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Levornidazole and sodium chloride injection and preparation process thereof

A levonidazole sodium chloride, preparation technology, applied in sanitary equipment for toilets, medical preparations containing active ingredients, organic active ingredients, etc., can solve the problems of increased filtration costs, loss of drug efficacy, etc., to achieve Good sterilization effect, reduce the total amount of bacteria, reduce the effect of adsorption time

Inactive Publication Date: 2019-12-06
SICHUAN TAIPINGYANG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] Therefore, in the existing production method of injecting levonidazole and sodium chloride injection, it is desired to better control the number of bacteria, but also to worry about the loss of drug efficacy and increase the cost of filtration, which is a contradiction that is difficult to solve.

Method used

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  • Levornidazole and sodium chloride injection and preparation process thereof
  • Levornidazole and sodium chloride injection and preparation process thereof
  • Levornidazole and sodium chloride injection and preparation process thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0055] Prepare 100ml of infusion bags containing 250mg of levonidazole sodium chloride injection.

[0056] The ratio is as follows:

[0057] prescription inputs Levonidazole 0.25g 0.1M hydrochloric acid 0.9ml Sodium chloride 0.87g Water for Injection 100ml

Embodiment 2

[0059] Prepare 100ml of infusion bags containing 500mg of levonidazole sodium chloride injection.

[0060] The ratio is as follows:

[0061]

[0062]

Embodiment 3

[0064] Prepare the infusion bag of levonidazole sodium chloride injection.

[0065] Concentrated formulation: add 80% of the prescribed amount of water for injection into the concentrated formulation tank, keep the water temperature at 50°C, add 0.1M hydrochloric acid (1ml / 100ml), sodium chloride in the prescribed amount and left-ornidazole in sequence, and stir to dissolve completely.

[0066] Moisten the activated carbon with water for injection to a water content of 7%, and then put 0.03% diluted activated carbon into the thick preparation tank, and stir at 50°C for 15 minutes.

[0067] Dilute preparation: decarbonize the liquid medicine in the concentrated preparation tank through a titanium rod filter, and transport it to the thin preparation tank. Rinse the concentrated preparation tank twice with water for injection. In the tank, adjust the pH value to 3.4-3.6 with 0.1M hydrochloric acid, and add water for injection to the full amount.

[0068] Intermediate inspection:...

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PUM

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Abstract

The invention relates to a levornidazole and sodium chloride injection and a preparation process thereof. The levornidazole and sodium chloride injection is prepared from levornidazole, 0.1 M hydrochloric acid, sodium chloride and injection water. The preparation process of the levornidazole and sodium chloride injection comprises the steps that the 0.1 M hydrochloric acid, the sodium chloride andthe levornidazole are put into the injection water, and stirring for dissolving is conducted; and activated carbon is utilized for adsorption, after decarbonization, liquid medicine is injected intoa diluting preparation tank for adjusting a pH value, the injection water is added to the full amount, an intermediate is checked, and then filling is conducted. The levornidazole and sodium chlorideinjection has a better therapeutic effect. The invention provides the novel production preparation process of the levornidazole and sodium chloride injection. The production preparation process has abetter sterilization effect.

Description

technical field [0001] The invention relates to an injection and a preparation process. It belongs to the field of injection medicine production. Background technique [0002] Levonidazole Sodium Chloride Injection is indicated for the treatment of bacterial infections caused by Bacteroides fragilis, Bacteroides distarii, Bacteroides ovale, Bacteroides polymorpha, Bacteroides vulgaris, Clostridium, Eubacterium, Peptococcus And a variety of infectious diseases caused by sensitive anaerobic bacteria such as Peptostreptococcus, Helicobacter pylori, Bacteroides melaninus, Fusobacterium, C02 Phagophagy, Bacteroides gingivalis, etc., and it is used to prevent infection before surgery and anaerobic after surgery treatment of bacterial infections. The human preparation ratio of levonidazole sodium chloride injection has never been better, so that the existing levonidazole sodium chloride injection has low drug efficacy, and the therapeutic effect needs to be further improved. [...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/08A61K31/675A61P31/04A61L2/025A61L2/02
CPCA61K9/0019A61K9/08A61K31/675A61L2/0011A61L2202/21A61P31/04
Inventor 张加宇许艳春文娟王利华
Owner SICHUAN TAIPINGYANG PHARMA