Vagina injection agent for treating uterine prolapse and preparation method of vagina injection agent

A technology for uterine prolapse and injection, which is applied in the field of medicine, can solve the problems of pessary that cannot achieve a radical effect, low content of active ingredients, and great influence on patients, and achieves the effects of improving vaginal microenvironment, high drug concentration, and difficulty in recurrence.

Pending Publication Date: 2019-12-03
广东圆康再生医学科技开发有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, placing a pessary cannot achieve a radical cure effect, and has a great impact on the patient. The pessary will cause vaginal irritation and ulcers, and may also cause incarceration, fistula formation, bleeding, infection, etc.; it also needs to be taken out and cleaned intermittently , reposition
Traditional Chines

Method used

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  • Vagina injection agent for treating uterine prolapse and preparation method of vagina injection agent
  • Vagina injection agent for treating uterine prolapse and preparation method of vagina injection agent
  • Vagina injection agent for treating uterine prolapse and preparation method of vagina injection agent

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] A vaginal injection for treating uterine prolapse, which consists of the following components by weight: 13 parts of β-glucan, 5 parts of Lycium barbarum polysaccharide, 5 parts of chitosan oligosaccharide, 10 parts of recombinant human serum albumin, 10 parts of recombinant human 0.3 parts of interleukin-22, 0.3 parts of recombinant human interleukin-4, 1 part of recombinant human epidermal growth factor, 12 parts of active lactic acid bacteria powder, 0.5 parts of penetration enhancer, 3 parts of bioadhesive agent, 50 parts of buffer And 80 parts of normal saline.

[0030] The active lactic acid bacteria powder is composed of Lactobacillus bulgaricus powder, Lactobacillus acidophilus powder and Lactobacillus salivarius powder, and by mass ratio, Lactobacillus bulgaricus powder: Lactobacillus acidophilus powder: Lactobacillus salivarius powder=1:1:4 .

Embodiment 2

[0032] A vaginal injection for treating uterine prolapse, which consists of the following components by weight: 5 parts of oat β-glucan, 10 parts of wolfberry polysaccharide, 8 parts of chitosan oligosaccharide, 15 parts of recombinant human serum albumin, recombinant 0.5 parts of human interleukin-22, 0.2 parts of recombinant human interleukin-4, 0.3 parts of recombinant human epidermal growth factor, 15 parts of active lactic acid bacteria powder, 0.6 parts of water-soluble azone, 4 parts of sodium carboxymethyl cellulose, 60 parts of sodium acetate-acetic acid buffer solution (pH=4.5) and 50 parts of normal saline.

[0033] The active lactic acid bacteria powder is composed of Lactobacillus bulgaricus powder, Lactobacillus acidophilus powder and Lactobacillus salivarius powder, and by mass ratio, Lactobacillus bulgaricus powder: Lactobacillus acidophilus powder: Lactobacillus salivarius powder=1:1:4 .

Embodiment 3

[0035] A vaginal injection for treating uterine prolapse, which consists of the following components by weight: 10 parts of oat β-glucan, 1 part of wolfberry polysaccharide, 10 parts of chitosan oligosaccharide, 12 parts of recombinant human serum albumin, recombinant 0.4 parts of human interleukin-22, 0.4 parts of recombinant human interleukin-4, 1 part of recombinant human epidermal growth factor, 11 parts of active lactic acid bacteria powder, 1 part of water-soluble azone, 5 parts of sodium carboxymethyl cellulose, 60 parts of sodium acetate-acetic acid buffer (pH=4.5) and 60 parts of normal saline.

[0036] The active lactic acid bacteria powder is composed of Lactobacillus bulgaricus powder, Lactobacillus acidophilus powder and Lactobacillus salivarius powder, and by mass ratio, Lactobacillus bulgaricus powder: Lactobacillus acidophilus powder: Lactobacillus salivarius powder=1:1:4 .

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Abstract

The invention discloses a vagina injection agent for treating uterine prolapse. The vagina injection agent is prepared from the following components in parts by weight: 5-20 parts of beta-glucan, 1-10parts of lycium barbarum polysaccharide, 1-10 parts of chitosan oligosaccharide, 5-15 parts of recombinant human serum albumin, 0.05-0.5 part of recombinant human interleukin-22, 0.1-0.6 part of recombinant human interleukin-4, 0.3-1.5 parts of a recombinant human epidermal growth factor, 10-15 parts of active lactobacillus powder, 0.1-1 part of a penetration enhancer, 1-5 parts of a bio-adhesiveagent, 40-60 parts of a buffer solution and 50-100 parts of normal saline. The vagina injection agent directly acts on lesion parts, local drug concentration is high, the vagina micro-environment canbe effectively improved, the micro-ecological balance in a vagina and the normal micro-environment of a cervix are maintained, and local and body immune functions are improved; and the vagina injection agent can further promote cell regeneration, promote collagen synthesis, improve skin elasticity, accelerate repair of damaged tissue, promote tension recovery of pelvic floor muscles, fascia and uterus ligament, and can effectively improve uterine prolapse; and recurring is not prone to appearing after cure, using is convenient and safe, and the effect is fast.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a vaginal injection for treating uterine prolapse and a preparation method thereof. Background technique [0002] Uterine prolapse refers to the descent of the uterus from the normal position along the vagina, the external opening of the cervix reaches below the level of the ischial spine, or even the entire uterus prolapses beyond the opening of the vagina, often accompanied by bulging of the anterior and / or posterior walls of the vagina. Clinically, the main manifestations are that the patient feels that the abdomen is falling, and the back is sore, which is more obvious when walking and squatting. In mild prolapse patients, the vaginal prolapse can be recovered by itself after resting on the supine position, but in severe cases, the prolapse cannot be recovered, which affects the movement. The cervix is ​​thickened, keratinized, or eroded and ulcerated due to long-term expos...

Claims

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Application Information

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IPC IPC(8): A61K9/00A61K47/36A61K38/38A61K38/20A61K38/18A61P15/00A61K35/744
CPCA61K9/0034A61K47/36A61K38/385A61K38/2026A61K38/20A61K38/1808A61K35/744A61P15/00A61K2300/00
Inventor 邱建华
Owner 广东圆康再生医学科技开发有限公司
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