-hydroxyethyl)-2,2-dimethyl-2H-furo[3,4-g]chromen-6(8H)-one, has an English name of 9-(2-hydroxyethyl)-2,2-dimethyl-2H-furo[3,4-g]chromen-6(8H)-one, has a molecular formula of C15H16O4, is a yellow gum, and has a structural formula defined in the specification. The preparation method comprises: extract extracting, silica gel column chromatography and high pressure liquid chromatography separation and purification.According to the present invention, the benzoisofuran compound can be used in preparation of antibacterial agents, or in preparation of biological pesticides against Tobacco black shank.

Description

technical field [0001] The invention belongs to the technical field of phytochemistry, and in particular relates to a benzisofuran compound and a preparation method and application thereof. Background technique [0002] Lentil lentils (Latin name: Cassia pumila Lam.) is a perennial subshrub-like herbaceous plant of the genus Cassia in the Fabaceae family, which grows in bushes or grasses in mountains and open areas. In my country, it is mainly distributed in the subtropical regions of Guangdong, Yunnan, Guangxi and other provinces. It is also distributed in India, Indochina Peninsula, Malaysia, Australia, etc. Cassia plants are traditional medicinal plants in my country, which have a very wide range of uses and a long history of medicinal use among the people. It is reported in the literature that the chemical components of Cassia plants are mainly flavonoids and anthraquinones, in addition to terpenes, steroids, alkaloids, chromones, etc. At present, there are very few...

Claims

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Application Information

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IPC IPC(8): C07D493/04A01N43/90A01P1/00A01P3/00
CPCA01N43/90C07D493/04
Inventor 孔光辉吴玉萍师君丽李薇胡秋芬杨光宇李晶宋春满刘欣黄海涛李雪梅
Owner YUNNAN ACAD OF TOBACCO AGRI SCI