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Patch for skin anesthesia and preparation method thereof

A skin and anesthetic technology, applied in the field of drug preparation and application, can solve the problems of poor anesthesia process experience, uneven drug effect, complicated operation, etc., to achieve strong anesthesia effect, promote product penetration, and ensure the effect of anesthesia effect.

Pending Publication Date: 2019-12-13
西安博和医疗科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The products protected by the technical features recorded in the patent CN100443078C are used in the same way as cream products. They still need to be applied to a certain thickness and covered with a covering film. The drug effect is uneven and unstable, the operation is cumbersome, and the experience of the anesthesia process is poor

Method used

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  • Patch for skin anesthesia and preparation method thereof
  • Patch for skin anesthesia and preparation method thereof

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preparation example Construction

[0053] Another aspect of the present invention provides the preparation method of the above skin anesthesia patch, comprising the following steps:

[0054] Take water and transdermal absorbent and mix them evenly to obtain a solvent phase; take thickener and film-forming material and disperse them in the solvent phase under stirring at a speed of 300rpm~1500rpm, and stir evenly to form a gel matrix; combine anesthetics and antibacterial Add the agent into the gel matrix under stirring, stir and mix to obtain a gel; pour the gel into an applicator mold, freeze at -10~-20°C for 4 hours, and thaw at 20-25°C for 4 hours , After 2-3 rounds of freezing and thawing, a patch for skin anesthesia is formed.

[0055] In the above method, the transdermal absorbent is selected from propylene glycol, ethanol and menthol, and the parts by weight of the propylene glycol are 10 parts, 11 parts, 12 parts, 13 parts, 14 parts, 15 parts, 16 parts, 17 parts , 18 parts, 19 parts, 20 parts, 21 parts...

Embodiment 1

[0068] This embodiment provides an application for skin anesthesia. According to parts by weight, the application for skin anesthesia is prepared from the following components: 2 parts of polyvinyl alcohol, 0.6 part of hydroxymethyl cellulose, 3 parts of lidocaine hydrochloride Caine, 3 parts prilocaine hydrochloride, 7 parts ethanol, 15 parts propylene glycol, 10 parts menthol, 0.5 parts methylparaben, 0.3 parts phenoxyethanol, and 36 parts water.

Embodiment 2

[0070] This embodiment provides an application for skin anesthesia. According to parts by weight, the application for skin anesthesia is prepared from the following components: 12 parts of polyvinyl alcohol, 0.7 part of hydroxymethyl cellulose, 3.5 parts of lidocaine hydrochloride Caine, 3.5 parts prilocaine hydrochloride, 15 parts ethanol, 25 parts propylene glycol, 15 parts menthol, 0.7 parts methylparaben, 0.4 parts phenoxyethanol, and 67 parts water.

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Abstract

The invention provides a patch for skin anesthesia, wherein the patch for skin anesthesia comprises the components in parts by weight: 2 to 15 parts of a film forming material, 0.5 to 1 part of a thickening agent, 5 to 10 parts of anesthetic, 17 to 68 parts of a transdermal absorbent, 0.1 to 0.8 part of a bacteriostatic agent and 36 to 67 parts of water. The patch for skin anesthesia is stable indosage, easy to operate, short in onset time, long in drug efficacy time and high in anesthesia analgesia depth.

Description

technical field [0001] The invention belongs to the field of preparation and application of medicines, and in particular relates to an application for skin anesthesia and a preparation method thereof. Background technique [0002] With the development of society, people's demand for painless treatment in clinical medical practice is gradually increasing. For many dermatological medical cosmetic and therapeutic operations (laser, freezing, needle rolling, etc.), a considerable part is accompanied by a certain degree of pain, which causes patients' fear of treatment and affects their cooperation and enthusiasm for treatment. [0003] The method to solve this problem is mainly based on oral analgesics, local injection anesthetic infiltration anesthesia and smearing compound lidocaine cream at present. Oral painkillers have a first-pass effect, and the effect is slow; there will be obvious pain when injecting anesthesia, and some large-area treatments are not suitable for injec...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/70A61K47/32A61K47/38A61K31/167A61P23/02
CPCA61K9/7023A61K47/32A61K47/38A61K31/167A61P23/02A61K2300/00
Inventor 卢敏
Owner 西安博和医疗科技有限公司
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