Preparation method of novel dextrin and application of the novel dextrin in dialysate

A technology of peritoneal dialysis fluid and dextrin, applied in the field of peritoneal dialysis, can solve the problems of large osmotic pressure range, large dextrin molecular number range, etc., and achieve the effects of narrow osmotic pressure range, concentrated range and broad market application prospect.

Pending Publication Date: 2019-11-22
西安乐析医疗科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] The purpose of the present invention is to provide a novel preparation method of dextrin and its application in dialysate, to solve the problem of large osmotic pressure range caused by the large range of dextrin molecules

Method used

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  • Preparation method of novel dextrin and application of the novel dextrin in dialysate
  • Preparation method of novel dextrin and application of the novel dextrin in dialysate

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preparation example Construction

[0027] In order to solve the problem of large osmotic pressure range caused by the large range of existing dextrin molecules, the present invention provides a preparation method of novel dextrin and its application in dialysate, specifically the dextrin prepared by the method of the present invention is used as Application of osmotic agents in dialysate. The acid described in the method of the present invention is hydrochloric acid, glacial acetic acid or sulfuric acid, wherein said hydrochloric acid can be concentrated hydrochloric acid, also can be the dilute hydrochloric acid of mass percent concentration ≥ 10%, and described sulfuric acid can be concentrated sulfuric acid, also can be mass percent Dilute sulfuric acid with a percentage concentration ≥ 10%. The membrane bag used in the present invention is GK1812 model and PT1812 model of SUEZ company, also can be replaced by other products with the same effect. The model of the spray dryer used is Yacheng YC-019, and it c...

Embodiment 1

[0031] Add 10,000ml of water to the reaction kettle, start stirring, then add 10,000g of cornstarch, and after stirring evenly, make a starch slurry with a mass percentage concentration of 50%, add 10% dilute hydrochloric acid to make the mass percentage concentration of the acid in the entire system 3%, keep it warm at 65°C, carry out the hydrolysis reaction for 6 hours, add 5 times the amount of cooling water to cool the reaction solution to room temperature, first filter it with a Suez GK1812 3000 membrane, remove the substances with a molecular weight less than 3000, and retain the large molecular weight Parts, and then filter with PT1812 5000 membrane to remove substances with molecular weight greater than 5000, retain the part with molecular weight less than 5000, collect the molecular weight of substances in the liquid with a molecular weight of 3000-5000, and then use Yacheng YC-019 spray dryer to spray Drying at a drying temperature of 150° C., a drying time of 8 hours...

Embodiment 2

[0033] Add 10,000ml of water to the reaction kettle, start stirring, then add 6666.7g of potato starch, and after stirring evenly, make a starch slurry with a mass percentage concentration of 40%, add 37% concentrated hydrochloric acid to make the mass percentage of the acid in the whole system The concentration is 5%, the temperature is kept at 70°C, the hydrolysis reaction is carried out for 5 hours, 8 times the amount of cooling water is added to cool the reaction solution to room temperature, and the membrane filter with Suez GK1812 3000 is used to remove the substances with a molecular weight less than 3000, and the molecular weight The larger part is then filtered with a PT1812 5000 membrane to remove substances with a molecular weight greater than 5000, and retain the part with a molecular weight less than 5000. The molecular weight of the substances in the collected liquid is 3000-5000, and then use Yacheng YC-019 spray dryer for Spray drying, drying temperature 120 ° C...

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Abstract

The invention belongs to the technical field of peritoneal dialysis, and particularly relates to a preparation method of novel dextrin and application of the novel dextrin in dialysate. The preparation method comprises the following steps: (1) preparing starch slurry by taking starch as a raw material and water as a solvent, adding acid to carry out hydrolysis reaction, and then adding water to terminate the reaction so as to obtain a reaction solution 1; (2) filtering the reaction solution 1 through a membrane pack to remove substances with the molecular weight of less than 3000 in the reaction solution, so as to obtain a reaction solution 2; (3) filtering the reaction solution 2 through a membrane pack to remove substances with the molecular weight larger than 5000 in the reaction solution to obtain a reaction solution 3, with the molecular weight of the substances in the reaction solution 3 being 3000-5000; and (4) carrying out spray drying on the reaction solution 3 through a spraydryer to obtain dextrin powder. The molecular weight distribution range of the obtained dextrin is narrower, the range is more centralized, the molecular weight is small, and the product quality is relatively uniform, so that the osmotic pressure range is narrower, and the dosage is easy to control.

Description

technical field [0001] The invention belongs to the technical field of peritoneal dialysis, and in particular relates to a preparation method of novel dextrin and its application in dialysate. Background technique [0002] The peritoneal dialysis solution listed in my country is imitating the foreign dialysis solution using glucose as the osmotic agent. Glucose as the osmotic agent has the advantages of light toxic and side effects, easy to obtain raw materials, and economic convenience. But there are also such shortcomings, that is, glucose will be absorbed into the blood through the peritoneum, so that there is no concentration difference and the osmotic effect is lost. Therefore, the dialysate with glucose as the osmotic agent needs to use 4 bags a day. [0003] The peritoneal dialysis solution using icodextrin as the osmotic agent does not have the above-mentioned problems, will not lose osmotic pressure, and only uses one bag a day. At present, there is no such product...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08B30/18A61K31/718A61P7/08
CPCA61K31/718A61P7/08C08B30/18
Inventor 李继仁赵峰梁志兴李云峰康战国
Owner 西安乐析医疗科技有限公司
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