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A kind of salt of benzopiperidine derivatives, its crystal form and salt, the preparation method of its crystal form

A crystal form and crystallization technology, which is applied in the field of preparation of salts of benzopiperidine derivatives, their crystal forms, salts, and their crystal forms, can solve the problems of affecting druggability, low solubility of compounds, and poor fluidity

Active Publication Date: 2022-07-26
JIANGSU HENGRUI MEDICINE CO LTD +1
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0008] But, the solubility of the compound shown in formula (II) is low, affects its druggability
In addition, amorphous pharmaceutical products have no regular crystal structure and often have other defects, such as poor product stability, fine crystallization, difficult filtration, easy agglomeration, poor fluidity, etc.

Method used

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  • A kind of salt of benzopiperidine derivatives, its crystal form and salt, the preparation method of its crystal form
  • A kind of salt of benzopiperidine derivatives, its crystal form and salt, the preparation method of its crystal form
  • A kind of salt of benzopiperidine derivatives, its crystal form and salt, the preparation method of its crystal form

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Embodiment Construction

[0042] In the specification and claims of the present application, unless otherwise specified, scientific and technical terms used herein have the meanings commonly understood by those skilled in the art. However, for a better understanding of the present invention, definitions and explanations of some related terms are provided below. In addition, when the definitions and explanations of terms provided in this application are inconsistent with the meanings commonly understood by those skilled in the art, the definitions and explanations of terms provided in this application shall prevail.

[0043] The term "halogenated" in the present invention refers to substitution by a "halogen atom", and the "halogen atom" refers to a fluorine atom, a chlorine atom, a bromine atom, an iodine atom and the like.

[0044] The "C" of the present invention 1-6 "Alkyl" means a straight or branched chain alkyl group containing 1-6 carbon atoms, specific examples include but are not limited to: ...

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Abstract

Disclosed are a salt of a benzopiperidine derivative, a crystal form thereof, a preparation method of the salt and the crystal form thereof. Specifically, (E)-3-(4-((1R,3R)-2-(4-cyclopropylphenyl)-6-(1-ethyl-1H-pyrazole-4-yl) is disclosed -3-methyl-1,2,3,4-tetrahydroisoquinoline-1-yl) phenyl) acrylic acid L-lysine salt, its I crystal form and preparation method thereof. The compound of formula (I) and its crystal form I have good stability, simple process and easy operation, and can be better used for clinical treatment.

Description

[0001] This application claims the priority of Chinese patent application CN201710466845.3 with an application date of June 20, 2017. This application cites the full text of the above Chinese patent application. technical field [0002] The present invention relates to (E)-3-(4-((1R,3R)-2-(4-cyclopropylphenyl)-6-(1-ethyl-1H-pyrazol-4-yl)-3 -The salt of methyl-1,2,3,4-tetrahydroisoquinolin-1-yl)phenyl)acrylic acid, its crystal form and salt, the preparation method of its crystal form, and the salt, its crystal form in the preparation Use in a medicament for the prevention and / or treatment of estrogen receptor-mediated or dependent diseases or conditions. Background technique [0003] Estrogen is a steroid hormone secreted by the endocrine system and plays an important role in the reproductive system, bone tissue, cardiovascular, immune system and central nervous system. The estrogen signaling system plays an important role in regulating cell growth, differentiation and apop...

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Application Information

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IPC IPC(8): C07D401/04A61K31/4725A61P35/00
CPCA61K31/4725A61P35/00C07D401/04
Inventor 尤凌峰邵成冯君
Owner JIANGSU HENGRUI MEDICINE CO LTD
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