Hemostatic composite material and preparation method thereof

A composite material and hydrophilic polymer technology, which is applied in the field of hemostatic composite materials grafted with lithium magnesium silicate and hydrophilic polymers and its preparation, can solve the problems of poor dispersibility of lithium magnesium silicate, poor dispersibility of composite hemostatic materials, Inconvenient clinical operation for doctors and other problems, to achieve good hemostasis effect

Active Publication Date: 2021-11-09
CHENGDU MEDART MEDICAL SCI CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the dispersibility of lithium magnesium silicate in water is poor, and the hydrogel needs to be continuously sheared by high-speed stirring to form a hydrogel, which brings great inconvenience to doctors in clinical operations.
Although the hemostatic hydrogel formed by direct physical blending and stirring of commonly used biomacromolecules (eg, gelatin) and lithium magnesium silicate can improve the mechanical properties and poor adhesion of the gelatin hemostatic sponge, and has a better hemostatic effect, However, the composite hemostatic material obtained in this way still has the problem of poor dispersion in water

Method used

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  • Hemostatic composite material and preparation method thereof

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[0030] The preparation method of the hemostatic composite material of the present invention comprises the following steps: (1) mixing lithium magnesium silicate, a hydrophilic polymer, and a solvent to form a mixed suspension; (2) drying the mixed suspension to remove part Solvent; react the dried suspension under heating conditions, then cool and pulverize to obtain large particles of magnesium silicate grafted hydrophilic polymer; (3) graft lithium magnesium silicate with hydrophilic polymer The large particles are mixed with water, swollen and dispersed to obtain a lithium magnesium silicate grafted hydrophilic polymer hydrogel; (4) pre-freezing the lithium magnesium silicate grafted hydrophilic polymer hydrogel, and then freeze-drying, The magnesium lithium silicate grafted hydrophilic polymer with a porous structure is obtained; and then the porous magnesium lithium silicate grafted hydrophilic polymer is pulverized to obtain a hemostatic composite material.

[0031] The ...

Embodiment 1

[0049] The solvent (volume ratio of ethanol, acetone and water is 1:3:7) that 1.5g hydroxypropyl chitosan is formed with 28ml ethanol, acetone and water is mixed to form a mixed solution; 0.6g lithium magnesium silicate (silicon Lithium magnesium oxide is a flaky crystal with a diameter of 20nm and a thickness of 0.8nm) added to the mixed solution, and ultrasonicated at 150kHz for 60min to form a mixed suspension.

[0050] Dry the mixed suspension at 70°C for 4 hours to remove ethanol and acetone in the solvent; react the dried suspension at 120°C for 4 hours, then cool to room temperature and pulverize to obtain magnesium silicate with an average particle size of 300 μm Lithium-grafted hydrophilic polymer large particles.

[0051] Add 2 g of the prepared large particles of lithium magnesium silicate grafted hydrophilic polymer to 30 ml of deionized water, and stir for 4 minutes at 50° C. to swell and disperse the large particles of lithium magnesium silicate grafted hydrophil...

Embodiment 2

[0054] 1.6g chitosan hydrochloride is mixed with the solvent (the volume ratio of isopropanol, acetone and water is 1:3:7) that 28ml isopropanol, acetone and water are formed to form a mixed solution; 0.8g silicic acid Magnesium lithium (lithium magnesium silicate is a plate-like crystal with a diameter of 25nm and a thickness of 1.1nm) was added to the mixed solution, and ultrasonic was applied at 150kHz for 60min to form a mixed suspension.

[0055] Dry the mixed suspension at 70°C for 5 hours to remove isopropanol and acetone in the solvent; react the dried suspension at 120°C for 4 hours, then cool to room temperature and pulverize to obtain silicic acid with an average particle size of 300 μm Magnesium lithium grafted hydrophilic polymer large particles.

[0056] Add 2 g of the prepared large particles of lithium magnesium silicate grafted hydrophilic polymer to 30 ml of deionized water, and stir for 4 minutes at 50° C. to swell and disperse the large particles of lithium...

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Abstract

The invention discloses a hemostatic composite material and a preparation method thereof. The hemostatic composite material uses lithium magnesium silicate as the core, and a hydrophilic polymer is grafted around it, and has a porous structure; the hydrophilic polymer The material is selected from one of chitosan, hydroxyalkyl chitosan, carboxyalkyl chitosan, chitosan salt, polyethylene glycol, polyvinyl alcohol, polymethacrylic acid-β-hydroxyethyl ester or Various. The hemostatic composite can be quickly configured into a hydrogel.

Description

technical field [0001] The invention relates to a hemostatic composite material and a preparation method thereof, in particular to a hemostatic composite material grafted with lithium magnesium silicate and a hydrophilic polymer and a preparation method thereof. Background technique [0002] Gelatin hemostatic sponge is currently the most commonly used hemostatic material clinically, as CN108530671A discloses a porous gelatin sponge, but the mechanical properties and adhesion of gelatin hemostatic sponge are relatively poor, and it is prone to rupture or fall off due to the pressure of bleeding out , In addition, for the wound site with narrow space, the gelatin hemostatic sponge is difficult to reach, and it cannot achieve the purpose of complete hemostasis. [0003] Lithium magnesium silicate is a thixotropic hydrogel that can be dispersed in water to form a high degree of adhesion. The formed hydrogel has good mechanical properties and can quickly block and stop bleeding ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L26/00C08G83/00
CPCA61L26/0085A61L26/0095A61L2400/04C08G83/001
Inventor 杨满张晓金王军
Owner CHENGDU MEDART MEDICAL SCI CO LTD
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