Formulations of cannabinoids for the treatment of dermatitis and inflammatory skin diseases
An inflammatory skin, cannabinoid technology, used in skin diseases, anti-inflammatory agents, non-central pain relievers, etc., can solve problems such as stiffness, pigmentation changes, aging skin, etc.
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Embodiment 1
[0239] Exemplary techniques for determining the permeability of compositions comprising cannabidiol.
[0240] The permeability of human skin has been studied for decades. The skin consists of two main layers, the outer epidermis and the inner dermis. The stratum corneum ("SC") is the outermost 10-20 μm of the epidermis and is responsible for the skin's great diffusion resistance to transdermal delivery of most drugs. Most skin enzyme activity is dependent on the basal cell layer of the living epidermis. Fibrous collagen is the main structural component of the dermis. Skin vasculature is supported by this collagen and lies a few micrometers below the epidermis. Basically, penetration ends here and systemic uptake begins. Many researchers have established skin permeability relationships based on the physicochemical parameters of skin penetrants (molecular weight, molecular volume, lipophilicity, hydrogen bond potential, polarity, etc.). However, when dealing with the transd...
Embodiment 2
[0247] Purpose:
[0248] Formulations of cannabidiol with silicone and other excipients are prepared.
[0249] Methods and results:
[0250] First, the solubility of cannabidiol (CBD) was assessed. The powder appears granular under the microscope. The solubility (w / w) of CBD in hexamethyldisiloxane (HDS) and mineral oil is less than about 3-4%. Although the reported solubility in ethanol is 3.5%, the solubility in propylene glycol (PG) and ethanol is about 6-7%. Solubility in oleyl alcohol (OA) was greater than 8% (did not trend higher in the study) and in isopropanol (IPA) was greater than 14%. Solubility studies concluded that OA and IPA are very good solvents, surprisingly IPA is much better than ethanol. Solubility in HDS and mineral oil is low, so fully non-polar solvents do not dissolve high levels of CBD well, but adding the OH groups present in fatty alcohols does increase CBD solubility.
[0251] Second, CBD is dissolved in a medium concentration in a highly vol...
Embodiment 3
[0275] Purpose:
[0276] Other formulations of cannabidiol with silicone and other excipients were prepared.
[0277] method:
[0278] CBD2 is an off-white crystalline powder that produces a clear solution in stark contrast to the CBD1 solution, which changes color by the end of the day. None of the CBD2 solutions had changed color and appeared clear by the end of day 1. CBD2 material dissolves like CBD1, so CBD2 is CBD without the color-changing properties of CBD1.
[0279] preparation
[0280] Formulation A (Type A)
[0281] 5%CBD / 2.5%HDA / 1%PMS / 91.5%HDS
[0282] Acne "spray" formulation A-7 was repeated and it behaved the same except it did not have any discoloration and was clear. It showed no signs of discolouration by the end of the day.
[0283] Tests performed:
[0284] a) Put a drop on the microscope slide, covering about 1cm 2 , no crystals appeared, but crystals did appear when rubbed vigorously with a finger (which caused crystal growth) later in the day (a...
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